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Search results 101 to 200 out of 663 for Tsc2

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Type Details Score
Publication
First Author: Simckes AM
Year: 2002
Journal: Cytogenet Genome Res
Title: Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome.
Volume: 97
Issue: 1-2
Pages: 111-5
Publication
First Author: Linke M
Year: 2017
Journal: Nat Immunol
Title: Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression.
Volume: 18
Issue: 3
Pages: 293-302
Publication
First Author: Kwiatkowski DJ
Year: 2002
Journal: Hum Mol Genet
Title: A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells.
Volume: 11
Issue: 5
Pages: 525-34
Publication
First Author: Tang G
Year: 2014
Journal: Neuron
Title: Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.
Volume: 83
Issue: 5
Pages: 1131-43
Publication
First Author: Yang F
Year: 2018
Journal: J Invest Dermatol
Title: Uncoupling of ER/Mitochondrial Oxidative Stress in mTORC1 Hyperactivation-Associated Skin Hypopigmentation.
Volume: 138
Issue: 3
Pages: 669-678
Publication
First Author: Yang F
Year: 2020
Journal: PLoS One
Title: Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model.
Volume: 15
Issue: 1
Pages: e0228204
Publication
First Author: Garami A
Year: 2003
Journal: Mol Cell
Title: Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Volume: 11
Issue: 6
Pages: 1457-66
Publication
First Author: Ebrahimi-Fakhari D
Year: 2016
Journal: Cell Rep
Title: Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex.
Volume: 17
Issue: 4
Pages: 1053-1070
Publication
First Author: Bartolomé A
Year: 2014
Journal: Diabetes
Title: Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.
Volume: 63
Issue: 9
Pages: 2996-3008
Publication
First Author: Sun Y
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis.
Volume: 51
Issue: 6
Pages: 738-49
Publication
First Author: Dibble CC
Year: 2012
Journal: Mol Cell
Title: TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Volume: 47
Issue: 4
Pages: 535-46
Publication
First Author: Bernardi R
Year: 2011
Journal: EMBO Mol Med
Title: Pml represses tumour progression through inhibition of mTOR.
Volume: 3
Issue: 5
Pages: 249-57
Publication
First Author: Olsson PG
Year: 1996
Journal: Genomics
Title: The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene.
Volume: 34
Issue: 2
Pages: 233-5
Publication
First Author: Kapfhamer D
Year: 2020
Journal: Hum Mol Genet
Title: Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.
Volume: 29
Issue: 14
Pages: 2395-2407
Publication  
First Author: Woodrum C
Year: 2010
Journal: J Transl Med
Title: Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors.
Volume: 8
Pages: 14
Publication
First Author: Lipton JO
Year: 2017
Journal: Cell Rep
Title: Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy.
Volume: 20
Issue: 4
Pages: 868-880
Publication
First Author: Wang F
Year: 2014
Journal: Oncogene
Title: Pivotal role of augmented αB-crystallin in tumor development induced by deficient TSC1/2 complex.
Volume: 33
Issue: 34
Pages: 4352-8
Publication  
First Author: Sugiura H
Year: 2015
Journal: Nat Commun
Title: Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.
Volume: 6
Pages: 6842
Publication
First Author: Ghosh HS
Year: 2010
Journal: PLoS One
Title: SIRT1 negatively regulates the mammalian target of rapamycin.
Volume: 5
Issue: 2
Pages: e9199
Publication
First Author: Ozcan U
Year: 2008
Journal: Mol Cell
Title: Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.
Volume: 29
Issue: 5
Pages: 541-51
Publication
First Author: Choi YJ
Year: 2008
Journal: Genes Dev
Title: Tuberous sclerosis complex proteins control axon formation.
Volume: 22
Issue: 18
Pages: 2485-95
Publication
First Author: Gilbert ER
Year: 2013
Journal: Am J Pathol
Title: Positioning ganglioside D3 as an immunotherapeutic target in lymphangioleiomyomatosis.
Volume: 183
Issue: 1
Pages: 226-34
Publication  
First Author: Sato A
Year: 2012
Journal: Nat Commun
Title: Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.
Volume: 3
Pages: 1292
Publication
First Author: Du H
Year: 2018
Journal: Hum Mol Genet
Title: A novel mouse model of hemangiopericytoma due to loss of Tsc2.
Volume: 27
Issue: 24
Pages: 4169-4175
Publication
First Author: Wang CY
Year: 2012
Journal: J Lipid Res
Title: Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis.
Volume: 53
Issue: 8
Pages: 1493-501
Publication
First Author: Lee L
Year: 2005
Journal: Genes Chromosomes Cancer
Title: Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models.
Volume: 42
Issue: 3
Pages: 213-27
Publication
First Author: Saré RM
Year: 2018
Journal: J Neurochem
Title: Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin.
Volume: 145
Issue: 5
Pages: 417-425
Publication
First Author: Kotani T
Year: 2020
Journal: Sci Rep
Title: Regulation of colonic epithelial cell homeostasis by mTORC1.
Volume: 10
Issue: 1
Pages: 13810
Publication
First Author: Habib SL
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Tuberin regulates the DNA repair enzyme OGG1.
Volume: 294
Issue: 1
Pages: F281-90
Publication
First Author: Medvetz D
Year: 2015
Journal: Mol Cancer Res
Title: Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift.
Volume: 13
Issue: 1
Pages: 3-8
Publication
First Author: Budanov AV
Year: 2008
Journal: Cell
Title: p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Volume: 134
Issue: 3
Pages: 451-60
Publication
First Author: Tavazoie SF
Year: 2005
Journal: Nat Neurosci
Title: Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2.
Volume: 8
Issue: 12
Pages: 1727-34
Publication
First Author: Huang Z
Year: 2022
Journal: Nat Commun
Title: mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.
Volume: 13
Issue: 1
Pages: 6915
Publication
First Author: Obraztsova K
Year: 2020
Journal: Nat Commun
Title: mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Volume: 11
Issue: 1
Pages: 5640
Publication
First Author: Burn TC
Year: 1996
Journal: Genome Res
Title: Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3.
Volume: 6
Issue: 6
Pages: 525-37
Publication
First Author: Abe N
Year: 2010
Journal: J Biol Chem
Title: Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.
Volume: 285
Issue: 36
Pages: 28034-43
Publication  
First Author: Short B
Year: 2019
Journal: Neurobiol Dis
Title: Cerebral aquaporin-4 expression is independent of seizures in tuberous sclerosis complex.
Volume: 129
Pages: 93-101
Publication
First Author: Jacobs BL
Year: 2017
Journal: J Biol Chem
Title: Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling.
Volume: 292
Issue: 17
Pages: 6987-6997
Publication
First Author: DeYoung MP
Year: 2008
Journal: Genes Dev
Title: Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.
Volume: 22
Issue: 2
Pages: 239-51
Publication  
First Author: Olsson PG
Year: 1996
Journal: Cytogenet Cell Genet
Title: A comparative clone map of the region containing the PKD1 gene in mouse
Volume: 72
Pages: 292 (Abstr.)
Publication
First Author: Short JD
Year: 2008
Journal: Cancer Res
Title: AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
Volume: 68
Issue: 16
Pages: 6496-506
Publication
First Author: Sasako T
Year: 2022
Journal: Nat Commun
Title: Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
Volume: 13
Issue: 1
Pages: 5655
Publication
First Author: Ehninger D
Year: 2008
Journal: Nat Med
Title: Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.
Volume: 14
Issue: 8
Pages: 843-8
Publication
First Author: Morales CR
Year: 2016
Journal: Sci Signal
Title: Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression.
Volume: 9
Issue: 422
Pages: ra34
Publication
First Author: Tripathi DN
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.
Volume: 110
Issue: 32
Pages: E2950-7
Publication
First Author: Bilanges B
Year: 2007
Journal: Mol Cell Biol
Title: Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.
Volume: 27
Issue: 16
Pages: 5746-64
Publication
First Author: Campos T
Year: 2016
Journal: Biochim Biophys Acta
Title: Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival.
Volume: 1863
Issue: 6 Pt A
Pages: 1200-7
Publication
First Author: Bonnet CS
Year: 2009
Journal: Hum Mol Genet
Title: Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis.
Volume: 18
Issue: 12
Pages: 2166-76
Publication
First Author: Beirowski B
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.
Volume: 114
Issue: 21
Pages: E4261-E4270
Publication
First Author: Uhlmann EJ
Year: 2002
Journal: Oncogene
Title: Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
Volume: 21
Issue: 25
Pages: 4050-9
Publication
First Author: Miyazaki M
Year: 2010
Journal: FEBS J
Title: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.
Volume: 277
Issue: 9
Pages: 2180-91
Publication
First Author: Mahjoub MR
Year: 2012
Journal: Curr Biol
Title: Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.
Volume: 22
Issue: 17
Pages: 1628-34
Publication
First Author: Mejia LA
Year: 2013
Journal: J Neurosci
Title: A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain.
Volume: 33
Issue: 46
Pages: 18015-21
Publication
First Author: Prizant H
Year: 2016
Journal: Endocr Relat Cancer
Title: Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model.
Volume: 23
Issue: 4
Pages: 265-80
Publication
First Author: Jaeschke A
Year: 2002
Journal: J Cell Biol
Title: Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.
Volume: 159
Issue: 2
Pages: 217-24
Publication
First Author: Moon UY
Year: 2015
Journal: Cell Rep
Title: Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.
Volume: 12
Issue: 6
Pages: 965-78
Publication
First Author: Magri L
Year: 2011
Journal: Cell Stem Cell
Title: Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.
Volume: 9
Issue: 5
Pages: 447-62
Publication
First Author: Tanwar PS
Year: 2014
Journal: Carcinogenesis
Title: Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.
Volume: 35
Issue: 3
Pages: 546-53
Publication
First Author: Jiang X
Year: 2008
Journal: Am J Pathol
Title: The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake.
Volume: 172
Issue: 6
Pages: 1748-56
Publication
First Author: Hartman TR
Year: 2009
Journal: Hum Mol Genet
Title: The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.
Volume: 18
Issue: 1
Pages: 151-63
Publication
First Author: Zhang H
Year: 2003
Journal: J Clin Invest
Title: Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.
Volume: 112
Issue: 8
Pages: 1223-33
Publication
First Author: Atochina-Vasserman EN
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Pharmacological targeting of VEGFR signaling with axitinib inhibits Tsc2-null lesion growth in the mouse model of lymphangioleiomyomatosis.
Volume: 309
Issue: 12
Pages: L1447-54
Publication
First Author: Patursky-Polischuk I
Year: 2009
Journal: Mol Cell Biol
Title: The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
Volume: 29
Issue: 3
Pages: 640-9
Publication
First Author: Crossland H
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway.
Volume: 305
Issue: 2
Pages: E183-93
Publication  
First Author: Miki Y
Year: 2018
Journal: Neurosci Lett
Title: Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging.
Volume: 684
Pages: 35-41
Publication
First Author: Tanwar PS
Year: 2012
Journal: Hum Mol Genet
Title: Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.
Volume: 21
Issue: 20
Pages: 4394-405
Publication
First Author: Terry BK
Year: 2022
Journal: Hum Mol Genet
Title: Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex.
Volume: 31
Issue: 12
Pages: 1979-1996
Publication
First Author: Han S
Year: 2012
Journal: J Biol Chem
Title: The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.
Volume: 287
Issue: 36
Pages: 30063-72
Publication
First Author: Zhang HH
Year: 2009
Journal: PLoS One
Title: Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
Volume: 4
Issue: 7
Pages: e6189
Publication
First Author: Magri L
Year: 2013
Journal: Dis Model Mech
Title: Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.
Volume: 6
Issue: 5
Pages: 1185-97
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kleymenova EV
Year: 1999
Journal: Genet Res
Title: Genetic variants of the tuberous sclerosis 2 tumour suppressor gene in mouse t haplotypes.
Volume: 74
Issue: 2
Pages: 139-44
Publication
First Author: Bozadjieva Kramer N
Year: 2021
Journal: Diabetes
Title: Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia.
Volume: 70
Issue: 2
Pages: 477-491
Publication
First Author: Liu HJ
Year: 2023
Journal: Nat Commun
Title: mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion.
Volume: 14
Issue: 1
Pages: 1214
Publication
First Author: Kelsey I
Year: 2017
Journal: Sci Rep
Title: mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci.
Volume: 7
Issue: 1
Pages: 16112
Publication
First Author: Obayashi Y
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration.
Volume: 437
Issue: 1
Pages: 146-50
Publication
First Author: Basu T
Year: 2019
Journal: Sci Rep
Title: Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex.
Volume: 9
Issue: 1
Pages: 5266
Publication
First Author: Lee G
Year: 2017
Journal: Cell
Title: Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.
Volume: 171
Issue: 7
Pages: 1545-1558.e18
Publication      
First Author: Saré RM
Year: 2022
Journal: eNeuro
Title: Confirmation of Decreased Rates of Cerebral Protein Synthesis In Vivo in a Mouse Model of Tuberous Sclerosis Complex.
Publication
First Author: Iwata W
Year: 2020
Journal: PLoS One
Title: Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure.
Volume: 15
Issue: 3
Pages: e0229397
Publication
First Author: Olsson PG
Year: 1995
Journal: Genomics
Title: The mouse homologue of the tuberin gene (TSC2) maps to a conserved synteny group between mouse chromosome 17 and human 16p13.3.
Volume: 25
Issue: 1
Pages: 339-40
Publication
First Author: Pilz A
Year: 1995
Journal: Genomics
Title: The mouse homologue of the human tuberous sclerosis 2 (TSC2) gene maps to chromosome 17, but does not fall within the tw18 or th20 deletions.
Volume: 26
Issue: 2
Pages: 420-1
Publication
First Author: Ben-Sahra I
Year: 2013
Journal: Science
Title: Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Volume: 339
Issue: 6125
Pages: 1323-8
Publication
First Author: Kovalenko A
Year: 2021
Journal: Cancer Res
Title: Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Volume: 81
Issue: 8
Pages: 2086-2100
GXD Expression      
Probe: MGI:2651514
Assay Type: Northern blot
Annotation Date: 2003-03-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:2651628
Age: embryonic day 12.0
Specimen Label: E12
Detected: true
Specimen Num: 1