AKIP1 regulates the effect of the cAMP-dependent protein kinase (PKAc) signalling pathway on the NF-kB activation cascade [, ]. AKIP1 binds PKA []and co-localises with the NF-kB subunit p65 []. In humans, there are three splice variants, whereas only the full-length protein is present in rodents []. AKIP1 seems to act as a modulator of PKA in NF-kappaB signalling; different splice variants have been shown to repress []or enhance NF-kB transcription [].
