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Search results 301 to 329 out of 329 for Ext2

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Type Details Score
Protein
P97464
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Protein
Q3V1P4
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
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Publication
25644707 | J:221064
First Author: de Andrea CE
Year: 2015
Journal: J Pathol
Title: Cell cycle deregulation and mosaic loss of Ext1 drive peripheral chondrosarcomagenesis in the mouse and reveal an intrinsic cilia deficiency.
Volume: 236
Issue: 2
Pages: 210-8
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Publication
25568062 | J:220029
First Author: Mooij HL
Year: 2015
Journal: J Lipid Res
Title: Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans.
Volume: 56
Issue: 3
Pages: 665-73
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Publication
23192691 | J:237157
First Author: Jones KB
Year: 2013
Journal: J Orthop Res
Title: Toward an understanding of the short bone phenotype associated with multiple osteochondromas.
Volume: 31
Issue: 4
Pages: 651-7
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Publication
15161920 | J:91757
First Author: Yamada S
Year: 2004
Journal: J Biol Chem
Title: Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.
Volume: 279
Issue: 31
Pages: 32134-41
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Publication
27387504 | J:236935
First Author: Deligny A
Year: 2016
Journal: J Biol Chem
Title: NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length.
Volume: 291
Issue: 36
Pages: 18600-18607
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Publication
8981950 | J:48119
First Author: Hecht JT
Year: 1997
Journal: Am J Hum Genet
Title: Hereditary multiple exostoses (EXT): mutational studies of familial EXT1 cases and EXT-associated malignancies.
Volume: 60
Issue: 1
Pages: 80-6
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Publication
24370655 | J:209462
 
First Author: Jochmann K
Year: 2014
Journal: Matrix Biol
Title: Heparan sulfate as a regulator of endochondral ossification and osteochondroma development.
Volume: 34
Pages: 55-63
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Publication
24726293 | J:215406
 
First Author: Jochmann K
Year: 2014
Journal: Matrix Biol
Title: Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma development.
Volume: 35
Pages: 239-47
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Publication
9473480 | -
First Author: Saito T
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family.
Volume: 243
Issue: 1
Pages: 61-6
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Publication
14659703 | -
First Author: Zhong R
Year: 2003
Journal: Trends Plant Sci
Title: Unraveling the functions of glycosyltransferase family 47 in plants.
Volume: 8
Issue: 12
Pages: 565-8
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Protein Domain
IPR040911 | Exostosin_GT47
Type: Domain
Description: There are five identified human EXT family proteins (EXT1, EXT2, EXTL1, EXTL2 and EXTL3), which are members of the hereditary multiple exostoses family of tumor suppressors []. They are glycosyltransferases required for the biosynthesis of heparan sulfate. Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterised by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses []. Mutations in two homologous genes, EXT1 and EXT2, are responsible for the EXT syndrome. The human and mouse EXT genes have at least two homologues in the invertebrate Caenorhabditis elegans, indicating that they do not function exclusively as regulators of bone growth. EXT1 and EXT2 have both been shown to encode glycosyltransferases involved in the chain elongation step of heparan sulphate biosynthesis [].In addition to a b-glucuronyltransferase domain, exostosins contain anadditional alpha 1,4-N-acetylglucosaminyltransferase domain that belongs to family GT64 [, ]. Activities of both exostosin GT domains are required for synthesizing the backbone of glycosaminoglycan, heparan sulfate. In plants, many genes have been shown to encode proteins with significant sequence similarity to the exostosinb-glucuronyltransferase domain and therefore are grouped into family GT47 []. This entry represents the GT47 domain of exostosins.
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Publication
32818603 | J:333143
First Author: Kawashima K
Year: 2020
Journal: Osteoarthritis Cartilage
Title: Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.
Volume: 28
Issue: 11
Pages: 1459-1470
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Publication
20377530 | J:163045
First Author: Okada M
Year: 2010
Journal: Biochem J
Title: Biosynthesis of heparan sulfate in EXT1-deficient cells.
Volume: 428
Issue: 3
Pages: 463-71
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Protein
Q9WVL6
Organism: Mus musculus/domesticus
Length: 918  
Fragment?: false
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Protein
Q9JKV7
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: false
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Protein
Q0VAW4
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: false
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Protein
Q6P1H4
Organism: Mus musculus/domesticus
Length: 919  
Fragment?: false
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Protein
Q5DU26
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: true
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Protein
Q3UUW7
Organism: Mus musculus/domesticus
Length: 832  
Fragment?: true
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Protein
Q3T9C7
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: false
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Protein
Q3TSP4
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: true
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Protein
Q9ES89
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
K0J1C6
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
Q3TXF7
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q8C197
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q8C089
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: true
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Protein
Q3TSR0
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
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