Leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1) interacts with p80 katanin and regulates katanin-mediated microtubule severing []. It is localised to the centrosome and the midbody in mitotic cells. During prophase, LAPSER1/LZTS2 inhibits centrosomal gamma-tubulin accumulation, which results in retardation of mitotic entry. During interphase, LAPSER1/LZTS2 inhibits katanin, which results in prevention of cell motility []. LAPSER1/LZTS2 also modulates beta-catenin signaling and localisation []. LAPSER1/LZTS2 has been identified as a candidate tumor suppressor gene in prostate cancer [].
The leucine zipper tumor suppressor (LZTS) family members are thought to play roles in cell growth modulation, mitosis and cancer cell growth suppression [, ]. This entry includes the protein families LZTS 1-3 from animals. LZTS1 (also known as FEZ1) plays a role in mitosis []. It is associated with assembled microtubules and is involved in the stabilization of active p34CDC2 (Cdk1) []. LZTS2 (LAPSER1) interacts with p80 katanin and regulates katanin-mediated microtubule severing. It alters cell proliferation by regulating cytokinesis. It is localised to the centrosome and the midbody in mitotic cells and modulates beta-catenin signalling and localisation []. LZTS3 (ProSAP-interacting protein 1, ProSAPiP1) interacts with the PDZ domain of ProSAP2/Shank3, a scaffolding protein for components of the postsynaptic density (PSD) of excitatory brain synapses []. It also interacts with the postsynaptic protein Sipa1l3/SPAR3 [].
