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Search results 201 to 300 out of 323 for Mst1

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Type Details Score
Protein Domain
IPR024205 | Mst1_SARAH_domain
Type: Domain
Description: The SARAH (Sav/Rassf/Hpo) domain is found at the C terminus in three classes of eukaryotic tumour suppressors that give the domain its name. In the Sav (Salvador) and Hpo (Hippo) families, the SARAH domain mediates signal transduction from Hpo via the Sav scaffolding protein to the downstream component Wts (Warts); the phosphorylation of Wts by Hpo triggers cell cycle arrest and apoptosis by down-regulating cyclin E, Diap 1 and other targets [, ]. The SARAH domain is also involved in dimerisation, as in the human Hpo orthologue, Mst1, which homodimerises via its C-terminal SARAH domain. The SARAH domain is found associated with other domains, such as protein kinase domains, WW/rsp5/WWP domain (), C1 domain (), LIM domain (), or the Ras-associating (RA) domain ().This entry represents the C-terminal SARAH domain of Mst1. The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process [].
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Protein
Q9JI11
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
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Publication
28145433 | J:244895
 
First Author: Li C
Year: 2017
Journal: Nat Commun
Title: Dendritic cell MST1 inhibits Th17 differentiation.
Volume: 8
Pages: 14275
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Publication
37566283 | J:340944
First Author: Schirone L
Year: 2023
Journal: Cell Mol Life Sci
Title: MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation.
Volume: 80
Issue: 9
Pages: 245
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Publication
14654011 | -
First Author: Scheel H
Year: 2003
Journal: Curr Biol
Title: A novel interaction motif, SARAH, connects three classes of tumor suppressor.
Volume: 13
Issue: 23
Pages: R899-900
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Pathway
R-MMU-8852405 | Signaling by MST1
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Publication
27125670 | J:232564
First Author: Meng F
Year: 2016
Journal: Genes Dev
Title: Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation.
Volume: 30
Issue: 9
Pages: 1086-100
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Publication
30901564 | J:274046
First Author: Lee IY
Year: 2019
Journal: Mol Cell
Title: MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity.
Volume: 73
Issue: 6
Pages: 1138-1149.e6
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Publication
30478091 | J:295296
First Author: Bagherzadeh Yazdchi S
Year: 2019
Journal: J Immunol
Title: Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity.
Volume: 202
Issue: 1
Pages: 69-78
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Publication
31215035 | J:294264
First Author: Shang X
Year: 2020
Journal: J Cell Physiol
Title: Mst1 deletion reduces septic cardiomyopathy via activating Parkin-related mitophagy.
Volume: 235
Issue: 1
Pages: 317-327
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Publication
26056943 | J:228697
First Author: Fukuhara T
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis.
Volume: 463
Issue: 4
Pages: 968-74
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Publication
12384512 | J:80711
First Author: Lin Y
Year: 2002
Journal: J Biol Chem
Title: Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.
Volume: 277
Issue: 50
Pages: 47991-8001
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Publication
12223493 | J:80047
First Author: Glantschnig H
Year: 2002
Journal: J Biol Chem
Title: Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation.
Volume: 277
Issue: 45
Pages: 42987-96
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Publication
- | J:66606
   
First Author: Lee KK
Year: 2000
Journal: GenBank Submission
Title: Mus musculus STE20-like kinase MST1 mRNA, complete cds
Pages: AF271360
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Publication
26787462 | J:229973
First Author: Yasuda K
Year: 2016
Journal: FEBS Lett
Title: Enhanced cytotoxic T-cell function and inhibition of tumor progression by Mst1 deficiency.
Volume: 590
Issue: 1
Pages: 68-75
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Publication
24595170 | J:214531
First Author: Du X
Year: 2014
Journal: PLoS One
Title: Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis.
Volume: 9
Issue: 3
Pages: e90701
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Publication
19962960 | J:156774
First Author: Song H
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity.
Volume: 391
Issue: 1
Pages: 969-73
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Publication
26414765 | J:258700
First Author: Geng J
Year: 2015
Journal: Nat Immunol
Title: Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.
Volume: 16
Issue: 11
Pages: 1142-52
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Publication
27535619 | J:259552
First Author: Fan F
Year: 2016
Journal: Sci Transl Med
Title: Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
Volume: 8
Issue: 352
Pages: 352ra108
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Publication
24040101 | J:225184
First Author: Tomiyama T
Year: 2013
Journal: PLoS One
Title: Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase.
Volume: 8
Issue: 9
Pages: e73874
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Publication
20080598 | J:156541
First Author: Song H
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.
Volume: 107
Issue: 4
Pages: 1431-6
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Publication
12750396 | J:139414
First Author: Yamamoto S
Year: 2003
Journal: J Clin Invest
Title: Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.
Volume: 111
Issue: 10
Pages: 1463-74
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Publication
24464935 | J:207482
First Author: Lee SJ
Year: 2014
Journal: Glia
Title: The role of reciprocal activation of cAbl and Mst1 in the oxidative death of cultured astrocytes.
Volume: 62
Issue: 4
Pages: 639-48
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Publication
24633305 | J:210314
First Author: Ardestani A
Year: 2014
Journal: Nat Med
Title: MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.
Volume: 20
Issue: 4
Pages: 385-397
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Publication
19786569 | J:155001
First Author: Oh S
Year: 2009
Journal: Mol Cell Biol
Title: Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.
Volume: 29
Issue: 23
Pages: 6309-20
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Publication
32320827 | J:300851
First Author: Xiong Z
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice.
Volume: 1866
Issue: 8
Pages: 165806
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Publication
21516123 | J:183198
First Author: Morinaka A
Year: 2011
Journal: Oncogene
Title: Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis.
Volume: 30
Issue: 40
Pages: 4208-18
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Publication
20171103 | J:158774
First Author: Oh HJ
Year: 2010
Journal: Curr Biol
Title: MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment.
Volume: 20
Issue: 5
Pages: 416-22
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Publication
26538370 | J:271019
First Author: Hu J
Year: 2016
Journal: J Cell Mol Med
Title: Luteolin alleviates post-infarction cardiac dysfunction by up-regulating autophagy through Mst1 inhibition.
Volume: 20
Issue: 1
Pages: 147-56
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Publication
27680548 | J:293262
 
First Author: Lin J
Year: 2016
Journal: Sci Rep
Title: Mst1 inhibits CMECs autophagy and participates in the development of diabetic coronary microvascular dysfunction.
Volume: 6
Pages: 34199
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Publication
30251683 | J:270470
First Author: Hu J
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Exosomal Mst1 transfer from cardiac microvascular endothelial cells to cardiomyocytes deteriorates diabetic cardiomyopathy.
Volume: 1864
Issue: 11
Pages: 3639-3649
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Publication
30338935 | J:283105
First Author: Cheng Z
Year: 2019
Journal: J Cell Mol Med
Title: Cardiac-specific Mst1 deficiency inhibits ROS-mediated JNK signalling to alleviate Ang II-induced cardiomyocyte apoptosis.
Volume: 23
Issue: 1
Pages: 543-555
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Publication
33553168 | J:339452
 
First Author: Feng X
Year: 2020
Journal: Front Cell Dev Biol
Title: Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Volume: 8
Pages: 628842
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Publication
30387702 | J:272463
First Author: Nguyen MN
Year: 2019
Journal: Am J Physiol Heart Circ Physiol
Title: Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling.
Volume: 316
Issue: 1
Pages: H45-H60
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Publication
25600225 | J:319119
First Author: Lee GJ
Year: 2015
Journal: Basic Res Cardiol
Title: Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis.
Volume: 110
Issue: 2
Pages: 7
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Publication
30413360 | J:269836
First Author: Shi H
Year: 2018
Journal: Immunity
Title: Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.
Volume: 49
Issue: 5
Pages: 899-914.e6
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Publication
19878874 | J:153945
First Author: Zhou D
Year: 2009
Journal: Cancer Cell
Title: Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.
Volume: 16
Issue: 5
Pages: 425-38
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Interaction Experiment
Praskova M (2008)
Description: MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
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Protein
Q8CDG4
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: false
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Publication
29519817 | -
First Author: Cairns L
Year: 2018
Journal: J Biol Chem
Title: Salvador has an extended SARAH domain that mediates binding to Hippo kinase.
Volume: 293
Issue: 15
Pages: 5532-5543
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Allele
Mst1<em2Smoc> | MGI:7264951
Name: macrophage stimulating 1 (hepatocyte growth factor-like); endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
30193956 | J:270084
 
First Author: Cheng Z
Year: 2018
Journal: J Mol Cell Cardiol
Title: Mst1 knockout enhances cardiomyocyte autophagic flux to alleviate angiotensin II-induced cardiac injury independent of angiotensin II receptors.
Volume: 125
Pages: 117-128
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Protein
P26928
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Publication
22042863 | J:180226
First Author: Zhou D
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.
Volume: 108
Issue: 49
Pages: E1312-20
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Publication
32332916 | J:288198
     
First Author: Meng C
Year: 2020
Journal: Cell Death Differ
Title: Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway.
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Publication
26443704 | J:259227
First Author: Tang F
Year: 2015
Journal: Sci Signal
Title: The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.
Volume: 8
Issue: 397
Pages: ra100
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Protein Coding Gene
MGI:99614 | Mst1r
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q62190
Organism: Mus musculus/domesticus
Length: 1378  
Fragment?: false
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Interaction Experiment
Yun HJ (2011)
Description: Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.
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Strain
MGI:6429208 | C57BL/6J-Mst1<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein
Q9CW82
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
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Protein Coding Gene
MGI:1338033 | Spint1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338031 | Spint2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1196620 | Hpn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O35453
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Protein
Q9R097
Organism: Mus musculus/domesticus
Length: 507  
Fragment?: false
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Protein
Q9WU03
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
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Protein
Q9JI10
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
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Protein
A0A2I3BQE0
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: false
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Protein Coding Gene
MGI:1929004 | Stk4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17932490 | -
First Author: Cinar B
Year: 2007
Journal: EMBO J
Title: The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.
Volume: 26
Issue: 21
Pages: 4523-34
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HT Experiment
GSE61582 | Microarray of Mst1/2 deleted epithelial cells from E18.5 mouse lungs
Series Id: E-GEOD-61582
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
IPR024174 | HGF/MST1
Type: Family
Description: This entry includes hepatocyte growth factor (HGF; also called scatter factor) and HGF-like proteins (also known as macrophage stimulatory protein, MST1). Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration []. HGF is essential for placental, liver, and muscle development, whereas MST1 is not required for embryogenesis, fertility, or wound healing. Genes for HGF and its receptor, the Met tyrosine kinase, are close together on chromosome 7, so that polysomy of chromosome 7 may contribute to malignancy through overproduction of both molecules. MST1 and its receptor, the Ron tyrosine kinase, are close together on chromosome 3. HGF and MST1 are closely related to plasminogen, having similar domain architecture: signal sequence followed by a PAN (formerly apple) domain, four (rather than five) kringle domains, and a trypsin domain, which appears to lack any peptidase activity.
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Publication
20624990 | J:162562
First Author: Tolbert WD
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for agonism and antagonism of hepatocyte growth factor.
Volume: 107
Issue: 30
Pages: 13264-9
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Publication
19878866 | J:153949
First Author: Zhao B
Year: 2009
Journal: Cancer Cell
Title: Mst out and HCC in.
Volume: 16
Issue: 5
Pages: 363-4
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Publication
21151127 | J:169033
First Author: Melum E
Year: 2011
Journal: Nat Genet
Title: Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
Volume: 43
Issue: 1
Pages: 17-9
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HT Experiment
E-GEOD-73911 | The tumor suppressor Rassf1a prevents mouse liver tumorigenesis and regulates levels of the oncogenic kinase Tbk1 and of beta tubulin gene expression in the liver
Series Id: GSE73911
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
18369314 | J:134270
First Author: Lee JH
Year: 2008
Journal: EMBO J
Title: A crucial role of WW45 in developing epithelial tissues in the mouse.
Volume: 27
Issue: 8
Pages: 1231-42
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Publication
32289155 | J:288638
 
First Author: Raynor JL
Year: 2020
Journal: J Exp Med
Title: Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.
Volume: 217
Issue: 6
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Publication
30315205 | J:280042
First Author: Li W
Year: 2019
Journal: Cell Death Differ
Title: Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation.
Volume: 26
Issue: 8
Pages: 1379-1395
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Publication
30783090 | J:276795
First Author: Kim YH
Year: 2019
Journal: Nat Commun
Title: A MST1-FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis.
Volume: 10
Issue: 1
Pages: 838
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Publication
25466249 | J:315934
First Author: Manderfield LJ
Year: 2014
Journal: Cell Rep
Title: Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest.
Volume: 9
Issue: 5
Pages: 1885-1895
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Publication
18942145 | J:140710
First Author: Anguera MC
Year: 2008
Journal: Dev Dyn
Title: Characterization of two Mst1-deficient mouse models.
Volume: 237
Issue: 11
Pages: 3424-34
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Publication
30765703 | J:275408
First Author: Wang P
Year: 2019
Journal: Nat Commun
Title: Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.
Volume: 10
Issue: 1
Pages: 755
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Publication
29343826 | J:260158
First Author: Lee DH
Year: 2018
Journal: Sci Rep
Title: Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition.
Volume: 8
Issue: 1
Pages: 942
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Publication
20346707 | J:160767
First Author: Raab M
Year: 2010
Journal: Immunity
Title: T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.
Volume: 32
Issue: 4
Pages: 541-56
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Publication
31676778 | J:282218
First Author: Ardestani A
Year: 2019
Journal: Nat Commun
Title: Neratinib protects pancreatic beta cells in diabetes.
Volume: 10
Issue: 1
Pages: 5015
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Publication
23792360 | J:200005
First Author: Yao HP
Year: 2013
Journal: Nat Rev Cancer
Title: MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Volume: 13
Issue: 7
Pages: 466-81
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Publication
25692647 | J:221357
 
First Author: Bae SJ
Year: 2015
Journal: Nat Commun
Title: NEDD4 controls intestinal stem cell homeostasis by regulating the Hippo signalling pathway.
Volume: 6
Pages: 6314
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Publication
35611768 | J:334580
First Author: Liang Y
Year: 2022
Journal: Bioengineered
Title: Knockout of circRNA single stranded interacting protein 1 (circRBMS1) played a protective role in myocardial ischemia-reperfusion injury though inhibition of miR-2355-3p/Mammalian Sterile20-like kinase 1 (MST1) axis.
Volume: 13
Issue: 5
Pages: 12726-12737
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Publication
11864565 | J:79038
First Author: Khokhlatchev A
Year: 2002
Journal: Curr Biol
Title: Identification of a novel Ras-regulated proapoptotic pathway.
Volume: 12
Issue: 4
Pages: 253-65
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Publication
21730291 | J:175077
First Author: Zhou Y
Year: 2011
Journal: Mol Cell Biol
Title: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
Volume: 31
Issue: 17
Pages: 3603-15
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Publication
10980603 | J:62150
First Author: Johnston AM
Year: 2000
Journal: Oncogene
Title: SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.
Volume: 19
Issue: 37
Pages: 4290-7
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Publication
11278283 | J:69763
First Author: Lee KK
Year: 2001
Journal: J Biol Chem
Title: MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.
Volume: 276
Issue: 22
Pages: 19276-85
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Publication
20810663 | J:166871
First Author: Park J
Year: 2010
Journal: J Biol Chem
Title: Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.
Volume: 285
Issue: 45
Pages: 35029-38
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Publication
20551432 | J:185408
First Author: Cornils H
Year: 2010
Journal: Sci Signal
Title: Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.
Volume: 3
Issue: 126
Pages: ra47
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Publication
32600317 | J:319394
First Author: Ishihara S
Year: 2020
Journal: BMC Biol
Title: Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.
Volume: 18
Issue: 1
Pages: 75
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Publication
23454691 | J:255620
First Author: Gao T
Year: 2013
Journal: Gastroenterology
Title: Hippo signaling regulates differentiation and maintenance in the exocrine pancreas.
Volume: 144
Issue: 7
Pages: 1543-53, 1553.e1
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Publication
25480985 | J:318015
First Author: Lange AW
Year: 2015
Journal: J Mol Cell Biol
Title: Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.
Volume: 7
Issue: 1
Pages: 35-47
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Publication
17379520 | J:121661
First Author: Guo C
Year: 2007
Journal: Curr Biol
Title: RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.
Volume: 17
Issue: 8
Pages: 700-5
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Publication
26980762 | J:231761
First Author: Zhang X
Year: 2016
Journal: Cancer Res
Title: Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1.
Volume: 76
Issue: 9
Pages: 2824-35
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Publication
20890045 | J:165327
First Author: Del Re DP
Year: 2010
Journal: J Clin Invest
Title: Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice.
Volume: 120
Issue: 10
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