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Search results 1 to 1 out of 1 for Tgs1

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
Type Details Score
Protein Domain
Type: Family
Description: Swm2 (Synthetic With MUD-2-delta protein2) binds Tgs1, an enzyme responsible for 2,2,7-trimethylguanosine (TMG) capping of small nuclear (sn) RNAs implicated in pre-mRNA splicing [, , ]. Deletion of SWM2 impairs pre-mRNA splicing and ribosome biogenesis, exhibiting a similar phenotype to tgs1 mutant. Swm2 is required for trimethylation of spliceosomal snRNAs and the U3 snoRNA by Tgs1 [].