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Search results 1 to 100 out of 107 for Fmo1

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
2326 | FMO1
Type: gene
Organism: human
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Gene
456444 | FMO1
Type: gene
Organism: chimpanzee
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Gene
508781 | FMO1
Type: gene
Organism: cattle
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Gene
703743 | FMO1
Type: gene
Organism: macaque, rhesus
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Gene
549120 | fmo1
Type: gene
Organism: frog, western clawed
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Gene
key_31311 | FMO1
Type: gene
Organism: rabbit, European
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Gene
25256 | Fmo1
Type: gene
Organism: rat
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Gene
403604 | FMO1
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1310002 | Fmo1
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1897623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5448197
Age: embryonic day 15.5
Image: 3B Fmo1
Note: Expression was detected in the proximal convoluted tubules.
Specimen Label: 3B Fmo1
Detected: true
Specimen Num: 1
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Publication
24792439 | J:214341
First Author: Veeravalli S
Year: 2014
Journal: Biochem Pharmacol
Title: The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
Volume: 90
Issue: 1
Pages: 88-95
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Publication
19262426 | J:196270
First Author: Hernandez D
Year: 2009
Journal: Pharmacogenet Genomics
Title: Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.
Volume: 19
Issue: 4
Pages: 289-99
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GXD Expression
GXD Expression
   
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190291
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fmo1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190291
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fmo1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190291
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fmo1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190291
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fmo1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190291
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fmo1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190291
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fmo1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190291
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fmo1
Detected: true
Specimen Num: 7
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Publication
32156684 | J:328499
First Author: Veeravalli S
Year: 2020
Journal: Drug Metab Dispos
Title: Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.
Volume: 48
Issue: 5
Pages: 378-385
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Publication
9076656 | J:40884
First Author: Itoh K
Year: 1997
Journal: J Toxicol Sci
Title: Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ).
Volume: 22
Issue: 1
Pages: 45-56
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Publication
34500002 | J:312983
 
First Author: Li B
Year: 2021
Journal: Neurosci Lett
Title: Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice.
Volume: 764
Pages: 136222
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Publication
9580872 | J:48888
First Author: Cherrington NJ
Year: 1998
Journal: J Biochem Mol Toxicol
Title: Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5).
Volume: 12
Issue: 4
Pages: 205-12
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Publication
7473608 | J:28615
First Author: Falls JG
Year: 1995
Journal: J Biochem Toxicol
Title: Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice.
Volume: 10
Issue: 3
Pages: 171-7
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Publication
9186481 | J:40799
First Author: Falls JG
Year: 1997
Journal: Arch Biochem Biophys
Title: Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids.
Volume: 342
Issue: 2
Pages: 212-23
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Protein Coding Gene
MGP_CAROLIEiJ_G0014777 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016665 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016646 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016612 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016607 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016431 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1310002 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017068 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016011 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016406 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016583 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015797 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016073 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028014 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015584 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Specimen Label: GUDMAP:9620
Detected: false
Specimen Num: 1
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Publication
29168693 | J:254969
   
First Author: Huang X
Year: 2017
Journal: Elife
Title: Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling.
Volume: 6
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Publication
18346943 | J:133949
First Author: Valerius MT
Year: 2008
Journal: Gene Expr Patterns
Title: Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation.
Volume: 8
Issue: 5
Pages: 297-306
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Publication
15760467 | J:99477
 
First Author: Brown AC
Year: 2005
Journal: BMC Genet
Title: Searching QTL by gene expression: analysis of diabesity.
Volume: 6
Pages: 12
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Del(1Fmo4-Fmo2)1Eshe | MGI:5487815
Name: deletion, Chr 1, Elizabeth A Shephard 1
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:5488501 | B6.129P2-Del(1Fmo4-Fmo2)1Eshe
Attribute String: congenic, mutant strain, deletion
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Genotype
Genotype
Symbol: Del(1Fmo4-Fmo2)1Eshe/+
Background: B6.129P2-Del(1Fmo4-Fmo2)1Eshe
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(1Fmo4-Fmo2)1Eshe/Del(1Fmo4-Fmo2)1Eshe
Background: B6.129P2-Del(1Fmo4-Fmo2)1Eshe
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:0004499 | N,N-dimethylaniline monooxygenase activity
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Publication
29070510 | J:278567
First Author: Veeravalli S
Year: 2018
Journal: Drug Metab Dispos
Title: Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis.
Volume: 46
Issue: 1
Pages: 20-25
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Publication
8311461 | J:16633
First Author: Lawton MP
Year: 1994
Journal: Arch Biochem Biophys
Title: A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.
Volume: 308
Issue: 1
Pages: 254-7
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Publication
23312283 | J:195072
First Author: Bennett BJ
Year: 2013
Journal: Cell Metab
Title: Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Volume: 17
Issue: 1
Pages: 49-60
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Protein Domain
IPR002253 | Flavin_mOase_1
Type: Family
Description: Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes []. Using an NADPH cofactor and FAD prosthetic group, these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorous and selenium atoms in a range of structurally diverse compounds. FMOs have been implicated in the metabolism of a number of pharmaceuticals, pesticides and toxicants. In man, lack of hepatic FMO-catalysed trimethylamine metabolism results in trimethylaminuria (fish odour syndrome). Five mammalian forms of FMO are now known and have been designated FMO1-FMO5 [, , , , ].Human FMO1 mRNA is more abundant in foetal than in adult liver, indicating that the enzyme is subject to developmental regulation in man []. The deduced amino sequence contains putative FAD- (GxGxxG) and NADP+-binding (GxGxxA) sites, a 'FATGY' motif that has also been observed in a range of siderphore biosynthetic enzymes [], and a C-terminal hydrophobic segment that is believed to anchor the monooxygenase to the microsomal membrane []. The human sequence shares 88 and 86% identity, respectively, with pig and rabbit 'hepatic' forms of FMO, but is only 58% similar to the abbit 'pulmonary' FMO [].
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Protein
P50285
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q3UK74
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
Q3UNX7
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
D3Z0T2
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
G3X946
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
A0A0A6YVP9
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
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