|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 165 out of 165 for Paf1

<< First    < Previous  |  Next >    Last >>
0.022s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
20178742 | -
First Author: Kim J
Year: 2010
Journal: Cell
Title: The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
Volume: 140
Issue: 4
Pages: 491-503
•
•
•
•
•
GO Term
GO:0016593 | Cdc73/Paf1 complex
•
•
•
•
•
Publication
36180487 | J:329446
First Author: Nimmakayala RK
Year: 2022
Journal: Cell Death Dis
Title: PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer.
Volume: 13
Issue: 10
Pages: 839
•
•
•
•
•
Protein
Q8K2T8
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
•
•
•
•
•
Publication
16491129 | -
First Author: Moniaux N
Year: 2006
Journal: Oncogene
Title: The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.
Volume: 25
Issue: 23
Pages: 3247-57
•
•
•
•
•
Publication
22419161 | -
First Author: Marazzi I
Year: 2012
Journal: Nature
Title: Suppression of the antiviral response by an influenza histone mimic.
Volume: 483
Issue: 7390
Pages: 428-33
•
•
•
•
•
Protein Domain
IPR007133 | RNA_pol_II-assoc_Paf1
Type: Family
Description: In budding yeasts, Paf1 is part of the Paf1 complex, an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1 []. Paf1 complex is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection []. This entry also includes Paf1 homologues from animals and plants. Human Paf1, also known as PD2 (pancreatic differentiation 2), is associated with tumorigenesis []. Human Paf1 complex (Paf1C) consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications []. Human Paf1 complex has a crucial role in the antiviral response []. Arabidopsis Paf1C related proteins such as VIP4 (Leo1), VIP5 (Rtf1), ELF7 (Paf1), ELF8 (Ctr9) and ATXR7 (Set1) are required for the induction of seed dormancy. They control both germination and flowering time [].
•
•
•
•
•
Publication
15580289 | -
First Author: Woodard GE
Year: 2005
Journal: Oncogene
Title: Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression.
Volume: 24
Issue: 7
Pages: 1272-6
•
•
•
•
•
Publication
16989776 | -
First Author: Zhang C
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Parafibromin inhibits cancer cell growth and causes G1 phase arrest.
Volume: 350
Issue: 1
Pages: 17-24
•
•
•
•
•
Protein Domain
IPR032041 | Cdc73_N
Type: Domain
Description: This is the N-terminal region of Cdc73 (cell division cycle 73). Cdc73 forms part of the Paf1 post-initiation complex []. As part of the Paf1 complex, Cdc73 associates with RNA-polymerase II and is involved in several transcriptional and posttranscriptional events. In vertebrates, the protein encoded by HRPT2/CCdc73 is known as Parafibromin, and acts as a tumour suppressor [, ].
•
•
•
•
•
Gene
446278 | paf1.L
Type: gene
Organism: frog, African clawed
•
•
•
•
•
Publication
11884586 | -
First Author: Mueller CL
Year: 2002
Journal: Mol Cell Biol
Title: Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex.
Volume: 22
Issue: 7
Pages: 1971-80
•
•
•
•
•
Publication
1913663 | -
First Author: Isom H
Year: 1991
Journal: Cancer Res
Title: Workshop report from the Division of Research Grants, National Institutes of Health. The role of chromosome rearrangements, deletions, and point mutations in cancer--a Pathology B Study Section workshop.
Volume: 51
Issue: 19
Pages: 5440-4
•
•
•
•
•
Publication
21799800 | -
First Author: Liu Y
Year: 2011
Journal: PLoS One
Title: Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a role for the polymerase associated factor 1 complex in seed dormancy.
Volume: 6
Issue: 7
Pages: e22241
•
•
•
•
•
Allele
Paf1<em2Smoc> | MGI:7291518
Name: Paf1, RNA polymerase II complex component; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Publication
22318720 | -
First Author: Amrich CG
Year: 2012
Journal: J Biol Chem
Title: Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin.
Volume: 287
Issue: 14
Pages: 10863-75
•
•
•
•
•
Publication
9891041 | -
First Author: Chang M
Year: 1999
Journal: Mol Cell Biol
Title: A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling.
Volume: 19
Issue: 2
Pages: 1056-67
•
•
•
•
•
Protein
P55098
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
•
•
•
•
•
Publication
20363855 | -
First Author: Park S
Year: 2010
Journal: Plant Physiol
Title: PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regulating expression of genes within H3K27ME3-enriched chromatin.
Volume: 153
Issue: 2
Pages: 821-31
•
•
•
•
•
Protein
Q8JZM7
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
•
•
•
•
•
Interaction Experiment
Ding L (2009)
Description: A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
•
•
•
•
•
Allele
Paf1<em1Smoc> | MGI:7291517
Name: Paf1, RNA polymerase II complex component; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Publication
29774127 | -
First Author: Ropa J
Year: 2018
Journal: Oncotarget
Title: PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.
Volume: 9
Issue: 31
Pages: 22123-22136
•
•
•
•
•
Strain
MGI:6475951 | C57BL/6J-Paf1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Protein
Q5XJE5
Organism: Mus musculus/domesticus
Length: 667  
Fragment?: false
•
•
•
•
•
Protein
Q6IQZ4
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: false
•
•
•
•
•
Publication
15791002 | -
First Author: Zhao L
Year: 2005
Journal: FASEB J
Title: Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts.
Volume: 19
Issue: 6
Pages: 521-32
•
•
•
•
•
Publication
24385927 | -
First Author: Mbogning J
Year: 2013
Journal: PLoS Genet
Title: The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast.
Volume: 9
Issue: 12
Pages: e1004029
•
•
•
•
•
Protein Domain
IPR007149 | Leo1
Type: Family
Description: In budding yeasts, Leo1 is part of the Paf1 complex, an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1. Paf1 complex is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection []. This entry also includes Leo1 homologues from animals and plants. Human Leo1, also known as RDL, is a component of the human Paf1 complex (Paf1C), which consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications []. Human Leo1 promotes senescence of 2BS fibroblasts [].Arabidopsis Paf1C related proteins such as VIP4 (Leo1), VIP5 (Rtf1), ELF7 (Paf1), ELF8 (Ctr9) and ATXR7 (Set1) are required for the induction of seed dormancy. They control both germination and flowering time [].
•
•
•
•
•
Protein Domain
IPR031101 | Ctr9
Type: Family
Description: This entry includes budding yeast RNA polymerase-associated protein Ctr9 and its homologues from other yeasts, animals and plants. The homologue in fission yeast is known as tetratricopeptide repeat protein 1 (Tpr1) [].Budding yeast Ctr9 is part of the Paf1 complex, an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1 []. Paf1 complex is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection []. Human Paf1 complex (Paf1C) consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications [].Arabidopsis Paf1C related proteins such as VIP4 (Leo1), VIP5 (Rtf1), ELF7 (Paf1), ELF8 (Ctr9) and ATXR7 (Set1) are required for the induction of seed dormancy. They control both germination and flowering time [].
•
•
•
•
•
Protein Domain
IPR031336 | CDC73_C
Type: Domain
Description: CDC73 is an RNA polymerase II accessory factor [], and forms part of the Paf1 complex that has roles in post-initiation events []. More specifically, crystal structure analysis shows the C terminus to be a Ras-like domain that adopts a fold that is highly similar to GTPases of the Ras superfamily. The C-terminal domain contains a large but comparatively flat surface of highly conserved residues, devoid of ligand. Deletion of the Cdc73 C-domain significantly reduces Paf1C occupancy on active genes, which means that the Cdc73 C-domain plays a role in promoting association of Paf1C with chromatin []. The canonical nucleotide binding pocket is altered in CDC73, and there is no nucleotide ligand, but it contributes to histone methylation and Paf1 complex (Paf1C) recruitment to active genes. Thus, together with Rtf1, it combines to couple Paf1C to elongating polymerase [].
•
•
•
•
•
Protein Domain
IPR038103 | CDC73_C_sf
Type: Homologous_superfamily
Description: CDC73 is an RNA polymerase II accessory factor [], and forms part of the Paf1 complex that has roles in post-initiation events []. More specifically, crystal structure analysis shows the C terminus to be a Ras-like domain that adopts a fold that is highly similar to GTPases of the Ras superfamily. The C-terminal domain contains a large but comparatively flat surface of highly conserved residues, devoid of ligand. Deletion of the Cdc73 C-domain significantly reduces Paf1C occupancy on active genes, which means that the Cdc73 C-domain plays a role in promoting association of Paf1C with chromatin []. The canonical nucleotide binding pocket is altered in CDC73, and there is no nucleotide ligand, but it contributes to histone methylation and Paf1 complex (Paf1C) recruitment to active genes. Thus, together with Rtf1, it combines to couple Paf1C to elongating polymerase [].
•
•
•
•
•
Publication
8812838 | -
First Author: Wade PA
Year: 1996
Journal: Protein Expr Purif
Title: A novel collection of accessory factors associated with yeast RNA polymerase II.
Volume: 8
Issue: 1
Pages: 85-90
•
•
•
•
•
Publication
9032243 | -
First Author: Shi X
Year: 1997
Journal: Mol Cell Biol
Title: Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme.
Volume: 17
Issue: 3
Pages: 1160-9
•
•
•
•
•
Publication
12242279 | -
First Author: Krogan NJ
Year: 2002
Journal: Mol Cell Biol
Title: RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.
Volume: 22
Issue: 20
Pages: 6979-92
•
•
•
•
•
Publication
20463090 | -
First Author: Yu X
Year: 2010
Journal: Plant Physiol
Title: The Arabidopsis Paf1c complex component CDC73 participates in the modification of FLOWERING LOCUS C chromatin.
Volume: 153
Issue: 3
Pages: 1074-84
•
•
•
•
•
Protein Domain
IPR007852 | Cdc73/Parafibromin
Type: Family
Description: This entry includes Cdc73 from budding yeasts and its animal homologue, parafibromin. They are part of the Paf1 complex involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection [].In budding yeasts, Paf1 is an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1. It is required for full expression of a subset of yeast genes, particularly those responsive to signals from the Pkc1/MAP kinase cascade. The complex appears to play an essential role in RNA elongation []. Human parafibromin is a tumour suppressor that may facilitate association of 3' mRNA processing factors with actively-transcribed chromatin. It is a component of the human Paf1 complex (Paf1C), which consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications []. The Arabidopsis Cdc73 (also known as PLANT HOMOLOGOUS TO PARAFIBROMIN ,PHP) assists in regulating expression of genes within H3K27ME3-enriched chromatin []and participates in the modification of FLOWERING LOCUS C (FLC) chromatin [].
•
•
•
•
•
Protein
A2AQ19
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: false
•
•
•
•
•
Protein
Q3UXG8
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: true
•
•
•
•
•
Publication
11014804 | -
First Author: Costa PJ
Year: 2000
Journal: Genetics
Title: Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation.
Volume: 156
Issue: 2
Pages: 535-47
•
•
•
•
•
Publication
18184592 | -
First Author: de Jong RN
Year: 2008
Journal: Structure
Title: Structure and DNA binding of the human Rtf1 Plus3 domain.
Volume: 16
Issue: 1
Pages: 149-59
•
•
•
•
•
Publication
30455454 | J:271411
First Author: Deliu E
Year: 2018
Journal: Nat Neurosci
Title: Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition.
Volume: 21
Issue: 12
Pages: 1717-1727
•
•
•
•
•
Publication
34853439 | J:331164
First Author: Li M
Year: 2022
Journal: Leukemia
Title: SETD5 modulates homeostasis of hematopoietic stem cells by mediating RNA Polymerase II pausing in cooperation with HCF-1.
Volume: 36
Issue: 4
Pages: 1111-1122
•
•
•
•
•
HT Experiment
GSE119498 | Haploinsufficiency of the intellectual disability-gene SETD5 disturbs developmental gene expression and cognition
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Protein Domain
IPR004343 | Plus-3_dom
Type: Domain
Description: The yeast Paf1 complex consists of Pfa1, Rtf1, Cdc73, Ctr9, and Leo1. The complex regulates histone H2B ubiquitination, histone H3 methylation, RNA polymerase II carboxy-terminal domain (CTD) Ser2 phosphorylation, and RNA 3' end processing. The conservation of Paf1 complex function in higher eukaryotes has been confirmed in human cells, Drosophila and Arabidopsis. The Plus3 domain spans the most conserved regions of the Rtf1 protein and is surrounded by regions of low complexity and coiled-coil propensity []. It contains only a limited number of highly conserved amino acids, among which are three positively charged residues that gave the Plus3 domain its name. The capacity to bind single-stranded DNA is at least one function of the Plus3 domain [].The plus-3 domain is about 90 residues in length and is often found associated with the GYF domain (). The Plus3 domain structure consists of six alpha helices intervened by a sequence of six beta strands in a mixed alpha/beta topology. Beta strands 1, 2, 5, and 6 compose a four-stranded antiparallel beta sheet with a β-hairpin insertion formed by strands 3 and 4. The N-terminal helices alpha1-alpha3 and C-terminal helix alpha6 pack together to form an alpha subdomain, while the beta strands and the small 3(10) helix alpha 4 form a beta subdomain. The two subdomains pack together to form a compact, globular protein [].
•
•
•
•
•
Protein Domain
IPR036128 | Plus3-like_sf
Type: Homologous_superfamily
Description: The yeast Paf1 complex consists of Pfa1, Rtf1, Cdc73, Ctr9, and Leo1. The complex regulates histone H2B ubiquitination, histone H3 methylation, RNA polymerase II carboxy-terminal domain (CTD) Ser2 phosphorylation, and RNA 3' end processing. The conservation of Paf1 complex function in higher eukaryotes has been confirmed in human cells, Drosophila and Arabidopsis. The Plus3 domain spans the most conserved regions of the Rtf1 protein and is surrounded by regions of low complexity and coiled-coil propensity []. It contains only a limited number of highly conserved amino acids, among which are three positively charged residues that gave the Plus3 domain its name. The capacity to bind single-stranded DNA is at least one function of the Plus3 domain [].The plus-3 domain is about 90 residues in length and is often found associated with the GYF domain (). The Plus3 domain structure consists of six alpha helices intervened by a sequence of six beta strands in a mixed alpha/beta topology. Beta strands 1, 2, 5, and 6 compose a four-stranded antiparallel beta sheet with a β-hairpin insertion formed by strands 3 and 4. The N-terminal helices alpha1-alpha3 and C-terminal helix alpha6 pack together to form an alpha subdomain, while the beta strands and the small 3(10) helix alpha 4 form a beta subdomain. The two subdomains pack together to form a compact, globular protein [].
•
•
•
•
•
Publication
27864380 | J:237500
First Author: Osipovich AB
Year: 2016
Journal: Development
Title: Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.
Volume: 143
Issue: 24
Pages: 4595-4607
•
•
•
•
•
Publication
37233188 | J:338311
 
First Author: Langenbacher AD
Year: 2023
Journal: J Cardiovasc Dev Dis
Title: Rtf1 Transcriptionally Regulates Neonatal and Adult Cardiomyocyte Biology.
Volume: 10
Issue: 5
•
•
•
•
•
Publication
24420920 | J:209381
First Author: Yoo HS
Year: 2014
Journal: J Immunol
Title: Transcriptional regulator CTR9 inhibits Th17 differentiation via repression of IL-17 expression.
Volume: 192
Issue: 4
Pages: 1440-8
•
•
•
•
•
Protein
Q62018
Organism: Mus musculus/domesticus
Length: 1173  
Fragment?: false
•
•
•
•
•
Protein
Q05DK2
Organism: Mus musculus/domesticus
Length: 939  
Fragment?: true
•
•
•
•
•
Protein
Q05CJ7
Organism: Mus musculus/domesticus
Length: 936  
Fragment?: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom