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Search results 101 to 141 out of 141 for Otulin

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Type Details Score
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Ubiquitin thioesterase otulin
Type: chain
End: 352
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Protein
A0A2I3BRS5
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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HT Experiment
GSE180024 | Otulin inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
24726327 | -
First Author: Schaeffer V
Year: 2014
Journal: Mol Cell
Title: Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.
Volume: 54
Issue: 3
Pages: 349-61
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Allele
Otulin<em1Smoc> | MGI:7291494
Name: OTU deubiquitinase with linear linkage specificity; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Shi R (2021)
Description: SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-?B signalling activation.
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Publication
34315543 | -
First Author: Shi R
Year: 2021
Journal: Cell Biosci
Title: SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.
Volume: 11
Issue: 1
Pages: 146
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DO Term
DOID:0080163 | otulipenia
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Publication
27460922 | -
 
First Author: Zhu J
Year: 2016
Journal: BMC Cancer
Title: Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression.
Volume: 16
Pages: 538
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Publication
24726323 | -
First Author: Elliott PR
Year: 2014
Journal: Mol Cell
Title: Molecular basis and regulation of OTULIN-LUBAC interaction.
Volume: 54
Issue: 3
Pages: 335-48
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Protein Domain
IPR040641 | RNF31_PUB
Type: Domain
Description: This is a PUB domain (PNGase/UBA- or UBX-containing domain), found in E3 ubiquitin-protein ligase RNF31, also known as Ring finger protein 31 and HOIL-1-interacting protein (HOIP) []. RNF31/HOIP has been shown to contribute to inborn human immunity disorders, in which RNF31/HOIP missense mutation at PUB domain gives rise to the de-stabilized LUBAC complex (linear ubiquitin chain assembly complex) and subsequently causes the auto-inflammation and immunodeficiency. In addition, RNF31 is reported to modify ERK and JNK pathways leading to cisplatin resistance []. Functional studies indicate that HOIP and OTULIN interact and act as a bimolecular editing pair for linear ubiquitin signals where the HOIP-PUB domain binds to the PUB interacting motif (PIM) of OTULIN and the chaperone VCP/p9. This interaction plays an important role where the HOIP binding to OTULIN is required for the recruitment of OTULIN to the TNF receptor complex and to counteract HOIP-dependent activation of the NF-KB pathway [, ].
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Protein Domain
IPR023235 | FAM105
Type: Family
Description: This entry represents the FAM105 family, including FAM105A (OTULINL) and FAM105B (OTULIN). Otulin is an ubiquitin thioesterase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response []. FAM105A shares a high degree of similarity with protein otulin; however, FAM105A lacks the conserved active site at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity [].
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Publication
32123171 | J:286745
First Author: Zuo Y
Year: 2020
Journal: Nat Commun
Title: Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Volume: 11
Issue: 1
Pages: 1146
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Publication
36640323 | J:333003
First Author: Griewahn L
Year: 2023
Journal: Cell Rep
Title: SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.
Volume: 42
Issue: 1
Pages: 111961
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Publication
31541095 | J:279367
First Author: Stangl A
Year: 2019
Journal: Nat Commun
Title: Regulation of the endosomal SNX27-retromer by OTULIN.
Volume: 10
Issue: 1
Pages: 4320
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Protein
Q3TVP5
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
Q3UY70
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: true
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Protein
A0A2I3BPS6
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
A0A2I3BQU9
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Publication
24576094 | -
First Author: Spratt DE
Year: 2014
Journal: Biochem J
Title: RBR E3 ubiquitin ligases: new structures, new insights, new questions.
Volume: 458
Issue: 3
Pages: 421-37
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Protein
Q924T7
Organism: Mus musculus/domesticus
Length: 1066  
Fragment?: false
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Protein
Q6WIZ9
Organism: Mus musculus/domesticus
Length: 1067  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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