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Search results 3601 to 3700 out of 4310 for Apc

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Type Details Score
Publication
10668484 | J:60808
 
First Author: Williams C
Year: 1999
Journal: Ann N Y Acad Sci
Title: The role of COX-2 in intestinal cancer.
Volume: 889
Pages: 72-83
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Publication
2153166 | J:27031
First Author: Mizuochi T
Year: 1990
Journal: J Immunol
Title: A selective signaling defect in helper T cells induced by antigen-presenting cells from mice with murine acquired immunodeficiency syndrome.
Volume: 144
Issue: 1
Pages: 313-6
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Publication
2978828 | J:26258
First Author: Saito N
Year: 1985
Journal: Exp Clin Immunogenet
Title: Low responsiveness to MLM bacilli associated with an impaired macrophage function in CBA/J mice.
Volume: 2
Issue: 1
Pages: 24-35
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Publication
7539756 | J:25774
First Author: Haruna H
Year: 1995
Journal: Eur J Immunol
Title: Abnormalities of B cells and dendritic cells in SAMP1 mice.
Volume: 25
Issue: 5
Pages: 1319-25
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Publication
7561122 | J:29173
First Author: Shimizu J
Year: 1995
Journal: J Immunol
Title: Relationship between beta cell injury and antigen presentation in NOD mice.
Volume: 155
Issue: 8
Pages: 4095-9
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Publication
8757954 | J:38179
First Author: Kristensen NM
Year: 1996
Journal: Int Immunol
Title: Induction of T cell responses to the invariant chain derived peptide CLIP in mice immunized with the group 1 allergen of house dust mite.
Volume: 8
Issue: 7
Pages: 1091-8
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Publication
9110401 | J:40099
First Author: Prolla TA
Year: 1996
Journal: Semin Cancer Biol
Title: DNA mismatch repair deficient mice in cancer research.
Volume: 7
Issue: 5
Pages: 241-7
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Publication
9551900 | J:45171
First Author: Armstrong TD
Year: 1998
Journal: J Immunol
Title: MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes.
Volume: 160
Issue: 2
Pages: 661-6
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Publication
12060718 | J:77346
First Author: Haigis KM
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Intestinal adenomas can develop with a stable karyotype and stable microsatellites.
Volume: 99
Issue: 13
Pages: 8927-31
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Publication
12218092 | J:78961
First Author: Cannons JL
Year: 2002
Journal: J Immunol
Title: Cutting edge: profound defect in T cell responses in TNF receptor-associated factor 2 dominant negative mice.
Volume: 169
Issue: 6
Pages: 2828-31
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Publication
12542973 | J:81584
First Author: Dashwood RH
Year: 2003
Journal: J Biochem Mol Biol
Title: Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis.
Volume: 36
Issue: 1
Pages: 35-42
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Publication
15356109 | J:92755
First Author: Boisvert J
Year: 2004
Journal: J Immunol
Title: Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites.
Volume: 173
Issue: 6
Pages: 3647-52
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Publication
15990122 | J:99984
First Author: Hursting SD
Year: 2005
Journal: Mutat Res
Title: The utility of genetically altered mouse models for nutrition and cancer chemoprevention research.
Volume: 576
Issue: 1-2
Pages: 80-92
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Publication
16148102 | J:116722
First Author: Sköld M
Year: 2005
Journal: J Immunol
Title: Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation.
Volume: 175
Issue: 6
Pages: 3584-93
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Publication
10748232 | J:120543
First Author: Hwang I
Year: 2000
Journal: J Exp Med
Title: T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells.
Volume: 191
Issue: 7
Pages: 1137-48
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Publication
17696481 | J:128592
First Author: Bose M
Year: 2007
Journal: J Agric Food Chem
Title: Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil.
Volume: 55
Issue: 19
Pages: 7695-700
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Publication
16849480 | J:137999
First Author: Tskvitaria-Fuller I
Year: 2006
Journal: J Immunol
Title: Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization.
Volume: 177
Issue: 3
Pages: 1708-20
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Publication
18460581 | J:139784
First Author: Hendriksen J
Year: 2008
Journal: J Cell Sci
Title: Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway.
Volume: 121
Issue: 11
Pages: 1793-802
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Publication
19017931 | J:142210
First Author: Anderson AC
Year: 2008
Journal: J Immunol
Title: Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.
Volume: 181
Issue: 11
Pages: 7449-52
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Publication
19263594 | J:147091
First Author: Taketo MM
Year: 2009
Journal: Gastroenterology
Title: Mouse models of colon cancer.
Volume: 136
Issue: 3
Pages: 780-98
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Publication
19047054 | J:147606
First Author: Harmey D
Year: 2009
Journal: J Biol Chem
Title: The anaphase promoting complex induces substrate degradation during neuronal differentiation.
Volume: 284
Issue: 7
Pages: 4317-23
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Publication
19965510 | J:155048
First Author: Homer H
Year: 2009
Journal: Science
Title: A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression.
Volume: 326
Issue: 5955
Pages: 991-4
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Publication
26426881 | J:233773
First Author: Pereira CS
Year: 2016
Journal: Eur J Immunol
Title: Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner.
Volume: 46
Issue: 1
Pages: 147-53
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Publication
29434238 | J:314188
First Author: Malo CS
Year: 2018
Journal: Nat Commun
Title: Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses.
Volume: 9
Issue: 1
Pages: 633
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Publication
31427428 | J:287822
 
First Author: Zhou C
Year: 2019
Journal: J Cell Sci
Title: First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation.
Volume: 132
Issue: 18
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Publication
31431458 | J:281714
First Author: Flanagan DJ
Year: 2019
Journal: Cancer Res
Title: Wnt Signaling in Cancer: Not a Binary ON:OFF Switch.
Volume: 79
Issue: 23
Pages: 5901-5906
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Publication
33397922 | J:300957
First Author: Pickering KA
Year: 2021
Journal: Nat Commun
Title: A RAC-GEF network critical for early intestinal tumourigenesis.
Volume: 12
Issue: 1
Pages: 56
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Publication
33468643 | J:301528
 
First Author: Hellmeier J
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens.
Volume: 118
Issue: 4
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Publication
29805107 | J:305912
First Author: Giroux V
Year: 2018
Journal: Stem Cell Reports
Title: Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating.
Volume: 10
Issue: 6
Pages: 1947-1958
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Publication
32451499 | J:306049
First Author: Allen BM
Year: 2020
Journal: Nat Med
Title: Systemic dysfunction and plasticity of the immune macroenvironment in cancer models.
Volume: 26
Issue: 7
Pages: 1125-1134
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Publication
27835580 | J:312832
First Author: Cho YH
Year: 2016
Journal: Oncotarget
Title: KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer.
Volume: 7
Issue: 49
Pages: 81727-81740
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Publication
34788095 | J:315124
First Author: Heino S
Year: 2021
Journal: Sci Adv
Title: Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Volume: 7
Issue: 47
Pages: eabj0512
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Publication
35020425 | J:319646
First Author: Chinnappa K
Year: 2022
Journal: Sci Adv
Title: Secondary loss of miR-3607 reduced cortical progenitor amplification during rodent evolution.
Volume: 8
Issue: 2
Pages: eabj4010
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Publication
32597939 | J:313061
 
First Author: Efimova N
Year: 2020
Journal: J Cell Biol
Title: Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion.
Volume: 219
Issue: 9
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Publication
36989360 | J:334477
First Author: Bala P
Year: 2023
Journal: Sci Adv
Title: Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation.
Volume: 9
Issue: 13
Pages: eadf0927
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Publication
28459449 | J:344121
First Author: Roper J
Year: 2017
Journal: Nat Biotechnol
Title: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.
Volume: 35
Issue: 6
Pages: 569-576
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Publication
10700176 | -
First Author: Satoh S
Year: 2000
Journal: Nat Genet
Title: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.
Volume: 24
Issue: 3
Pages: 245-50
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Protein Domain
IPR015669 | Endothetial_C_recpt
Type: Family
Description: Upon vascular injury, flowing blood is exposed to cells expressing tissue factor (TF) on their surfaces and FVII/FVIIa binds to its receptor/cofactor TF and is rapidly activated to FVIIa and the activity of bound FVIIa is dramatically enhanced. The TF/FVIIa complex activates zymogens factor X (FX) and factor IX (FIX). The FXa, in the absence of activated cofactor factor Va (FVa) generates only trace amounts of thrombin. Although insufficient to initiate fibrin polymerisation alone, these small amounts of thrombin, however, back activate factors V (FV), VIII (FVIII), and XI(FXI). FVIII and FV function as membrane-bound cofactors for proteinases FIXa and FXa, respectively increasing the Vmax of the reaction complexes dramatically. Amplification of the pro-coagulant response consequently occurs through formation of the tenase complex FIXa/FVIIIa and the thrombinase complex FXa/FVa that generate sufficient amounts of thrombin to mediate sustained haemostasis.In addition to its function in cleaving soluble fibrinogen to form insoluble fibrin monomers, thrombin can also activate an anticoagulant pathway. Thrombomodulin (TM), a receptor present on the endothelial cell surface, binds thrombin and alters thrombin's substrate specificity through an allosteric mechanism. Bound to TM, thrombin can no longer efficiently proteolyse its pro-coagulant substrates FV, FVIII and fibrinogen. The thrombin-TM complex proteolytically activates its substrate protein C (PC) to activated protein C (APC). In complex with its cofactor protein S (PS), APC rapidly inactivates pro-coagulant factors FVa and FVIIIa by further proteolysis in a negative feedback loop. Activation of protein C by thrombin bound to thrombomodulin is enhanced by endothelial protein C receptor (EPCR). The EPCR is an N-glycosylated type I membrane protein and mutations in this EPCR gene have been associated with venous thromboembolism and myocardial infarction, as well as with late foetal loss during pregnancy.
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Protein
Q9CPX9
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: false
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Protein
Q9Z1K7
Organism: Mus musculus/domesticus
Length: 2274  
Fragment?: false
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Protein
D3YTR0
Organism: Mus musculus/domesticus
Length: 2303  
Fragment?: false
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Protein
G5E832
Organism: Mus musculus/domesticus
Length: 2274  
Fragment?: false
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Protein Coding Gene
MGI:1926790 | Fzr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929711 | Anapc7
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28266561 | J:275078
 
First Author: Minocha S
Year: 2017
Journal: Sci Rep
Title: Nkx2.1 regulates the generation of telencephalic astrocytes during embryonic development.
Volume: 7
Pages: 43093
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Publication
31944179 | J:288791
   
First Author: Zhou L
Year: 2020
Journal: Elife
Title: Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination.
Volume: 9
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Publication
23318450 | J:204871
First Author: Solga AC
Year: 2014
Journal: Oncogene
Title: NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma.
Volume: 33
Issue: 3
Pages: 289-99
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Publication
18045844 | J:129201
First Author: Zhu X
Year: 2008
Journal: Development
Title: NG2 cells generate both oligodendrocytes and gray matter astrocytes.
Volume: 135
Issue: 1
Pages: 145-57
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Publication
25186737 | J:216135
First Author: Palazuelos J
Year: 2014
Journal: J Neurosci
Title: TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination.
Volume: 34
Issue: 36
Pages: 11884-96
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Publication
21351161 | J:169748
First Author: Komitova M
Year: 2011
Journal: Glia
Title: NG2 cells are not a major source of reactive astrocytes after neocortical stab wound injury.
Volume: 59
Issue: 5
Pages: 800-9
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Publication
35798697 | J:342193
First Author: Sánchez-de la Torre A
Year: 2022
Journal: Cell Death Dis
Title: Cannabinoid CB(1) receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice.
Volume: 13
Issue: 7
Pages: 585
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Publication
26634440 | J:229322
First Author: Khan JA
Year: 2016
Journal: Science
Title: Fetal liver hematopoietic stem cell niches associate with portal vessels.
Volume: 351
Issue: 6269
Pages: 176-80
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Publication
21839917 | J:193884
First Author: Armulik A
Year: 2011
Journal: Dev Cell
Title: Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
Volume: 21
Issue: 2
Pages: 193-215
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Publication
32413329 | J:290853
First Author: Wei Q
Year: 2020
Journal: Dev Cell
Title: Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Volume: 53
Issue: 5
Pages: 503-513.e5
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Publication
26651999 | J:269506
   
First Author: Minocha S
Year: 2015
Journal: Elife
Title: NG2 glia are required for vessel network formation during embryonic development.
Volume: 4
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Publication
24598589 | J:213666
First Author: Grutzendler J
Year: 2014
Journal: Sci Transl Med
Title: Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation.
Volume: 6
Issue: 226
Pages: 226ra31
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Publication
33859199 | J:306427
First Author: Sherafat A
Year: 2021
Journal: Nat Commun
Title: Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor.
Volume: 12
Issue: 1
Pages: 2265
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Publication
32788726 | J:296978
First Author: Alarcon-Martinez L
Year: 2020
Journal: Nature
Title: Interpericyte tunnelling nanotubes regulate neurovascular coupling.
Volume: 585
Issue: 7823
Pages: 91-95
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Publication
36574295 | J:334448
 
First Author: Romanò N
Year: 2023
Journal: JCI Insight
Title: Median eminence blood flow influences food intake by regulating ghrelin access to the metabolic brain.
Volume: 8
Issue: 3
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Publication
32424539 | J:294914
First Author: Mateus Gonçalves L
Year: 2020
Journal: Diabetologia
Title: Islet pericytes convert into profibrotic myofibroblasts in a mouse model of islet vascular fibrosis.
Volume: 63
Issue: 8
Pages: 1564-1575
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Publication
37752954 | J:341183
First Author: Tong L
Year: 2023
Journal: iScience
Title: Single cell in vivo optogenetic stimulation by two-photon excitation fluorescence transfer.
Volume: 26
Issue: 10
Pages: 107857
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Publication
28504673 | J:243962
First Author: Damisah EC
Year: 2017
Journal: Nat Neurosci
Title: A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging.
Volume: 20
Issue: 7
Pages: 1023-1032
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Publication
27683416 | J:237355
First Author: Urrutia AA
Year: 2016
Journal: Blood
Title: Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes.
Volume: 128
Issue: 21
Pages: 2550-2560
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Publication
31130357 | J:289296
First Author: Hanoun M
Year: 2019
Journal: Stem Cell Reports
Title: Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate.
Volume: 12
Issue: 6
Pages: 1201-1211
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Protein
F6Q1R4
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: true
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Publication
8297211 | -
First Author: Niegemann E
Year: 1993
Journal: Arch Microbiol
Title: Molecular organization of the Escherichia coli gab cluster: nucleotide sequence of the structural genes gabD and gabP and expression of the GABA permease gene.
Volume: 160
Issue: 6
Pages: 454-60
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Publication
15067197 | -
First Author: Luo W
Year: 2004
Journal: Neurosignals
Title: Axin: a master scaffold for multiple signaling pathways.
Volume: 13
Issue: 3
Pages: 99-113
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Protein Domain
IPR008096 | CTLA4
Type: Family
Description: T cell-dependent immune processes require cell-surface interactions thatmediate the initiation, modulation and the ultimate course of the response.The specificity of T cell recognition is determined by the engagement of theT cell receptor (TCR) on T cells with cognate peptide-MHC complexes presented by antigen presenting cells (APCs). Additional signals arerequired to sustain and enhance T cell activity, the most important of whichis provided by the engagement of CD28 on T cells with its ligands B7-1(CD80) and B7-2 (CD86). By contrast, the interaction of B7 isoformswith cytotoxic T lymphocyte-associated molecule-4 CTLA-4, a CD28 homologue receptor on T cells (31% identity), provides inhibitory signals requiredfor down-regulation of the response, while it may also prevent T cell activation by weak TCR signals[, , , , ].Unlike CD28, which is not expressed on resting T cells, CTLA-4 is not detected on the cell surface until 24 hours after activation. In fact, Tcell activation leads to both increased CTLA4 gene expression andtrafficking of CTLA4 protein to the cell surface. In addition, CTLA-4exhibits an affinity for the B7 isoforms that is 10 to 100 times that forCD28. Covalent dimerisation of CTLA4 is required for its high bindingavidity, but each monomeric subunit also contains a binding site for CD80and CD86. It is likely that CTLA-4 directly competes with CD28 for bindingB7 and also directs the assembly of inhibitory signalling complexes thatlead to quiescence or anergy. Thus the balance between the opposing signals elicited by CD28 and CTLA-4 is central to the regulation of T cellresponsiveness and homeostasis. One mechanism by which CTLA-4 may performthis function is by regulating cell-cycle progression; by contrast with CD28, which down-regulates the cell-cycle inhibitor p27kip1, CTLA-4 prevents this degradation[, , ].Sequence comparison between human CTLA-4 and CD28 proteins suggests they arehomologous, with the highest of degree of similarity being in the juxta-membrane and cytoplasmic regions. In addition, the cytoplasmic domainsof human and murine CTLA-4 are identical, suggesting that this region hasimportant functional properties [].Typically, activation of T cells by TCR-engaging peptide-MHC is dramatically enhanced by interaction of the CD28 co-stimulatory receptor with its ligands CD80 (B7-1) and CD86 (B7-2) on the APC surface. Interestingly, CTLA-4 is transported from intracellular stores toward the region of the cell surface receiving activation signals. This suggests that binding of CD28 to its ligand may occur primarily at the centre of the mature immunological synapse, and that CTLA-4 may be transported to this site under certain circumstancesto block or reverse this effect.
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Protein
Q8BZQ7
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Protein
Q3U430
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
Q6P0W7
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
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Protein
Q6ZPR8
Organism: Mus musculus/domesticus
Length: 838  
Fragment?: true
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Publication
7513726 | J:18042
First Author: Chen C
Year: 1994
Journal: J Immunol
Title: Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.
Volume: 152
Issue: 10
Pages: 4929-36
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Publication
21930792 | J:178776
First Author: Draber P
Year: 2011
Journal: Mol Cell Biol
Title: SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Volume: 31
Issue: 22
Pages: 4550-62
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Publication
15526037 | J:94781
First Author: Paronetto MP
Year: 2004
Journal: EMBO J
Title: Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes.
Volume: 23
Issue: 23
Pages: 4649-59
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Publication
15140131 | J:128975
First Author: Hayashi T
Year: 2004
Journal: J Thromb Haemost
Title: Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions.
Volume: 2
Issue: 6
Pages: 949-61
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Publication
9616155 | J:48078
First Author: Yang TL
Year: 1998
Journal: Blood
Title: The structure and function of murine factor V and its inactivation by protein C.
Volume: 91
Issue: 12
Pages: 4593-9
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Publication
19880452 | J:157166
First Author: Jabbour M
Year: 2009
Journal: J Immunol
Title: Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression.
Volume: 183
Issue: 10
Pages: 6500-12
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Publication
11390480 | J:69871
First Author: Ling V
Year: 2001
Journal: J Immunol
Title: Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules.
Volume: 166
Issue: 12
Pages: 7300-8
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Publication
16709847 | J:131790
First Author: Maekawa A
Year: 2006
Journal: J Immunol
Title: Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC.
Volume: 176
Issue: 11
Pages: 6873-8
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Publication
15883173 | J:99213
First Author: Lin HH
Year: 2005
Journal: J Exp Med
Title: The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance.
Volume: 201
Issue: 10
Pages: 1615-25
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Publication
22174456 | J:180787
First Author: Chen ST
Year: 2012
Journal: J Immunol
Title: Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2.
Volume: 188
Issue: 2
Pages: 668-77
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Publication
20223764 | J:158667
First Author: Holt JE
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