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Search results 201 to 265 out of 265 for Asah1

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Type Details Score
Publication
29379059 | J:264488
First Author: Yu FPS
Year: 2018
Journal: Sci Rep
Title: Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.
Volume: 8
Issue: 1
Pages: 1808
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Publication
31835809 | J:289931
 
First Author: Beckmann N
Year: 2019
Journal: Int J Mol Sci
Title: Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.
Volume: 20
Issue: 24
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Publication
33139382 | J:323266
 
First Author: Becker KA
Year: 2021
Journal: Infect Immun
Title: Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections.
Volume: 89
Issue: 2
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Publication
23770692 | J:199833
First Author: Gulbins E
Year: 2013
Journal: Nat Med
Title: Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.
Volume: 19
Issue: 7
Pages: 934-8
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Publication
32817366 | J:310501
 
First Author: Alsamman S
Year: 2020
Journal: Sci Transl Med
Title: Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
Volume: 12
Issue: 557
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Publication
21487040 | J:170975
First Author: Hu X
Year: 2011
Journal: Cancer Res
Title: IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.
Volume: 71
Issue: 8
Pages: 2882-91
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Publication
18195024 | J:131574
First Author: Ventura CL
Year: 2008
Journal: Infect Immun
Title: Host airway proteins interact with Staphylococcus aureus during early pneumonia.
Volume: 76
Issue: 3
Pages: 888-98
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Publication
20211931 | J:162830
First Author: Xu YH
Year: 2010
Journal: J Lipid Res
Title: Multi-system disorders of glycosphingolipid and ganglioside metabolism.
Volume: 51
Issue: 7
Pages: 1643-75
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Publication
28552668 | J:272682
First Author: Grassmé H
Year: 2017
Journal: Cell Host Microbe
Title: β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections.
Volume: 21
Issue: 6
Pages: 707-718.e8
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Publication
23096701 | J:196477
First Author: Wang Z
Year: 2013
Journal: J Invest Dermatol
Title: Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.
Volume: 133
Issue: 3
Pages: 668-76
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Publication
29044125 | J:255485
First Author: Li S
Year: 2017
Journal: Sci Rep
Title: Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.
Volume: 7
Issue: 1
Pages: 13427
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Protein
Q9WV54
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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DO Term
DOID:0111527 | spinal muscular atrophy with progressive myoclonic epilepsy
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HT Experiment
E-GEOD-74463 | Altered lipid metabolism in the aging kidney identified by three layered omic analysis
Series Id: GSE74463
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
8203897 | -
First Author: Azuma N
Year: 1994
Journal: Arch Biochem Biophys
Title: Stimulation of acid ceramidase activity by saposin D.
Volume: 311
Issue: 2
Pages: 354-7
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Publication
18453694 | -
First Author: Popovic K
Year: 2008
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structures of the human ceramide activator protein saposin D.
Volume: 64
Issue: Pt 5
Pages: 589-94
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Publication
8955159 | -
First Author: Koch J
Year: 1996
Journal: J Biol Chem
Title: Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease.
Volume: 271
Issue: 51
Pages: 33110-5
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Publication
22703880 | -
First Author: Zhou J
Year: 2012
Journal: Am J Hum Genet
Title: Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.
Volume: 91
Issue: 1
Pages: 5-14
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Protein Domain
IPR016699 | Acid_ceramidase-like
Type: Family
Description: This group represents acid ceramidases and some related proteins of currently unknown function. Ceramide is hydrolyzed by both acid and alkaline ceramidase []. Acid ceramidase requires saposin D, a sphingolipid activator protein, for the lysosomal breakdown of ceramide to a fatty acid and sphingosine []. Ceramide is found in plasma membranes and plays a pivotal role in the metabolism of sphingolipids. In addition, ceramide and sphingosine may have important roles as second messengers for cell function and survival []. Mutations of the human acid ceramidase gene, ASAH1, cause Farber lipogranulomatosis (FRBRL), an autosomal recessive lysosomal storage disorder characterised by subcutaneous lipid-loaded nodules, excruciating pain in the joints and extremities, and marked accumulation of ceramide in lysosomes []. Mutations of ASAH1 also cause spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) [].
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Publication
29401619 | J:256650
   
First Author: Li F
Year: 2018
Journal: FASEB J
Title: Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates.
Pages: fj201700445RR
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Publication
30300671 | J:270213
First Author: Presa N
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
Volume: 1865
Issue: 1
Pages: 14-25
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Publication
36614115 | J:332612
 
First Author: Zhou X
Year: 2022
Journal: Int J Mol Sci
Title: iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes.
Volume: 24
Issue: 1
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Publication
28847804 | J:253020
First Author: Taguchi YV
Year: 2017
Journal: J Neurosci
Title: Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.
Volume: 37
Issue: 40
Pages: 9617-9631
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Publication
33352310 | J:316887
 
First Author: Chaurasia B
Year: 2021
Journal: Mol Metab
Title: Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.
Volume: 45
Pages: 101145
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Protein
Q9D7V9
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Protein
Q3U8A7
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q3U646
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q3TWT5
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q3V023
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Protein
G3XA18
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
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Protein
Q78P93
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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