Nance-Horan syndrome is an X-linked disorder characterised by congenital cataracts, dental anomalies, dysmorphic features, and, in some cases, mental retardation []. The syndrome is caused by defects in the NHS gene [], which appears to play a key role in the regulation of eye, tooth, brain, and craniofacial development []. It may function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipodia formation []. However, the protein's exact function is unknown.This entry represents the NHS protein family, which includes NHS protein and NHS-like proteins 1 and 2.