Leucine zipper putative tumor suppressor 1 (LZTS1, FEZ1) plays a role in mitosis []. It is associated with assembled microtubules and is involved in the stabilization of active p34CDC2 (Cdk1) []. LZTS1 plays an important role in ensuring proper Cdk1 activity during M phase. By maintaining high levels of Cdk1 activity, it prevents chromosomes missegregation []. LZTS1 plays an important role in human carcinogenesis [, , ].
The leucine zipper tumor suppressor (LZTS) family members are thought to play roles in cell growth modulation, mitosis and cancer cell growth suppression [, ]. This entry includes the protein families LZTS 1-3 from animals. LZTS1 (also known as FEZ1) plays a role in mitosis []. It is associated with assembled microtubules and is involved in the stabilization of active p34CDC2 (Cdk1) []. LZTS2 (LAPSER1) interacts with p80 katanin and regulates katanin-mediated microtubule severing. It alters cell proliferation by regulating cytokinesis. It is localised to the centrosome and the midbody in mitotic cells and modulates beta-catenin signalling and localisation []. LZTS3 (ProSAP-interacting protein 1, ProSAPiP1) interacts with the PDZ domain of ProSAP2/Shank3, a scaffolding protein for components of the postsynaptic density (PSD) of excitatory brain synapses []. It also interacts with the postsynaptic protein Sipa1l3/SPAR3 [].
