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Search results 101 to 200 out of 260 for Rad18

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Type Details Score
Publication
15383616 | J:92954
First Author: van der Laan R
Year: 2004
Journal: J Cell Sci
Title: Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.
Volume: 117
Issue: Pt 21
Pages: 5023-33
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Publication
15657431 | J:95995
First Author: Baarends WM
Year: 2005
Journal: Mol Cell Biol
Title: Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.
Volume: 25
Issue: 3
Pages: 1041-53
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Publication
36546838 | J:336101
First Author: Dickinson K
Year: 2023
Journal: Am J Physiol Renal Physiol
Title: WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.
Volume: 324
Issue: 3
Pages: F245-F255
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Publication
25340873 | J:232539
First Author: DiTommaso T
Year: 2014
Journal: PLoS Genet
Title: Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
Volume: 10
Issue: 10
Pages: e1004705
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Publication
19213844 | J:158060
First Author: Chesnokova V
Year: 2009
Journal: Endocrinology
Title: Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence.
Volume: 150
Issue: 6
Pages: 2603-10
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Publication
21425081 | J:170314
First Author: Albino D
Year: 2011
Journal: Int J Dev Biol
Title: Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration.
Volume: 55
Issue: 1
Pages: 65-72
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Publication
24652767 | J:213427
First Author: Adissu HA
Year: 2014
Journal: Dis Model Mech
Title: Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Volume: 7
Issue: 5
Pages: 515-24
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Publication
24721909 | J:209956
 
First Author: Liakath-Ali K
Year: 2014
Journal: Nat Commun
Title: Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.
Volume: 5
Pages: 3540
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase RAD18
Type: chain
End: 509
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Publication
19396164 | J:325269
First Author: Huang J
Year: 2009
Journal: Nat Cell Biol
Title: RAD18 transmits DNA damage signalling to elicit homologous recombination repair.
Volume: 11
Issue: 5
Pages: 592-603
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Publication
38528023 | J:346582
First Author: Kalweit K
Year: 2024
Journal: Sci Rep
Title: Role of Rad18 in B cell activation and lymphomagenesis.
Volume: 14
Issue: 1
Pages: 7066
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Allele
Gt(ROSA)26Sor<tm1(RNU6-RNAi:Rad18)Wbaa> | MGI:5295281
 
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Willy M Baarends
Allele Type: Targeted
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Allele
Rad18<+> | MGI:2439575
   
Name: RAD18 E3 ubiquitin protein ligase; wild type
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Publication
16980296 | -
First Author: Nakajima S
Year: 2006
Journal: J Biol Chem
Title: Replication-dependent and -independent responses of RAD18 to DNA damage in human cells.
Volume: 281
Issue: 45
Pages: 34687-95
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Allele
Rad18<tm1(KOMP)Vlcg> | MGI:5051487
Name: RAD18 E3 ubiquitin protein ligase; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Rad18<tm1Stat> | MGI:3835812
Name: RAD18 E3 ubiquitin protein ligase; targeted mutation 1, Satoshi Tateishi
Allele Type: Targeted
Attribute String: Null/knockout
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Interaction Experiment
Yanagihara H (2011)
Description: NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol -dependent translesion DNA synthesis.
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Interaction Experiment
Notenboom V (2007)
Description: Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification.
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Interaction Experiment
Tateishi S (2003)
Description: Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells.
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Allele
Rad18<em4Gpt> | MGI:7305127
Name: RAD18 E3 ubiquitin protein ligase; endonuclease-mediated mutation 4, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:3835929 | B6.Cg-Rad18<tm1Stat>
Attribute String: congenic, targeted mutation
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Allele
Rad18<Gt(F060F04)Wrst> | MGI:4123416
 
Name: RAD18 E3 ubiquitin protein ligase; gene trap F060F04, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Rad18<em1Gpt> | MGI:7305126
Name: RAD18 E3 ubiquitin protein ligase; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Rad18<Gt(E211D09)Wrst> | MGI:3918729
 
Name: RAD18 E3 ubiquitin protein ligase; gene trap E211D09, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Rad18<tm1a(EUCOMM)Wtsi> | MGI:4433190
Name: RAD18 E3 ubiquitin protein ligase; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Rad18<Gt(IST11557C4)Tigm> | MGI:5148002
 
Name: RAD18 E3 ubiquitin protein ligase; gene trap IST11557C4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Genotype
Genotype
Symbol: Rad18/Rad18
Background: B6.Cg-Rad18
Zygosity: hm
Has Mutant Allele: true
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Publication
2970061 | -
First Author: Jones JS
Year: 1988
Journal: Nucleic Acids Res
Title: The Saccharomyces cerevisiae RAD18 gene encodes a protein that contains potential zinc finger domains for nucleic acid binding and a putative nucleotide binding sequence.
Volume: 16
Issue: 14B
Pages: 7119-31
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Publication
10747036 | -
First Author: Fousteri MI
Year: 2000
Journal: EMBO J
Title: A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein.
Volume: 19
Issue: 7
Pages: 1691-702
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Publication
21884979 | -
First Author: Yanagihara H
Year: 2011
Journal: Mol Cell
Title: NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Volume: 43
Issue: 5
Pages: 788-97
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Publication
25162118 | -
First Author: Rizzo AA
Year: 2014
Journal: Biochemistry
Title: NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response.
Volume: 53
Issue: 37
Pages: 5895-906
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Strain
MGI:5556487 | B6Brd;B6N-Tyr<c-Brd> Rad18<tm1a(EUCOMM)Wtsi>/WtsiCnbc
Attribute String: mutant strain, targeted mutation, spontaneous mutation
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Strain
MGI:5781346 | B6JTyr;B6N-Rad18<tm1a(EUCOMM)Wtsi>/Wtsi
Attribute String: mutant stock, targeted mutation
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Genotype
Genotype
Symbol: Rad18/Rad18
Background: B6JTyr;B6N-Rad18/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad18/Rad18
Background: involves: C57BL/6 * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad18/Rad18
Background: B6Brd;B6Dnk;B6N-Tyr Rad18/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR004580 | Rad18_fungi
Type: Family
Description: During DNA replication, lesion bypass is an important cellular response to unrepaired damage in the genome. In the yeastSaccharomyces cerevisiae (Baker's yeast), Rad6 and Rad18 are required for both the error-free and error-prone lesion bypass mechanisms. The Rad18 gene encodes a RING-finger protein with single-stranded DNA binding activity that interacts with theubiquitin-conjugating enzyme Rad6. This entry represents the Rad8 from fungi.
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Protein Domain
IPR040539 | Znf-WRNIP1_ubi
Type: Domain
Description: This domain is found in the Werner helicase-interacting protein 1 present in Homo sapiens. The domain is a zinc finger responsible and has a zinc-coordinating B-B-A fold. WRNIP1 UBZ binds ubiquitin in a similar manner to Rad18 UBZ [].
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Publication
24794496 | J:214661
First Author: Lachaud C
Year: 2014
Journal: J Cell Sci
Title: Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia.
Volume: 127
Issue: Pt 13
Pages: 2811-7
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Protein
S4R284
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
F6R0R3
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q9CRV6
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
F7A9G8
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: true
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Protein Domain
IPR006642 | Rad18_UBZ4
Type: Domain
Description: The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating β-β-α fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families [, ]. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1) [, , ], type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex [, ], type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta [, , ], and type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase-interacting protein 1 (WRNIP1), and Rad18 [, , ]. The UBZ domain consists of two short antiparallel β-strands followed by one α-helix. The α-helix packs against the β-strands with a zinc ion sandwiched between the α-helix and the β-strands. The zinc ion is coordinated by two cysteines located on the fingertip formed by the β-strands and two histidines [, ]or one histidine and one cysteine []on the α-helix [].This entry represents type 4 UBZ found in RAD18. The domain is a potential zinc finger for nucleic acid binding and a putative nucleotide binding sequence []. Human RAD18 accumulates very rapidly and remains for a long period of time at sites of different types of DNA damage, and is required of DNA. RAD18 appears to respond to DNA damage in two distinct ways: replication-dependent and replication-independent. The RAD18-type zinc finger located in the middle of RAD18 is responsible for the replication-independent accumulation of RAD18 following DNA damage, while a second zinc finger, SAP-type, is responsible for replication-dependent accumulation [].
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Protein
Q3UH46
Organism: Mus musculus/domesticus
Length: 687  
Fragment?: false
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Publication
12459258 | -
First Author: Nikali K
Year: 2002
Journal: Gene
Title: cDNA cloning, expression profile and genomic structure of a novel human transcript on chromosome 10q24, and its analyses as a candidate gene for infantile onset spinocerebellar ataxia.
Volume: 299
Issue: 1-2
Pages: 111-5
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Protein Domain
IPR026161 | FAM178
Type: Family
Description: This entry represents the FAM178 family, whose members are metazoan proteins and include FAM178A and FAM178B. The human FAM178A protein has been shown to be widely expressed []and is phosphorylated upon DNA damage, probably by ATM (ataxia telangiectasia mutated) or ATR (ATM and Rad3-related) [, ].FAM178A, also known as SLF2 (SMC5-SMC6 complex localization factor 2), forms a complex with RAD18 and SLF1, and together they define a pathway that suppresses genome instability by recruiting the SMC5/6 cohesion complex to DNA lesions [, ].
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Protein
Q9JIC3
Organism: Mus musculus/domesticus
Length: 1026  
Fragment?: false
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Protein
S4R1N2
Organism: Mus musculus/domesticus
Length: 1029  
Fragment?: false
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Publication
22036607 | J:224731
First Author: Liu T
Year: 2012
Journal: DNA Repair (Amst)
Title: RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage.
Volume: 11
Issue: 2
Pages: 131-8
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Publication
27377895 | J:240783
 
First Author: Gao Y
Year: 2016
Journal: Nat Commun
Title: A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.
Volume: 7
Pages: 12105
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Publication
38175749 | J:344367
First Author: Marple T
Year: 2024
Journal: Cell Rep
Title: TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis.
Volume: 43
Issue: 1
Pages: 113637
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Protein
Q5Q9G9
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: false
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Publication
27062441 | J:248713
First Author: Suzuki N
Year: 2016
Journal: FEBS J
Title: A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
Volume: 283
Issue: 11
Pages: 2004-17
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Publication
25931565 | -
First Author: Räschle M
Year: 2015
Journal: Science
Title: DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.
Volume: 348
Issue: 6234
Pages: 1253671
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Publication
11408570 | J:162301
First Author: Taylor EM
Year: 2001
Journal: Mol Biol Cell
Title: Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.
Volume: 12
Issue: 6
Pages: 1583-94
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Publication
25787082 | J:250419
First Author: Meng X
Year: 2015
Journal: J Biol Chem
Title: Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs.
Volume: 290
Issue: 19
Pages: 11853-64
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Publication
26187992 | J:233042
First Author: Yang Y
Year: 2015
Journal: Nucleic Acids Res
Title: FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress.
Volume: 43
Issue: 17
Pages: 8325-39
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Publication
17304240 | -
First Author: Bomar MG
Year: 2007
Journal: EMBO Rep
Title: Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta.
Volume: 8
Issue: 3
Pages: 247-51
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Title: Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.
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Journal: DNA Repair (Amst)
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