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Search results 1 to 100 out of 946 for Alk

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
238 | ALK
Type: gene
Organism: human
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Gene
563509 | alk
Type: gene
Organism: zebrafish
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Gene
704823 | ALK
Type: gene
Organism: macaque, rhesus
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Gene
100495071 | alk
Type: gene
Organism: frog, western clawed
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Gene
483021 | ALK
Type: gene
Organism: dog, domestic
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Gene
266802 | Alk
Type: gene
Organism: rat
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Gene
459127 | ALK
Type: gene
Organism: chimpanzee
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Gene
536642 | ALK
Type: gene
Organism: cattle
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Gene
421297 | ALK
Type: gene
Organism: chicken
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Protein Domain
IPR026830 | ALK
Type: Family
Description: ALK tyrosine kinase receptor (also known as anaplastic lymphoma kinase, ALK) is a neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system [].ALK transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 [, , ]. ALK acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation [, ]. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction [].
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Protein Coding Gene
MGI:103305 | Alk
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15226403 | -
First Author: Motegi A
Year: 2004
Journal: J Cell Sci
Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Volume: 117
Issue: Pt 15
Pages: 3319-29
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Publication
17274988 | -
First Author: Degoutin J
Year: 2007
Journal: FEBS Lett
Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.
Volume: 581
Issue: 4
Pages: 727-34
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Protein
P97793
Organism: Mus musculus/domesticus
Length: 1621  
Fragment?: false
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Publication
32442405 | J:291736
First Author: Orthofer M
Year: 2020
Journal: Cell
Title: Identification of ALK in Thinness.
Volume: 181
Issue: 6
Pages: 1246-1262.e22
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Publication
11121404 | -
First Author: Souttou B
Year: 2001
Journal: J Biol Chem
Title: Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.
Volume: 276
Issue: 12
Pages: 9526-31
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Publication
12107166 | -
First Author: Bowden ET
Year: 2002
Journal: J Biol Chem
Title: Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.
Volume: 277
Issue: 39
Pages: 35862-8
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Publication
12122009 | -
First Author: Stoica GE
Year: 2002
Journal: J Biol Chem
Title: Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.
Volume: 277
Issue: 39
Pages: 35990-8
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Publication
11278720 | -
First Author: Stoica GE
Year: 2001
Journal: J Biol Chem
Title: Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.
Volume: 276
Issue: 20
Pages: 16772-9
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Publication
16458083 | J:109486
First Author: Vernersson E
Year: 2006
Journal: Gene Expr Patterns
Title: Characterization of the expression of the ALK receptor tyrosine kinase in mice.
Volume: 6
Issue: 5
Pages: 448-61
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Publication
19200234 | J:146467
First Author: Degoutin J
Year: 2009
Journal: Eur J Neurosci
Title: ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction.
Volume: 29
Issue: 2
Pages: 275-86
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Publication
37291945 | J:338243
First Author: Christova T
Year: 2023
Journal: EMBO Rep
Title: LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
Volume: 24
Issue: 7
Pages: e56937
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Protein
Q80UG6
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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Protein
J3QPP8
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Publication
24811761 | J:226655
First Author: Lopez-Delisle L
Year: 2014
Journal: Oncotarget
Title: Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.
Volume: 5
Issue: 9
Pages: 2703-13
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Publication
9053841 | J:38743
First Author: Iwahara T
Year: 1997
Journal: Oncogene
Title: Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.
Volume: 14
Issue: 4
Pages: 439-49
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Publication
17487225 | J:226526
First Author: Bilsland JG
Year: 2008
Journal: Neuropsychopharmacology
Title: Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.
Volume: 33
Issue: 3
Pages: 685-700
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Gene
285016 | ALKAL2
Type: gene
Organism: human
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Gene
389658 | ALKAL1
Type: gene
Organism: human
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Publication
25955180 | J:226955
First Author: Witek B
Year: 2015
Journal: PLoS One
Title: Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism.
Volume: 10
Issue: 5
Pages: e0123542
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Publication
16189272 | J:126614
First Author: Piva R
Year: 2006
Journal: Blood
Title: Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas.
Volume: 107
Issue: 2
Pages: 689-97
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Publication
31218818 | J:294092
First Author: Ono S
Year: 2019
Journal: Genesis
Title: Generation of conditional ALK F1174L mutant mouse models for the study of neuroblastoma pathogenesis.
Volume: 57
Issue: 10
Pages: e23323
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Publication
29321660 | J:261033
First Author: Lopez-Delisle L
Year: 2018
Journal: Oncogene
Title: Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.
Volume: 37
Issue: 11
Pages: 1417-1429
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Publication
24811913 | J:228124
First Author: Cazes A
Year: 2014
Journal: Oncotarget
Title: Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma.
Volume: 5
Issue: 9
Pages: 2688-702
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GXD Expression
GXD Expression
     
Probe: MGI:6167290
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6189767
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Alk
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6167290
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189767
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Alk
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6167290
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189767
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Alk
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6167290
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189767
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Alk
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6167290
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189767
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Alk
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6167290
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189767
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Alk
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6167290
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189767
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Alk
Detected: true
Specimen Num: 7
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Publication
30497772 | J:281259
First Author: Tang C
Year: 2019
Journal: Neuron
Title: Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN.
Volume: 101
Issue: 1
Pages: 32-44.e6
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Publication
28455243 | J:242580
 
First Author: Lu J
Year: 2017
Journal: Cancer Lett
Title: The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.
Volume: 400
Pages: 61-68
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Publication
22079349 | J:226591
First Author: Weiss JB
Year: 2012
Journal: Pharmacol Biochem Behav
Title: Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.
Volume: 100
Issue: 3
Pages: 566-74
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Publication
32312912 | J:308467
 
First Author: Gualandi M
Year: 2020
Journal: Life Sci Alliance
Title: Oncogenic ALK F1174L drives tumorigenesis in cutaneous squamous cell carcinoma.
Volume: 3
Issue: 6
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Publication
21799923 | J:227538
First Author: Lasek AW
Year: 2011
Journal: PLoS One
Title: An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.
Volume: 6
Issue: 7
Pages: e22636
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Protein Coding Gene
MGI:3645495 | Alkal1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3697448 | Alkal2
Type: protein_coding_gene
Organism: mouse, laboratory
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Author
Derrick-Roberts ALK
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Publication
24667968 | J:215052
First Author: Jamin Y
Year: 2014
Journal: PLoS One
Title: Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma.
Volume: 9
Issue: 3
Pages: e92886
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Publication
28629962 | J:249796
 
First Author: Weiss JB
Year: 2017
Journal: Behav Brain Res
Title: Pharmacological inhibition of Anaplastic Lymphoma Kinase rescues spatial memory impairments in Neurofibromatosis 1 mutant mice.
Volume: 332
Pages: 337-342
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Publication
26630010 | -
First Author: Reshetnyak AV
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
Volume: 112
Issue: 52
Pages: 15862-7
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Publication
25173427 | J:227752
First Author: Lovly CM
Year: 2014
Journal: Nat Med
Title: Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.
Volume: 20
Issue: 9
Pages: 1027-34
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Publication
18923524 | J:338891
First Author: Chen Y
Year: 2008
Journal: Nature
Title: Oncogenic mutations of ALK kinase in neuroblastoma.
Volume: 455
Issue: 7215
Pages: 971-4
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Publication
28057529 | J:249635
 
First Author: Weiss JB
Year: 2017
Journal: Behav Brain Res
Title: Genetic inhibition of Anaplastic Lymphoma Kinase rescues cognitive impairments in Neurofibromatosis 1 mutant mice.
Volume: 321
Pages: 148-156
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Publication
34646012 | -
First Author: De Munck S
Year: 2021
Journal: Nature
Title: Structural basis of cytokine-mediated activation of ALK family receptors.
Volume: 600
Issue: 7887
Pages: 143-147
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GXD Expression
GXD Expression
     
Probe: MGI:7491753
Assay Type: RT-PCR
Annotation Date: 2023-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1768125
Stage: TS25
Assay Id: MGI:7491758
Age: embryonic day 17.5
Specimen Label: Alk phos
Detected: true
Specimen Num: 1
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Gene
119873261 | LOC119873261
Type: gene
Organism: dog, domestic
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Gene
124416957 | LOC124416957
Type: gene
Organism: chicken
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Gene
121394155 | LOC121394155
Type: gene
Organism: frog, African clawed
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Publication
38039964 | J:351833
First Author: Bergaggio E
Year: 2023
Journal: Cancer Cell
Title: ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells.
Volume: 41
Issue: 12
Pages: 2100-2116.e10
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Publication
22789543 | J:191012
First Author: Berry T
Year: 2012
Journal: Cancer Cell
Title: The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma.
Volume: 22
Issue: 1
Pages: 117-30
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Publication
20855625 | J:165415
First Author: Chun MG
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis.
Volume: 107
Issue: 40
Pages: 17268-73
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Publication
25456124 | J:218755
First Author: Blasco RB
Year: 2014
Journal: Cell Rep
Title: Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology.
Volume: 9
Issue: 4
Pages: 1219-27
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Publication
9174053 | J:40563
First Author: Morris SW
Year: 1997
Journal: Oncogene
Title: ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
Volume: 14
Issue: 18
Pages: 2175-88
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Publication
12748172 | J:84931
First Author: Ouyang T
Year: 2003
Journal: J Biol Chem
Title: Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
Volume: 278
Issue: 32
Pages: 30028-36
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Publication
18469826 | J:136968
First Author: Chiarle R
Year: 2008
Journal: Nat Med
Title: The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.
Volume: 14
Issue: 6
Pages: 676-80
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Publication
26829053 | J:230720
First Author: Ueda T
Year: 2016
Journal: Oncogene
Title: ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.
Volume: 35
Issue: 34
Pages: 4447-58
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Publication
26206265 | J:334956
First Author: He D
Year: 2015
Journal: J Neurochem
Title: Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain.
Volume: 135
Issue: 3
Pages: 508-21
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Publication
29555900 | J:265720
First Author: Gonzalez Malagon SG
Year: 2018
Journal: Nat Commun
Title: Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus.
Volume: 9
Issue: 1
Pages: 1126
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Publication
25193384 | J:216687
First Author: Martinengo C
Year: 2014
Journal: Cancer Res
Title: ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis.
Volume: 74
Issue: 21
Pages: 6094-106
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Publication
12555065 | J:81542
First Author: Lange K
Year: 2003
Journal: Oncogene
Title: Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.
Volume: 22
Issue: 4
Pages: 517-27
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Publication
21945349 | J:178546
First Author: Azarova AM
Year: 2011
Journal: Semin Cancer Biol
Title: Emerging importance of ALK in neuroblastoma.
Volume: 21
Issue: 4
Pages: 267-75
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Interaction Term
MI:0366 | alkaline phosphatase tag
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Interaction Term
MI:1323 | tag visualisation by alkaline phosphatase activity
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Protein Coding Gene
MGP_CAROLIEiJ_G0021865 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024015 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023942 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023974 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023738 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_103305 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024420 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023219 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023842 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023808 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0023924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024464 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022965 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023286 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020852 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022776 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:5750208
Assay Type: Western blot
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:5750209
Age: postnatal adult
Image: S2
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5750208
Assay Type: Western blot
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:5750209
Age: postnatal adult
Image: S2
Specimen Label: HT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5750208
Assay Type: Western blot
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:5750209
Age: postnatal adult
Image: S2
Specimen Label: HM
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7543996
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7544028
Age: embryonic day 15.5
Image: EV1
Specimen Label: E15.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7543996
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7544028
Age: postnatal day 0
Image: EV1
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7543996
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7544028
Age: postnatal day 2
Image: EV1
Specimen Label: P2
Detected: true
Specimen Num: 3
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•
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