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Search results 1 to 100 out of 110 for Mast1

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Hits by Strain

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Type Details Score
Gene
22983 | MAST1
Type: gene
Organism: human
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Gene
456367 | MAST1
Type: gene
Organism: chimpanzee
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Gene
539825 | MAST1
Type: gene
Organism: cattle
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Gene
100682579 | MAST1
Type: gene
Organism: dog, domestic
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Gene
717903 | MAST1
Type: gene
Organism: macaque, rhesus
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Gene
100497439 | mast1
Type: gene
Organism: frog, western clawed
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Gene
353118 | MAST1
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1861901 | Mast1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028777 | MAST1
Type: Family
Description: Microtubule-associated serine/threonine-protein kinase 1 (MAST1) belongs to the MAST family, which is characterised by containing a serine/threonine kinase domain and a PDZ (postsynaptic density protein-95/discs large/zona occludens-1) domain []. It links the dystrophin/utrophin network with microtubule filaments via the syntrophins []. MAST1 localises in the DAPC/UAPC, which is found within the postsynaptic region of the neuromuscular junction (NMJ) and central synapses []. The splice variant of its C-terminal affects its subcellular localisation within neurons []. Mutations in this protein cause mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations (MCC-CH-CM) but they were also found in patients with autism and microcephaly, suggesting that MAST1 alterations are involved in a wide spectrum of neurodevelopmental diseases [].
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Publication
30449657 | J:268904
First Author: Tripathy R
Year: 2018
Journal: Neuron
Title: Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.
Volume: 100
Issue: 6
Pages: 1354-1368.e5
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Publication
10404183 | J:63891
First Author: Lumeng C
Year: 1999
Journal: Nat Neurosci
Title: Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases.
Volume: 2
Issue: 7
Pages: 611-7
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Publication
12614677 | -
First Author: Yano R
Year: 2003
Journal: Neuroscience
Title: Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions.
Volume: 117
Issue: 2
Pages: 373-81
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Publication
18206861 | -
 
First Author: Garland P
Year: 2008
Journal: Brain Res
Title: Expression of the MAST family of serine/threonine kinases.
Volume: 1195
Pages: 12-9
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Protein
Q7TQ97
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: true
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Protein
Q3URY8
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: false
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Protein
E9Q6Q5
Organism: Mus musculus/domesticus
Length: 658  
Fragment?: false
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Protein
Q9R1L5
Organism: Mus musculus/domesticus
Length: 1570  
Fragment?: false
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Publication
15951562 | J:114725
First Author: Valiente M
Year: 2005
Journal: J Biol Chem
Title: Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.
Volume: 280
Issue: 32
Pages: 28936-43
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Protein Coding Gene
MGP_CAROLIEiJ_G0031317 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033880 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033856 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033566 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1861901 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034376 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032896 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033695 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033643 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034393 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033009 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022922 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032436 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Male
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3586121
Age: postnatal adult
Image: Adult
Specimen Label: Adult
Detected: false
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915526
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:3586121
Age: embryonic day 18.0
Image: E18
Note: Expression was detected in a subset of cells in the inner neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3586121
Age: postnatal day 0-1
Image: P0/1
Note: Expression was detected in the scleral inner neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915527
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:3586121
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the scleral inner neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3586121
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the scleral inner neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586121
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586121
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3586121
Age: embryonic day 16.0
Specimen Label: Embryo
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586121
Age: postnatal day 6
Note: Expression was widespread.
Specimen Label: CNS
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586121
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586121
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3586121
Age: embryonic day 16.0
Image: E16
Note: Expression was detected in the inner neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1646924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3586121
Age: embryonic day 16.0
Specimen Label: Embryo
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3586121
Age: postnatal day 6-7
Image: P6/7
Note: Expression was detected in amacrine cells.
Specimen Label: P6/7
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3586121
Age: postnatal day 8-10
Image: P8/10
Note: Expression was detected in amacrine cells.
Specimen Label: P8/10
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3584907
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3586121
Age: embryonic day 14.0
Note: Expression was detected in the inner neuroblastic layer.
Specimen Label: E14
Detected: true
Specimen Num: 1
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Publication
10903447 | J:63631
First Author: Krieser RJ
Year: 2000
Journal: Gene
Title: Deoxyribonuclease II: structure and chromosomal localization of the murine gene, and comparison with the genomic structure of the human and three C. elegans homologs.
Volume: 252
Issue: 1-2
Pages: 155-62
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Publication
20654717 | J:171316
First Author: Sasaki N
Year: 2010
Journal: Mol Cell Neurosci
Title: Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation.
Volume: 45
Issue: 4
Pages: 335-44
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Publication
33220177 | J:300487
First Author: Chai G
Year: 2021
Journal: Neuron
Title: Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.
Volume: 109
Issue: 2
Pages: 241-256.e9
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Publication
12477932 | J:82808
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Mast1<em2Dak> | MGI:6356293
Name: microtubule associated serine/threonine kinase 1; endonuclease-mediated mutation 2, David A Keays
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mast1<em1Dak> | MGI:6356292
Name: microtubule associated serine/threonine kinase 1; endonuclease-mediated mutation 1, David A Keays
Allele Type: Endonuclease-mediated
Attribute String: Dominant negative
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Genotype
Genotype
Symbol: Mast1/Mast1<+>
Background: B6.Cg-Mast1
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0111403 | mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations
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Publication
16159897 | -
First Author: Wang D
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Coexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3.
Volume: 290
Issue: 2
Pages: F428-37
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Protein Domain
IPR037711 | MAST
Type: Domain
Description: MAST (Microtubule-Associated Serine/Threonine) kinases are characterised by containing a serine/threonine kinase domain and a PDZ (postsynaptic density protein-95/discs large/zona occludens-1) domain []. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN []. MAST1 links the dystrophin/utrophin network with microtubule filaments via the syntrophins []. MAST1 localises in the DAPC/UAPC, which is found within the postsynaptic region of the neuromuscular junction (NMJ) and central synapses []. The splice variant of its C-terminal affects its subcellular localisation within neurons []. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3 [].
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Publication
34185323 | J:333007
First Author: Spinelli E
Year: 2021
Journal: Ann Neurol
Title: Pathogenic MAST3 Variants in the STK Domain Are Associated with Epilepsy.
Volume: 90
Issue: 2
Pages: 274-284
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Protein
E9Q6G0
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: true
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Protein
Q60592
Organism: Mus musculus/domesticus
Length: 1734  
Fragment?: false
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Protein
Q3U214
Organism: Mus musculus/domesticus
Length: 1321  
Fragment?: false
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Protein
B1AST7
Organism: Mus musculus/domesticus
Length: 1739  
Fragment?: false
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Protein
A0A668KLF8
Organism: Mus musculus/domesticus
Length: 1642  
Fragment?: false
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•
Protein
A0A1D5RM97
Organism: Mus musculus/domesticus
Length: 1305  
Fragment?: false
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•
•
•
•
Protein
B1AST8
Organism: Mus musculus/domesticus
Length: 1733  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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