Proteins containing this domain include aarF domain containing kinase 2 (ADCK2) from humans, YPL109C from budding yeasts and SPBC21C3.03 from fission yeasts. Eukaryotes contain at least three ABC1-like proteins; in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2 [, ]. YPL109C and SPBC21C3.03 are uncharacterised mitochondrial proteins.
This entry represents a domain found in AarF domain containing kinase 1 (ADCK1) and related proteins. Drosophila ADCK1 plays an important role in maintaining mitochondrial morphologies and functions in the muscle []. Proteins containing this domain also include Mcp2, which is a component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression []. It is also involved in mitochondrial lipid homeostasis [].