Type |
Details |
Score |
Allele |
Name: |
DNA methyltransferase 3B; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Publication |
First Author: |
Dunican DS |
Year: |
2013 |
Journal: |
Genome Biol |
Title: |
Lsh regulates LTR retrotransposon repression independently of Dnmt3b function. |
Volume: |
14 |
Issue: |
12 |
Pages: |
R146 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3525854 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-03-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3148228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3528428 |
Age: |
postnatal adult |
Image: |
5L |
Note: |
Dnmt3a and Dnmt3b were not significantly expressed in the same spermatogonia. |
Specimen Label: |
5L |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3525854 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2005-03-07 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684619 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:3528428 |
Age: |
embryonic day 11.5 |
Image: |
2F |
Note: |
The cells expressing Dnmt3b did not express a significant amount of Dnmt3a, and vice versa. |
Specimen Label: |
2F |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeshima H |
Year: |
2006 |
Journal: |
J Biochem |
Title: |
Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA. |
Volume: |
139 |
Issue: |
3 |
Pages: |
503-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin B |
Year: |
1999 |
Journal: |
Zhongguo Yi Xue Ke Xue Yuan Xue Bao |
Title: |
[Cloning of full-length Dnmt3b cDNA and its alternative splicing isoforms in mouse embryo]. |
Volume: |
21 |
Issue: |
6 |
Pages: |
431-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suetake I |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction. |
Volume: |
279 |
Issue: |
26 |
Pages: |
27816-23 |
|
•
•
•
•
•
|
Allele |
Name: |
DNA methyltransferase 3B; targeted mutation 7, En Li |
Allele Type: |
Targeted |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
Allele |
Name: |
DNA methyltransferase 3B; targeted mutation 1, En Li |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
DNA methyltransferase 3B; targeted mutation 6, En Li |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Hypomorph |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Allu PK |
Year: |
2019 |
Journal: |
Curr Biol |
Title: |
Structure of the Human Core Centromeric Nucleosome Complex. |
Volume: |
29 |
Issue: |
16 |
Pages: |
2625-2639.e5 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability. This entry represents the middle DNMT3B binding region of CENP-C. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats. CENP-C and DNMT3B regulate the histone code in these regions [, , ]. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dnmt3b/Dnmt3b |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dnmt3a/Dnmt3a Dnmt3b/Dnmt3b |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dnmt3b/Dnmt3b |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dnmt3b/Dnmt3b |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dnmt3b/Dnmt3b |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dnmt3b/Dnmt3b |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dnmt3b/Dnmt3b |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamaguchi R |
Year: |
2012 |
Journal: |
Mol Biol Cell |
Title: |
Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa. |
Volume: |
23 |
Issue: |
14 |
Pages: |
2671-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
350
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
189
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
350
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents protein MENT (methylated in normal thymocytes protein), which is involved in control of cellular proliferation. It is an onconcogenic modifier contributing to the tumour suppressor function of DNMT3B (DNA methyltransferase 3B) []. This entry also includes the mouse Pmis1 protein that may regulate sperm transport into the oviducts and function in modulating sperm-zona binding []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ]. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
522
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
446
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Cohen RL |
Year: |
2008 |
Journal: |
Mol Biol Cell |
Title: |
Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein. |
Volume: |
19 |
Issue: |
10 |
Pages: |
4480-91 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the ADD domain of DNMT3B. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. Many DNMT3B isoforms from alternative splicing have been described, among which DNMT3B3 stimulates the basal activity of DNMT3 enzymes, but partially inhibits the stimulatory effect of DNMT3L, whereas DNMT3B4 significantly impairs de novo methylation [, ]. DNMT3B is involved in development and is associated with several diseases, including cancers []. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma S |
Year: |
2011 |
Journal: |
PLoS Genet |
Title: |
Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. |
Volume: |
7 |
Issue: |
2 |
Pages: |
e1001286 |
|
•
•
•
•
•
|
Publication |
First Author: |
Makar AB |
Year: |
1975 |
Journal: |
Biochem Med |
Title: |
Formate assay in body fluids: application in methanol poisoning. |
Volume: |
13 |
Issue: |
2 |
Pages: |
117-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bose KS |
Year: |
1975 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution. |
Volume: |
66 |
Issue: |
4 |
Pages: |
1173-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayle A |
Year: |
2015 |
Journal: |
Blood |
Title: |
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. |
Volume: |
125 |
Issue: |
4 |
Pages: |
629-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Celik H |
Year: |
2015 |
Journal: |
Blood |
Title: |
Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation. |
Volume: |
125 |
Issue: |
4 |
Pages: |
619-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo X |
Year: |
2015 |
Journal: |
Nature |
Title: |
Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. |
Volume: |
517 |
Issue: |
7536 |
Pages: |
640-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos GC Jr |
Year: |
2015 |
Journal: |
J Cell Biochem |
Title: |
Epigenetic modifications, chromatin distribution and TP53 transcription in a model of breast cancer progression. |
Volume: |
116 |
Issue: |
4 |
Pages: |
533-41 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ].This entry represents the ADDz domain found in DNA (cytosine-5)-methyltransferase 3A (DNMT3A). The ADD domain is composed of three clearly distinguishable modules that pack together through extensive hydrophobic interactions to form a single globular domain. Packed against this GATA-like finger is a second subdomain, which binds two zinc ions and closely resembles the structure reported for several PHD fingers. Finally, there is a long C-terminal α-helix that runs out from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain close together. This combination of fused GATA-like and PHD fingers within a single domain is thus far unique [, ].The ADD domains of the DNMT3 family have a decisive role in blocking DNMT activity in the areas of the genome with chromatin containing methylated H3K4. Furthermore, the ADD domain of DNMMT3A (ADD-3A) competes with the chromodomain (CD) of heterochromatin protein 1 alpha (HP1alpha, CDHP1alpha) for binding to the H3 tail. The DNA methyltransferase (DNMT) 3 family members DNMT3A and DNMT3B and the DNMT3-like non-enzymatic regulatory factor DNMT3L, are involved in de-novo establishment of DNA methylation patterns in early mammalian development [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Otani J |
Year: |
2009 |
Journal: |
EMBO Rep |
Title: |
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1235-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo Y |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection. |
Volume: |
13 |
|
Pages: |
942465 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
906
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Argentaro A |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX. |
Volume: |
104 |
Issue: |
29 |
Pages: |
11939-44 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE76261 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Roberts AR |
Year: |
2011 |
Journal: |
Chromosoma |
Title: |
Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo. |
Volume: |
120 |
Issue: |
4 |
Pages: |
377-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei G |
Year: |
2020 |
Journal: |
iScience |
Title: |
The PWWP2A Histone Deacetylase Complex Represses Intragenic Spurious Transcription Initiation in mESCs. |
Volume: |
23 |
Issue: |
11 |
Pages: |
101741 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aapola U |
Year: |
2000 |
Journal: |
Genomics |
Title: |
Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. |
Volume: |
65 |
Issue: |
3 |
Pages: |
293-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanna CW |
Year: |
2018 |
Journal: |
Nat Struct Mol Biol |
Title: |
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes. |
Volume: |
25 |
Issue: |
1 |
Pages: |
73-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao Q |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression. |
Volume: |
108 |
Issue: |
44 |
Pages: |
18061-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Challen GA |
Year: |
2011 |
Journal: |
Nat Genet |
Title: |
Dnmt3a is essential for hematopoietic stem cell differentiation. |
Volume: |
44 |
Issue: |
1 |
Pages: |
23-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Hagan HM |
Year: |
2011 |
Journal: |
Cancer Cell |
Title: |
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. |
Volume: |
20 |
Issue: |
5 |
Pages: |
606-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sado T |
Year: |
2004 |
Journal: |
Development |
Title: |
De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation. |
Volume: |
131 |
Issue: |
5 |
Pages: |
975-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mishra A |
Year: |
2012 |
Journal: |
Cancer Cell |
Title: |
Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. |
Volume: |
22 |
Issue: |
5 |
Pages: |
645-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dan J |
Year: |
2013 |
Journal: |
Sci Rep |
Title: |
Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells. |
Volume: |
3 |
|
Pages: |
3492 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang J |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs. |
Volume: |
15 |
Issue: |
8 |
Pages: |
1809-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sendžikaitė G |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
1884 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kinoshita M |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory. |
Volume: |
118 |
Issue: |
38 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
332
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
202
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
184
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
140
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, AD-DATRX) found in DNMT3A proteins. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].The ADD domains of the DNMT3 family have a decisive role in blocking DNMT activity in the areas of the genome with chromatin containing methylated H3K4. Furthermore, the ADD domain of DNMMT3A (ADD-3A) competes with the chromodomain (CD) of heterochromatin protein 1 alpha (HP1alpha, CDHP1alpha) for binding to the H3 tail. The DNA methyltransferase (DNMT) 3 family members DNMT3A and DNMT3B and the DNMT3-like non-enzymatic regulatory factor DNMT3L, are involved in de-novo establishment of DNA methylation patterns in early mammalian development [, ]. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Jain D |
Year: |
2017 |
Journal: |
PLoS Genet |
Title: |
rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. |
Volume: |
13 |
Issue: |
8 |
Pages: |
e1006964 |
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Publication |
First Author: |
Peters SL |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. |
Volume: |
33 |
Issue: |
21 |
Pages: |
4321-33 |
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Publication |
First Author: |
Veeranki S |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications. |
Volume: |
1852 |
Issue: |
5 |
Pages: |
732-41 |
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Publication |
First Author: |
Gowher H |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. |
Volume: |
109 |
Issue: |
7 |
Pages: |
2370-5 |
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Publication |
First Author: |
Li C |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation. |
Volume: |
288 |
Issue: |
26 |
Pages: |
19127-39 |
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Publication |
First Author: |
Yamaguchi S |
Year: |
2013 |
Journal: |
Nature |
Title: |
Role of Tet1 in erasure of genomic imprinting. |
Volume: |
504 |
Issue: |
7480 |
Pages: |
460-4 |
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Publication |
First Author: |
Dai HQ |
Year: |
2016 |
Journal: |
Nature |
Title: |
TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. |
Volume: |
538 |
Issue: |
7626 |
Pages: |
528-532 |
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Publication |
First Author: |
Shirakawa T |
Year: |
2013 |
Journal: |
Development |
Title: |
An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity. |
Volume: |
140 |
Issue: |
17 |
Pages: |
3565-76 |
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Publication |
First Author: |
Yan C |
Year: |
2016 |
Journal: |
Diabetologia |
Title: |
A decrease in hepatic microRNA-9 expression impairs gluconeogenesis by targeting FOXO1 in obese mice. |
Volume: |
59 |
Issue: |
7 |
Pages: |
1524-1532 |
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Publication |
First Author: |
Schemmer J |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e71113 |
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Publication |
First Author: |
Huang Y |
Year: |
2012 |
Journal: |
J Nutr |
Title: |
A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. |
Volume: |
142 |
Issue: |
5 |
Pages: |
818-23 |
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Publication |
First Author: |
Morey SR |
Year: |
2006 |
Journal: |
Cancer Res |
Title: |
DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. |
Volume: |
66 |
Issue: |
24 |
Pages: |
11659-67 |
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Publication |
First Author: |
Domingo-Gonzalez R |
Year: |
2015 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation. |
Volume: |
308 |
Issue: |
1 |
Pages: |
L86-95 |
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Publication |
First Author: |
Datta J |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. |
Volume: |
65 |
Issue: |
23 |
Pages: |
10891-900 |
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Publication |
First Author: |
Juriloff DM |
Year: |
2000 |
Journal: |
Hum Mol Genet |
Title: |
Mouse models for neural tube closure defects. |
Volume: |
9 |
Issue: |
6 |
Pages: |
993-1000 |
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Publication |
First Author: |
Robertson KD |
Year: |
1999 |
Journal: |
Nucleic Acids Res |
Title: |
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. |
Volume: |
27 |
Issue: |
11 |
Pages: |
2291-8 |
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Publication |
First Author: |
Xie S |
Year: |
1999 |
Journal: |
Gene |
Title: |
Cloning, expression and chromosome locations of the human DNMT3 gene family. |
Volume: |
236 |
Issue: |
1 |
Pages: |
87-95 |
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Publication |
First Author: |
Weisenberger DJ |
Year: |
2002 |
Journal: |
Gene |
Title: |
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. |
Volume: |
298 |
Issue: |
1 |
Pages: |
91-9 |
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Publication |
First Author: |
Lees-Murdock DJ |
Year: |
2004 |
Journal: |
Genomics |
Title: |
Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. |
Volume: |
84 |
Issue: |
1 |
Pages: |
193-204 |
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Publication |
First Author: |
Li H |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells. |
Volume: |
281 |
Issue: |
28 |
Pages: |
19489-500 |
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Publication |
First Author: |
Nimura K |
Year: |
2006 |
Journal: |
Genes Cells |
Title: |
Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation. |
Volume: |
11 |
Issue: |
10 |
Pages: |
1225-37 |
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Publication |
First Author: |
Fan T |
Year: |
2008 |
Journal: |
Epigenetics |
Title: |
DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development. |
Volume: |
3 |
Issue: |
3 |
Pages: |
134-42 |
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Publication |
First Author: |
Fang X |
Year: |
2016 |
Journal: |
FASEB J |
Title: |
Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes. |
Volume: |
30 |
Issue: |
9 |
Pages: |
3238-55 |
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Publication |
First Author: |
Tovy A |
Year: |
2017 |
Journal: |
Genes Dev |
Title: |
p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity. |
Volume: |
31 |
Issue: |
10 |
Pages: |
959-972 |
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Publication |
First Author: |
Termanis A |
Year: |
2016 |
Journal: |
Nucleic Acids Res |
Title: |
The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells. |
Volume: |
44 |
Issue: |
16 |
Pages: |
7592-604 |
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Publication |
First Author: |
Luo G |
Year: |
2019 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B. |
Volume: |
60 |
Issue: |
2 |
Pages: |
650-660 |
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