This transcriptional activator is known as ETS translocation variant 1 (ETV1) or Ets-related protein 81 (ER81). It is a member of the larger E-twenty six (Ets) family whose members bind DNA directly via a conserved Ets domain []. ETV1 contributes to the formation of dopaminergic neurons []and also contributes to formation of proper connections between group 1a sensory afferents and motor neurons []. It is an oncoprotein implicated in Ewing tumours and different types of cancer [, ].
This entry represents ETS family of transcription factors, including ETS translocation variant 1-5 (ETV1-5) and related proteins from animals. Most members of this protein family contain an ETS (erythroblast transformation specific) domain and belong to the winged helix DNA-binding domain superfamily.ETV1-5 are overexpressed in multiple cancers [, , ]. ETV1 is critical for fast conduction physiology in the heart []. ETV3 is a transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation []. ETV4 is a transcriptional activator that may play a role in keratinocyte differentiation [, ].
