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Search results 101 to 200 out of 253 for Cyp7a1

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Type Details Score
Publication
11208732 | J:66998
First Author: Lammert F
Year: 2001
Journal: Gastroenterology
Title: Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.
Volume: 120
Issue: 1
Pages: 221-38
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
C7mlq<C57BL/6J> | MGI:3586685
 
Name: Cyp7a1 mRNA level QTL; C57BL/6J
Allele Type: QTL
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Allele
C7mlq<C3H/HeJ> | MGI:3586686
 
Name: Cyp7a1 mRNA level QTL; C3H/HeJ
Allele Type: QTL
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Publication
- | J:171109
     
First Author: Davis RA
Year: 2011
Journal: MGI Direct Data Submission
Title: A new transgenic mouse expressing rat Cyp7a1 in macrophages
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Publication
33424933 | J:310392
 
First Author: Xing C
Year: 2020
Journal: Front Genet
Title: Sleep Disturbance Induces Increased Cholesterol Level by NR1D1 Mediated CYP7A1 Inhibition.
Volume: 11
Pages: 610496
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Publication
14522988 | -
First Author: Shin DJ
Year: 2003
Journal: J Biol Chem
Title: PGC-1alpha activates CYP7A1 and bile acid biosynthesis.
Volume: 278
Issue: 50
Pages: 50047-52
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GO Term
GO:0008123 | cholesterol 7-alpha-monooxygenase activity
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Allele
Cyp7a1<em1Smoc> | MGI:7289257
Name: cytochrome P450, family 7, subfamily a, polypeptide 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475096 | C57BL/6-Cyp7a1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
24796972 | J:234226
First Author: Qi Y
Year: 2015
Journal: Biochim Biophys Acta
Title: Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.
Volume: 1851
Issue: 1
Pages: 19-29
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Publication
20623580 | J:340713
First Author: Li T
Year: 2010
Journal: Hepatology
Title: Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
Volume: 52
Issue: 2
Pages: 678-90
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Allele
Tg(APOE-Cyp7a1)1Road | MGI:3701768
Name: transgene insertion 1, Roger A Davis
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein Domain
IPR024204 | Cyt_P450_CYP7A1-type
Type: Family
Description: This group represents cytochrome P450, CYP7A1 type. Gene cyp7a1 codes for the enzyme cholesterol 7-alpha-monooxygenase, which catalyses a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. This enzyme is important for cholesterol homeostasis []. Some of the enzymes belonging to this group are 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, also involved in bile acid biosynthesis, and prostacyclin synthase, which catalyses the isomerization of prostaglandin H2 to prostacyclin (prostaglandin I2).
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Strain
MGI:4462245 | B6.Cg-Tg(APOE-Cyp7a1)1Road/Mmucd
Attribute String: transgenic, mutant strain, congenic
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Strain
MGI:5139994 | B6.Cg-Tg(APOE-Cyp7a1)1Road
Attribute String: transgenic, mutant strain, congenic
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Publication
11788471 | J:118722
First Author: Miyake JH
Year: 2002
Journal: Arterioscler Thromb Vasc Biol
Title: Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice.
Volume: 22
Issue: 1
Pages: 121-6
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Genotype
Genotype
Symbol: Tg(APOE-Cyp7a1)1Road/?
Background: B6.Cg-Tg(APOE-Cyp7a1)1Road
Zygosity: ot
Has Mutant Allele: true
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Allele
Tg(RP23-291P1)1Flp | MGI:2386569
Name: transgene insertion 1, Figge, Lammert and Paigen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(RP23-291P1)2Flp | MGI:2384355
Name: transgene insertion 2, Figge, Lammert and Paigen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
26997483 | J:234411
First Author: Okin D
Year: 2016
Journal: Cell
Title: The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia.
Volume: 165
Issue: 2
Pages: 343-56
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Publication
16284190 | J:118817
First Author: Gutierrez A
Year: 2006
Journal: Arterioscler Thromb Vasc Biol
Title: Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4.
Volume: 26
Issue: 2
Pages: 301-6
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Publication
15650132 | J:128561
First Author: Sundaram SS
Year: 2005
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet.
Volume: 288
Issue: 6
Pages: G1321-7
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Publication
16341669 | J:104062
First Author: Henkel A
Year: 2005
Journal: Mamm Genome
Title: Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones.
Volume: 16
Issue: 12
Pages: 903-8
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Publication
20456485 | J:308408
First Author: Wang HH
Year: 2010
Journal: Eur J Clin Invest
Title: Transgenic overexpression of Abcb11 enhances biliary bile salt outputs, but does not affect cholesterol cholelithogenesis in mice.
Volume: 40
Issue: 6
Pages: 541-51
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Genotype
Genotype
Symbol: Tg(RP23-291P1)1Flp/?
Background: involves: 129S1/SvImJ * FVB/NJ
Zygosity: ot
Has Mutant Allele: true
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HT Experiment
E-GEOD-20599 | Gene expression analysis of FXR null, SHP null, and double FXR/SHP null mice
Series Id: GSE20599
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
14570929 | J:94496
First Author: Figge A
Year: 2004
Journal: J Biol Chem
Title: Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis.
Volume: 279
Issue: 4
Pages: 2790-9
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Publication
16213224 | J:129677
First Author: Inagaki T
Year: 2005
Journal: Cell Metab
Title: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Volume: 2
Issue: 4
Pages: 217-25
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Publication
19956992 | J:289377
First Author: Pirinen E
Year: 2010
Journal: Amino Acids
Title: Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis.
Volume: 38
Issue: 2
Pages: 549-60
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Publication
16516849 | J:107072
First Author: Wang J
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice.
Volume: 342
Issue: 4
Pages: 1382-8
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Publication
12062084 | J:102129
First Author: Kerr TA
Year: 2002
Journal: Dev Cell
Title: Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis.
Volume: 2
Issue: 6
Pages: 713-20
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Publication
37696161 | J:341197
First Author: Zhou C
Year: 2023
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Fibroblast growth factor 21 ameliorates cholestatic liver injury via a hepatic FGFR4-JNK pathway.
Volume: 1870
Issue: 1
Pages: 166870
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Publication
26615883 | J:274085
 
First Author: Lee EY
Year: 2015
Journal: Sci Rep
Title: Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.
Volume: 5
Pages: 17565
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Publication
11030332 | J:64755
First Author: Goodwin B
Year: 2000
Journal: Mol Cell
Title: A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
Volume: 6
Issue: 3
Pages: 517-26
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Publication
30745141 | J:272595
First Author: Ji S
Year: 2019
Journal: Dev Cell
Title: FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis.
Volume: 48
Issue: 4
Pages: 460-474.e9
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Publication
28041926 | J:278381
 
First Author: Zhang J
Year: 2017
Journal: EBioMedicine
Title: Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action.
Volume: 15
Pages: 173-183
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Publication
18292224 | J:132778
First Author: Rao A
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis.
Volume: 105
Issue: 10
Pages: 3891-6
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Publication
19805516 | J:154989
First Author: Miao J
Year: 2009
Journal: Mol Cell Biol
Title: Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.
Volume: 29
Issue: 23
Pages: 6170-81
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Publication
19237543 | J:149773
First Author: Shin DJ
Year: 2009
Journal: J Biol Chem
Title: FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.
Volume: 284
Issue: 17
Pages: 11110-20
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Publication
16075061 | J:100209
First Author: Ito S
Year: 2005
Journal: J Clin Invest
Title: Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho.
Volume: 115
Issue: 8
Pages: 2202-8
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Publication
18565334 | J:141770
First Author: Duez H
Year: 2008
Journal: Gastroenterology
Title: Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha.
Volume: 135
Issue: 2
Pages: 689-98
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Publication
23614904 | J:200728
First Author: Parker RA
Year: 2013
Journal: J Lipid Res
Title: Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression.
Volume: 54
Issue: 9
Pages: 2400-9
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Publication
24755711 | J:215174
First Author: Lou G
Year: 2014
Journal: PLoS One
Title: GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells.
Volume: 9
Issue: 4
Pages: e93567
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Publication
17971517 | J:131221
First Author: Kudo T
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.
Volume: 294
Issue: 1
Pages: E120-30
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Publication
35657825 | J:328526
First Author: Lynch EC
Year: 2022
Journal: PLoS One
Title: Disrupting Osr1 expression promoted hepatic steatosis and inflammation induced by high-fat diet in the mouse model.
Volume: 17
Issue: 6
Pages: e0268344
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Publication
18820241 | J:149005
First Author: Hartman HB
Year: 2009
Journal: J Lipid Res
Title: Loss of small heterodimer partner expression in the liver protects against dyslipidemia.
Volume: 50
Issue: 2
Pages: 193-203
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Publication
22542490 | J:320452
First Author: Lan T
Year: 2012
Journal: J Hepatol
Title: Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism.
Volume: 57
Issue: 2
Pages: 359-65
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Publication
26372644 | J:243180
First Author: Fu ZD
Year: 2015
Journal: PLoS One
Title: The Role of Sirt1 in Bile Acid Regulation during Calorie Restriction in Mice.
Volume: 10
Issue: 9
Pages: e0138307
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Publication
27895309 | J:298387
First Author: Lemberger UJ
Year: 2016
Journal: Oncotarget
Title: Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease.
Volume: 7
Issue: 52
Pages: 86985-86998
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Publication
23087171 | J:192628
First Author: Lin JZ
Year: 2012
Journal: Endocrinology
Title: Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor.
Volume: 153
Issue: 12
Pages: 6136-44
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Publication
22185956 | J:182449
First Author: Gessner DK
Year: 2012
Journal: Biochim Biophys Acta
Title: Increased plasma thyroid hormone concentrations in LDL receptor deficient mice may be explained by inhibition of aryl hydrocarbon receptor-dependent expression of hepatic UDP-glucuronosyltransferases.
Volume: 1820
Issue: 4
Pages: 495-502
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Publication
17761942 | J:135003
First Author: Heverin M
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.
Volume: 27
Issue: 10
Pages: 2191-7
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Publication
24421394 | J:213532
First Author: Ramakrishnan SK
Year: 2014
Journal: Mol Cell Biol
Title: Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis.
Volume: 34
Issue: 7
Pages: 1208-20
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Publication
22467244 | J:293604
First Author: Kong B
Year: 2012
Journal: Hepatology
Title: Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice.
Volume: 56
Issue: 3
Pages: 1034-43
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Publication
28891815 | J:247719
First Author: Tarling EJ
Year: 2017
Journal: J Clin Invest
Title: RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.
Volume: 127
Issue: 10
Pages: 3741-3754
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Publication
16264196 | J:107562
First Author: Wang J
Year: 2006
Journal: J Lipid Res
Title: Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.
Volume: 47
Issue: 2
Pages: 421-30
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Publication
29191818 | J:277988
 
First Author: Zurkinden L
Year: 2018
Journal: Biosci Rep
Title: Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice.
Volume: 38
Issue: 1
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Publication
34936222 | J:345067
First Author: Cingolani F
Year: 2022
Journal: Hepatol Commun
Title: Redundant Functions of ERK1 and ERK2 Maintain Mouse Liver Homeostasis Through Down-Regulation of Bile Acid Synthesis.
Volume: 6
Issue: 5
Pages: 980-994
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Publication
19706524 | J:151994
First Author: Wu X
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice.
Volume: 106
Issue: 34
Pages: 14379-84
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Publication
18323469 | J:135822
First Author: Lee YK
Year: 2008
Journal: Mol Endocrinol
Title: Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Volume: 22
Issue: 6
Pages: 1345-56
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Publication
22981383 | J:291260
First Author: Kim EH
Year: 2012
Journal: Biochem Pharmacol
Title: Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease.
Volume: 84
Issue: 10
Pages: 1359-65
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