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Search results 1 to 3 out of 3 for Chd1

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Domain
Description: CDH1 is an ATP-dependent chromatin-remodelling factor and plays an important role in regulating nucleosome assembly and mobilization. CHD1 consists of double chromodomain, SNF2-related ATPase domain, and a C-terminal DNA-binding domain. The DNA-binding domain contains SANT (Swi3, Ada2, N-CoR, TFIIIB) and SLIDE (SANT-like ISWI) domains in its C-terminal region []. SANT domains are structurally related to Myb-like domains are common motifs found in chromatin interacting proteins. Deletion of individual SANT or SLIDE domains in CDH1 does not significantly affect nucleosome binding, but combined deletion of both domains severely compromise binding, suggesting that the SANT-SLIDE motif recognizes DNA/nucleosomes as a single cooperative unit. SANT sequences of Chd1 proteins are the most distantly relation group of sequences relation to other SANT/Myb sequences, and are more diverse than other SANT proteins []. The SANT and SLIDE regions are well conserved in both Chd1 and ISWI (imitation switch) remodelling enzymes []. This domain comprises the SANT region and the helical linker region 1 (HL1).
Protein Domain
Type: Domain
Description: This domain can be found in chromodomain helicase DNA-binding protein 1 (Chd1) present in Saccharomyces cerevisiae. Cdh1 proteins have been associated with the efficient assembly and spacing of nucleosomes []. Chd1 consists of a double chromodomain, an Snf2-related ATPase domain and a C-terminal DNA binding domain [, ].This domain comprises the first four helices of the Chd1 DNA binding domain, which can be divided into regions SANT, HL1 and the β-linker. The HL1 region comprises of some 40 residues specific to budding yeast that are unlikely to form such a prominent feature or perform a conserved function in other species. Basic residues on the alpha-1 helix are thought to be important for DNA interaction [].This domain is also found in the Hrp3 protein, another member of the Cdh1 family in Schizosaccharomyces pombe. Like Cdh1, Hrp3 also comprises two chromo-domains, SNF2-like ATPase/7 helicase domains, and a C-terminal DNA binding domain [].
Protein Domain
Type: Domain
Description: Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localisation. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region []. This entry represents a conserved domain found in TMEM131 and TMEM131L. This domain is C-terminal to the CHD1 domain.