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Search results 1 to 100 out of 108 for Tchh

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
7062 | TCHH
Type: gene
Organism: human
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Gene
613296 | TCHH
Type: gene
Organism: cattle
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Gene
717358 | TCHH
Type: gene
Organism: macaque, rhesus
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Gene
112205248 | TCHH
Type: gene
Organism: chimpanzee
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Gene
310588 | Tchh
Type: gene
Organism: rat
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Gene
483207 | TCHH
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:2177944 | Tchh
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR033200 | TCHH
Type: Family
Description: The trichohyalin gene is a member of the "fused"gene family. Trichohyalin is a large structural protein abundant in the inner root sheath (IRS) of anagenic (growing) hair follicles and other sites of hard cornification [, ]. It associates with intermediate filaments and associates in regular arrays with keratin intermediate filaments.In humans, a number of genes specifying structural proteins expressed late during epidermal differentiation have been identified and found to be clustered on chromosome 1q21. Therefore, this region is named the epidermal differentiation complex (EDC). The proteins encoded by the EDC genes can be classified into three groups: the precursor proteins of the CE, the S100 family and the "fused"gene family []. In some classification, the "fused gene"family is classified as a subgroup within the S100 gene family []. The "fused"gene family members contain EF hands and internal tandem repeats. It consists of profilaggrin, trichohyalin, repetin, hornerin, the profilaggrin-related protein and cornulin (encoded by c1orf10). They are associated with keratin intermediate filaments and partially cross-linked to the cell envelope (CE) [].
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Publication
9268637 | J:38585
First Author: Krieg P
Year: 1997
Journal: Genomics
Title: Repetin (Rptn), a new member of the "fused gene" subgroup within the S100 gene family encoding a murine epidermal differentiation protein.
Volume: 43
Issue: 3
Pages: 339-48
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Protein
A0A0B4J1F9
Organism: Mus musculus/domesticus
Length: 1599  
Fragment?: false
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Protein
Q3V203
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: true
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Protein
Q80VU1
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: true
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Publication
15854042 | -
First Author: Huber M
Year: 2005
Journal: J Invest Dermatol
Title: Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex.
Volume: 124
Issue: 5
Pages: 998-1007
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Publication
22261007 | -
First Author: Takase T
Year: 2012
Journal: J Dermatol Sci
Title: Identification of the C-terminal tail domain of AHF/trichohyalin as the critical site for modulation of the keratin filamentous meshwork in the keratinocyte.
Volume: 65
Issue: 2
Pages: 141-8
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Publication
24780931 | J:215938
First Author: Mlitz V
Year: 2014
Journal: J Invest Dermatol
Title: Trichohyalin-like proteins have evolutionarily conserved roles in the morphogenesis of skin appendages.
Volume: 134
Issue: 11
Pages: 2685-2692
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Protein Coding Gene
MGP_CAROLIEiJ_G0025301 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027534 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027499 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027246 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2177944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027951 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026694 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027222 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027359 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027328 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027469 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027354 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028010 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026777 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026744 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026243 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
14597673 | J:98694
First Author: Takebe K
Year: 2003
Journal: FASEB J
Title: Epimorphin acts to induce hair follicle anagen in C57BL/6 mice.
Volume: 17
Issue: 14
Pages: 2037-47
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Publication
12853460 | J:86175
First Author: Steinert PM
Year: 2003
Journal: J Biol Chem
Title: Trichohyalin mechanically strengthens the hair follicle: multiple cross-bridging roles in the inner root shealth.
Volume: 278
Issue: 42
Pages: 41409-19
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GXD Expression
GXD Expression
   
Probe: MGI:7441986
Assay Type: RT-PCR
Annotation Date: 2023-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718527
Stage: TS27
Assay Id: MGI:7442102
Age: postnatal day 0
Image: 8
Specimen Label: control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7441986
Assay Type: RT-PCR
Annotation Date: 2023-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718527
Stage: TS27
Assay Id: MGI:7442102
Age: postnatal day 0
Image: 8
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2010-10-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1887326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4834816
Age: embryonic day 18.5
Image: 3F
Specimen Label: 3F
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1887328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5752215
Age: postnatal day 21
Note: Expression is in keratinocytes.
Specimen Label: 1G
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1887327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7442085
Age: postnatal day 0
Image: 5G/G'
Specimen Label: 5G/G'
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1887327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7442085
Age: postnatal day 0
Image: 5G/G'
Specimen Label: 5G/G'
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1887327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7442085
Age: postnatal day 0
Image: 5H/H'
Note: Drastically decreased expression compared with the wild-type.
Specimen Label: 5H/H'
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1887327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7442085
Age: postnatal day 0
Image: 5H/H'
Note: Drastically decreased expression compared with the wild-type.
Specimen Label: 5H/H'
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3585028
Stage: TS28
Assay Id: MGI:5752215
Age: postnatal day 21
Specimen Label: 1G
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2016-04-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5760380
Age: postnatal day 6
Note: Expressed in the medulla trichohyalin.
Specimen Label: 2D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7367159
Age: postnatal day 10
Image: S4 WT
Specimen Label: S4 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7367159
Age: postnatal day 10
Image: S4 KO
Note: Similar as in the wild-type.
Specimen Label: S4 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484031
Age: postnatal day 7
Image: 3E wt
Specimen Label: 3E wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484031
Age: postnatal day 7
Image: 3E Kras
Specimen Label: 3E Kras
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1827228
Stage: TS28
Assay Id: MGI:5752215
Age: postnatal day 21
Specimen Label: 1G
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2016-04-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5760380
Age: postnatal day 6
Specimen Label: 2D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7367159
Age: postnatal day 10
Image: S4 WT
Specimen Label: S4 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2022-10-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7367159
Age: postnatal day 10
Image: S4 KO
Note: Similar as in the wild-type.
Specimen Label: S4 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484031
Age: postnatal day 7
Image: 3E wt
Specimen Label: 3E wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3694079
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3279228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7484031
Age: postnatal day 7
Image: 3E Kras
Specimen Label: 3E Kras
Detected: true
Specimen Num: 2
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Publication
27287879 | J:234993
First Author: Nishiguchi Y
Year: 2016
Journal: Dev Biol
Title: Bcl11b/Ctip2 is required for development of lingual papillae in mice.
Volume: 416
Issue: 1
Pages: 98-110
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Publication
9565599 | J:74930
First Author: Steinert PM
Year: 1998
Journal: J Biol Chem
Title: Biochemical evidence that small proline-rich proteins and trichohyalin function in epithelia by modulation of the biomechanical properties of their cornified cell envelopes.
Volume: 273
Issue: 19
Pages: 11758-69
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Publication
12923059 | J:85304
First Author: Kaufman CK
Year: 2003
Journal: Genes Dev
Title: GATA-3: an unexpected regulator of cell lineage determination in skin.
Volume: 17
Issue: 17
Pages: 2108-22
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Publication
19038788 | J:197594
First Author: Okubo T
Year: 2009
Journal: Stem Cells
Title: Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate.
Volume: 27
Issue: 2
Pages: 442-50
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Publication
24309208 | J:205498
First Author: Tsai SY
Year: 2014
Journal: Dev Biol
Title: Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation.
Volume: 385
Issue: 2
Pages: 179-88
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Publication
17011173 | J:116050
First Author: Raveh E
Year: 2006
Journal: Mech Dev
Title: Dynamic expression of Runx1 in skin affects hair structure.
Volume: 123
Issue: 11
Pages: 842-50
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Publication
22763785 | J:191599
First Author: Li J
Year: 2012
Journal: J Invest Dermatol
Title: Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1.
Volume: 132
Issue: 12
Pages: 2681-90
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Publication
17015430 | J:112945
First Author: Okubo T
Year: 2006
Journal: Genes Dev
Title: Sox2 is required for development of taste bud sensory cells.
Volume: 20
Issue: 19
Pages: 2654-9
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Publication
19786578 | J:163216
First Author: Van Keymeulen A
Year: 2009
Journal: J Cell Biol
Title: Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis.
Volume: 187
Issue: 1
Pages: 91-100
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Publication
24222445 | J:263240
First Author: Kandyba E
Year: 2014
Journal: Stem Cells
Title: Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling.
Volume: 32
Issue: 4
Pages: 886-901
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Publication
16462742 | J:106792
First Author: Yi R
Year: 2006
Journal: Nat Genet
Title: Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.
Volume: 38
Issue: 3
Pages: 356-62
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Publication
14610062 | J:86539
First Author: Kobielak K
Year: 2003
Journal: J Cell Biol
Title: Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.
Volume: 163
Issue: 3
Pages: 609-23
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Publication
17991461 | J:129101
First Author: Xu X
Year: 2007
Journal: Dev Biol
Title: Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells.
Volume: 312
Issue: 2
Pages: 484-500
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Publication
22995554 | J:190629
First Author: Niimori D
Year: 2012
Journal: Dev Biol
Title: Tsukushi controls the hair cycle by regulating TGF-β1 signaling.
Volume: 372
Issue: 1
Pages: 81-7
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Publication
16901790 | J:115995
First Author: Horsley V
Year: 2006
Journal: Cell
Title: Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.
Volume: 126
Issue: 3
Pages: 597-609
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Publication
36630508 | J:332685
First Author: Chen GD
Year: 2023
Journal: Sci Adv
Title: DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation.
Volume: 9
Issue: 2
Pages: eabo7605
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Publication
16809539 | J:110119
First Author: Rhee H
Year: 2006
Journal: Science
Title: Lhx2 maintains stem cell character in hair follicles.
Volume: 312
Issue: 5782
Pages: 1946-9
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Publication
23178882 | J:195242
First Author: Youssef KK
Year: 2012
Journal: Nat Cell Biol
Title: Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.
Volume: 14
Issue: 12
Pages: 1282-94
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Publication
29899403 | J:267954
First Author: Nguyen MB
Year: 2018
Journal: Nat Commun
Title: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.
Volume: 9
Issue: 1
Pages: 2333
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Publication
20335364 | J:168262
First Author: Romano RA
Year: 2010
Journal: Development
Title: Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha.
Volume: 137
Issue: 9
Pages: 1431-9
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Publication
18684741 | J:140203
First Author: Hwang J
Year: 2008
Journal: Development
Title: Dlx3 is a crucial regulator of hair follicle differentiation and cycling.
Volume: 135
Issue: 18
Pages: 3149-59
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Publication
17151017 | J:117058
First Author: Kurek D
Year: 2007
Journal: Development
Title: Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles.
Volume: 134
Issue: 2
Pages: 261-72
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Publication
19956733 | J:161749
First Author: Mill P
Year: 2009
Journal: PLoS Genet
Title: Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.
Volume: 5
Issue: 11
Pages: e1000748
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Publication
19749746 | J:154022
First Author: Lopez RG
Year: 2009
Journal: Nat Cell Biol
Title: C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.
Volume: 11
Issue: 10
Pages: 1181-90
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Publication
28964716 | J:257520
First Author: Sardella C
Year: 2018
Journal: J Invest Dermatol
Title: Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.
Volume: 138
Issue: 3
Pages: 500-510
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Publication
23271346 | J:192592
First Author: Sotiropoulou PA
Year: 2013
Journal: Genes Dev
Title: BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
Volume: 27
Issue: 1
Pages: 39-51
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Publication
25546423 | J:228844
First Author: Leilei Y
Year: 2014
Journal: PLoS One
Title: iRhom2 mutation leads to aberrant hair follicle differentiation in mice.
Volume: 9
Issue: 12
Pages: e115114
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Publication
18593557 | J:207286
First Author: Nowak JA
Year: 2008
Journal: Cell Stem Cell
Title: Hair follicle stem cells are specified and function in early skin morphogenesis.
Volume: 3
Issue: 1
Pages: 33-43
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Publication
18824566 | J:143315
First Author: Wang X
Year: 2008
Journal: J Cell Biol
Title: AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.
Volume: 183
Issue: 1
Pages: 37-48
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Publication
19165927 | J:141958
First Author: Yang SH
Year: 2008
Journal: Nat Genet
Title: Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling.
Volume: 40
Issue: 9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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