Type |
Details |
Score |
Publication |
First Author: |
Sinadinos C |
Year: |
2014 |
Journal: |
Aging Cell |
Title: |
Neuronal glycogen synthesis contributes to physiological aging. |
Volume: |
13 |
Issue: |
5 |
Pages: |
935-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Valles-Ortega J |
Year: |
2011 |
Journal: |
EMBO Mol Med |
Title: |
Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease. |
Volume: |
3 |
Issue: |
11 |
Pages: |
667-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim M |
Year: |
2014 |
Journal: |
Circ Res |
Title: |
Mutation in the γ2-subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage. |
Volume: |
114 |
Issue: |
6 |
Pages: |
966-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nitschke S |
Year: |
2022 |
Journal: |
Brain |
Title: |
Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency. |
Volume: |
145 |
Issue: |
7 |
Pages: |
2361-2377 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pederson BA |
Year: |
2013 |
Journal: |
Ann Neurol |
Title: |
Inhibiting glycogen synthesis prevents Lafora disease in a mouse model. |
Volume: |
74 |
Issue: |
2 |
Pages: |
297-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2007 |
Journal: |
Arch Biochem Biophys |
Title: |
Glycogen metabolism in tissues from a mouse model of Lafora disease. |
Volume: |
457 |
Issue: |
2 |
Pages: |
264-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2006 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Relationship between glycogen accumulation and the laforin dual specificity phosphatase. |
Volume: |
350 |
Issue: |
3 |
Pages: |
588-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Augé E |
Year: |
2018 |
Journal: |
Glia |
Title: |
Astrocytes and neurons produce distinct types of polyglucosan bodies in Lafora disease. |
Volume: |
66 |
Issue: |
10 |
Pages: |
2094-2107 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bajaj NP |
Year: |
1997 |
Journal: |
J Neurochem |
Title: |
Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3alpha in transfected cells. |
Volume: |
69 |
Issue: |
2 |
Pages: |
737-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Doi M |
Year: |
2022 |
Journal: |
Front Endocrinol (Lausanne) |
Title: |
Prenatal methamphetamine exposure causes dysfunction in glucose metabolism and low birthweight. |
Volume: |
13 |
|
Pages: |
1023984 |
|
•
•
•
•
•
|
Publication |
First Author: |
Testoni G |
Year: |
2021 |
Journal: |
Hum Mol Genet |
Title: |
Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome. |
Volume: |
29 |
Issue: |
21 |
Pages: |
3554-3565 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mora A |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart. |
Volume: |
579 |
Issue: |
17 |
Pages: |
3632-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bouskila M |
Year: |
2010 |
Journal: |
Cell Metab |
Title: |
Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle. |
Volume: |
12 |
Issue: |
5 |
Pages: |
456-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitra S |
Year: |
2023 |
Journal: |
Dis Model Mech |
Title: |
Laforin targets malin to glycogen in Lafora progressive myoclonus epilepsy. |
Volume: |
16 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Fujii N |
Year: |
2004 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. |
Volume: |
287 |
Issue: |
1 |
Pages: |
C200-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Antos CL |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. |
Volume: |
99 |
Issue: |
2 |
Pages: |
907-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vilchez D |
Year: |
2007 |
Journal: |
Nat Neurosci |
Title: |
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1407-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seldin MF |
Year: |
1994 |
Journal: |
J Clin Invest |
Title: |
Glycogen synthase: a putative locus for diet-induced hyperglycemia. |
Volume: |
94 |
Issue: |
1 |
Pages: |
269-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng A |
Year: |
2007 |
Journal: |
Genes Dev |
Title: |
A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. |
Volume: |
21 |
Issue: |
19 |
Pages: |
2399-409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan EH |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. |
Volume: |
65 |
Issue: |
22 |
Pages: |
10330-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cifuentes D |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver. |
Volume: |
283 |
Issue: |
9 |
Pages: |
5642-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wodarz A |
Year: |
1998 |
Journal: |
Annu Rev Cell Dev Biol |
Title: |
Mechanisms of Wnt signaling in development. |
Volume: |
14 |
|
Pages: |
59-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tunster SJ |
Year: |
2010 |
Journal: |
Mol Cell Biol |
Title: |
The imprinted Phlda2 gene regulates extraembryonic energy stores. |
Volume: |
30 |
Issue: |
1 |
Pages: |
295-306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eaton M |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction. |
Volume: |
15 |
Issue: |
1 |
Pages: |
e0226735 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheong H |
Year: |
2014 |
Journal: |
Autophagy |
Title: |
Analysis of a lung defect in autophagy-deficient mouse strains. |
Volume: |
10 |
Issue: |
1 |
Pages: |
45-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tunster SJ |
Year: |
2016 |
Journal: |
Dev Biol |
Title: |
Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. |
Volume: |
418 |
Issue: |
1 |
Pages: |
55-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayeuf-Louchart A |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation. |
Volume: |
29 |
Issue: |
6 |
Pages: |
1410-1418.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pitetti JL |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1003160 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roberts GAG |
Year: |
2020 |
Journal: |
Placenta |
Title: |
Characterising the dynamics of placental glycogen stores in the mouse. |
Volume: |
99 |
|
Pages: |
131-140 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bowman CE |
Year: |
2016 |
Journal: |
Mol Cell Biol |
Title: |
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. |
Volume: |
36 |
Issue: |
15 |
Pages: |
2089-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Y |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
Volume: |
12 |
Issue: |
9 |
Pages: |
e1006355 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniPathway vocabulary mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
|
Allele |
Name: |
glycogen synthase 1, muscle; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Joan J Guinovart |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Constitutively active, Inserted expressed sequence |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
738
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
704
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
674
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
177
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
García-Rocha M |
Year: |
2001 |
Journal: |
Biochem J |
Title: |
Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes. |
Volume: |
357 |
Issue: |
Pt 1 |
Pages: |
17-24 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family consists of the eukaryotic glycogen synthase proteins GYS1 and GYS2. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P) []. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hprt1/? Myl1/Myl1<+> |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hprt1/? Tg(Nes-cre)1Kag/? |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Duran J |
Year: |
2012 |
Journal: |
EMBO Mol Med |
Title: |
Deleterious effects of neuronal accumulation of glycogen in flies and mice. |
Volume: |
4 |
Issue: |
8 |
Pages: |
719-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bultot L |
Year: |
2012 |
Journal: |
Biochem J |
Title: |
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. |
Volume: |
443 |
Issue: |
1 |
Pages: |
193-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Endoh M |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity. |
Volume: |
30 |
Issue: |
6 |
Pages: |
1823-1834.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Testoni G |
Year: |
2017 |
Journal: |
Cell Metab |
Title: |
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment. |
Volume: |
26 |
Issue: |
1 |
Pages: |
256-266.e4 |
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Publication |
First Author: |
Kakhlon O |
Year: |
2018 |
Journal: |
JCI Insight |
Title: |
Guaiacol as a drug candidate for treating adult polyglucosan body disease. |
Volume: |
3 |
Issue: |
17 |
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Publication |
First Author: |
Xirouchaki CE |
Year: |
2016 |
Journal: |
Mol Metab |
Title: |
Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice. |
Volume: |
5 |
Issue: |
3 |
Pages: |
221-232 |
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Publication |
First Author: |
Wang SC |
Year: |
2012 |
Journal: |
Biochem J |
Title: |
CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells. |
Volume: |
444 |
Issue: |
2 |
Pages: |
323-31 |
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