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Search results 401 to 474 out of 474 for Car13

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0.021s
Type Details Score
GXD Expression  
Probe: MGI:7595859
Assay Type: RNA in situ
Annotation Date: 2024-02-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3579928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7596320
Age: postnatal day 5
Image: 3L
Specimen Label: 3L
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7595859
Assay Type: RNA in situ
Annotation Date: 2024-02-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3579928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7596320
Age: postnatal day 21
Specimen Label: not shown
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3725037
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5421687
Age: embryonic day 14.5
Specimen Label: MH2292; Specimen C2572
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3725037
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5421687
Age: embryonic day 14.5
Specimen Label: MH2292; Specimen C2572
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3725037
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5421687
Age: embryonic day 14.5
Specimen Label: MH2292; Specimen C2572
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3725037
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421687
Age: embryonic day 14.5
Specimen Label: MH2292; Specimen C2572
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3725037
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5421687
Age: embryonic day 14.5
Specimen Label: MH2292; Specimen C2572
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3725037
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421687
Age: embryonic day 14.5
Specimen Label: MH2292; Specimen C2572
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_03
Specimen Label: euxassay_006767_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_04
Specimen Label: euxassay_006767_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_05
Specimen Label: euxassay_006767_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_06
Specimen Label: euxassay_006767_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_07
Specimen Label: euxassay_006767_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_08
Specimen Label: euxassay_006767_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_09
Specimen Label: euxassay_006767_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_10
Specimen Label: euxassay_006767_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_11
Specimen Label: euxassay_006767_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_12
Specimen Label: euxassay_006767_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_13
Specimen Label: euxassay_006767_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_14
Specimen Label: euxassay_006767_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_15
Specimen Label: euxassay_006767_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_16
Specimen Label: euxassay_006767_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_17
Specimen Label: euxassay_006767_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_18
Specimen Label: euxassay_006767_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_19
Specimen Label: euxassay_006767_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_20
Specimen Label: euxassay_006767_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_21
Specimen Label: euxassay_006767_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1779123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_22
Specimen Label: euxassay_006767_22
Detected: true
Specimen Num: 22
GXD Expression
Probe: MGI:7595859
Assay Type: RNA in situ
Annotation Date: 2024-02-23
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3288723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7596320
Age: embryonic day 15.5
Image: 3J
Note: Weak expression was observed in the vestibule mesenchymal tissues along the otic capsule.
Specimen Label: 3J
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_07
Specimen Label: euxassay_006767_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_08
Specimen Label: euxassay_006767_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_09
Specimen Label: euxassay_006767_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_10
Specimen Label: euxassay_006767_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_11
Specimen Label: euxassay_006767_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_13
Specimen Label: euxassay_006767_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_14
Specimen Label: euxassay_006767_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_16
Specimen Label: euxassay_006767_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_17
Specimen Label: euxassay_006767_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_18
Specimen Label: euxassay_006767_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_19
Specimen Label: euxassay_006767_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_20
Specimen Label: euxassay_006767_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_21
Specimen Label: euxassay_006767_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_22
Specimen Label: euxassay_006767_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823628
Age: embryonic day 14.5
Image: euxassay_006767_23
Specimen Label: euxassay_006767_23
Detected: true
Specimen Num: 23
GXD Expression    
Probe: MGI:3725037
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421687
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH2292; Specimen C2572
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2826626
Stage: TS26
Assay Id: MGI:5538772
Age: embryonic day 17.5
Image: GUDMAP:14810
Specimen Label: GUDMAP:14810
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2826628
Stage: TS28
Assay Id: MGI:5538772
Age: postnatal day 84
Image: GUDMAP:14811
Specimen Label: GUDMAP:14811
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:546361
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2772126
Stage: TS26
Assay Id: MGI:5538772
Age: embryonic day 17.5
Image: GUDMAP:14810
Specimen Label: GUDMAP:14810
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3725037
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5421687
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MH2292; Specimen C2572
Detected: false
Specimen Num: 1
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication    
First Author: Hewett-Emmett D
Year: 2001
Journal: GenBank Submission
Title: Mus musculus carbonic anhydrase XIII (Car13) mRNA, complete cds
Pages: AF231123
Protein
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
Allele
Name: carbonic anhydrase 3; targeted mutation 1, Geumsoo Kim
Allele Type: Targeted
Attribute String: Null/knockout
Strain
Attribute String: targeted mutation, mutant strain
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Publication
First Author: Kim G
Year: 2004
Journal: Mol Cell Biol
Title: Carbonic anhydrase III is not required in the mouse for normal growth, development, and life span.
Volume: 24
Issue: 22
Pages: 9942-7
Publication
First Author: Renner SW
Year: 2017
Journal: PLoS One
Title: Carbonic anhydrase III (Car3) is not required for fatty acid synthesis and does not protect against high-fat diet induced obesity in mice.
Volume: 12
Issue: 4
Pages: e0176502
Publication
First Author: Mitterberger MC
Year: 2012
Journal: Exp Cell Res
Title: Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-γ2.
Volume: 318
Issue: 8
Pages: 877-86
Publication
First Author: Liu M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A quantitative study of bioenergetics in skeletal muscle lacking carbonic anhydrase III using 31P magnetic resonance spectroscopy.
Volume: 104
Issue: 1
Pages: 371-6
Genotype
Symbol: Car3/Car3
Background: involves: 129S/SvEv * 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Pan P
Year: 2006
Journal: J Physiol
Title: Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice.
Volume: 571
Issue: Pt 2
Pages: 319-27
Publication
First Author: Gailly P
Year: 2008
Journal: Kidney Int
Title: A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction.
Volume: 74
Issue: 1
Pages: 52-61