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Search results 401 to 500 out of 578 for Icos

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Hits by Pathway

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Hits by Category

Type Details Score
Strain
MGI:6354869 | C57BL/6J-Icosl<em2(ICOSLG)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:2682594 | B6.129P2-Icosl<tm1Mak>/J
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Icosl/Icosl
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
20574047 | J:164496
First Author: Fukaya T
Year: 2010
Journal: Blood
Title: Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Volume: 116
Issue: 13
Pages: 2266-76
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Strain
MGI:6354867 | C57BL/6J-Icos<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Icos<em2(ICOS)Smoc> | MGI:7290298
Name: inducible T cell co-stimulator; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
11283156 | J:68616
First Author: Tseng SY
Year: 2001
Journal: J Exp Med
Title: B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
Volume: 193
Issue: 7
Pages: 839-46
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Publication
25552357 | J:234140
First Author: Clement M
Year: 2015
Journal: Circulation
Title: Control of the T follicular helper-germinal center B-cell axis by CD8⁺ regulatory T cells limits atherosclerosis and tertiary lymphoid organ development.
Volume: 131
Issue: 6
Pages: 560-70
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Strain
MGI:6354866 | C57BL/6J-Icos<em2(ICOS)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Icos<em1Smoc> | MGI:7290297
Name: inducible T cell co-stimulator; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
11015443 | J:64991
First Author: Freeman GJ
Year: 2000
Journal: J Exp Med
Title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Volume: 192
Issue: 7
Pages: 1027-34
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Publication
11036763 | J:68971
 
First Author: Aurrand-Lions MA
Year: 2000
Journal: Curr Top Microbiol Immunol
Title: Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?
Volume: 251
Pages: 91-8
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Publication
21768353 | J:176027
First Author: Hu H
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development.
Volume: 108
Issue: 31
Pages: 12827-32
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Publication
20639877 | J:162534
First Author: Glasmacher E
Year: 2010
Journal: Nat Immunol
Title: Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.
Volume: 11
Issue: 8
Pages: 725-33
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Publication
25002484 | J:212264
First Author: Xin L
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2.
Volume: 111
Issue: 29
Pages: 10672-7
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Publication
23583642 | J:196137
First Author: Pratama A
Year: 2013
Journal: Immunity
Title: Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.
Volume: 38
Issue: 4
Pages: 669-80
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Publication
17182586 | J:141924
First Author: Zhang P
Year: 2007
Journal: J Immunol
Title: The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
Volume: 178
Issue: 1
Pages: 474-9
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MP Term
MP:0010187 | decreased T follicular helper cell number
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MP Term
MP:0010186 | increased T follicular helper cell number
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MP Term
MP:0010189 | abnormal T follicular helper cell physiology
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MP Term
MP:0010184 | abnormal T follicular helper cell morphology
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MP Term
MP:0010185 | abnormal T follicular helper cell number
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Publication
15917799 | J:98938
First Author: Vinuesa CG
Year: 2005
Journal: Nature
Title: A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.
Volume: 435
Issue: 7041
Pages: 452-8
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Publication
25261207 | -
 
First Author: Qi H
Year: 2014
Journal: Adv Exp Med Biol
Title: Tfh cell differentiation and their function in promoting B-cell responses.
Volume: 841
Pages: 153-80
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Protein Domain
IPR032671 | RC3H1
Type: Family
Description: Roquin-1 (RC3H1) is a post-transcriptional repressor required to repress follicular helper T cells (Tfh) and autoimmunity []. It binds to messenger RNAs (mRNAs) and regulates gene expression posttranscriptionally. For instance, it controls ICOS (inducible costimulator) expression through binding to the 3' UTR of ICOS mRNA and by interacting with proteins that confer post-transcriptional repression []. Besides ICOS, it also represses Ox40 and interferon-gamma in T cells, and this helps to prevent inappropriate T cell activation and Tfh cell differentiation [, ].Roquin-1 and its paralogue, Roquin-2 (Rc3h2), have been found to redundantly repress the mRNAs controlling T follicular helper cells and systemic inflammation [, ]. Tfhs are helper T-cells specialised in facilitating B-cell responses [].
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Allele
Pnp<bata> | MGI:5468722
 
Name: purine-nucleoside phosphorylase; bata
Allele Type: Chemically induced (ENU)
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Allele
Rhoa<tm1.1Tpal> | MGI:6401218
Name: ras homolog family member A; targeted mutation 1.1, Teresa Palomero
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Rc3h1/Rc3h1
Background: involves: C57BL/6 * C57BL/6JSfdAnu
Zygosity: ht
Has Mutant Allele: true
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MP Term
MP:0010188 | abnormal T follicular helper cell differentiation
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Allele
Bcl6<tm1.1Dent> | MGI:5518542
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Alexander Dent
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Id3<tm2.1Cmu> | MGI:5305600
Name: inhibitor of DNA binding 3; targeted mutation 2.1, Cornelis Murre
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Mir146/Mir146 Ighg1/Ighg1<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mir146/Mir146 Tg(CD2-icre)4Kio/?
Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
Zygosity: cn
Has Mutant Allele: true
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Allele
Bcl6<tm1.1Toka> | MGI:5140802
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Takaharu Okada
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Pten/Pten Tnfrsf4/Tnfrsf4<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Id3/Id3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pnp/Pnp
Background: C57BL/6JSfdAnu-Pnp
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40/Cd40<+> Mir146/Mir146 Tg(Cr2-cre)3Cgn/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mir146/Mir146 Mir146b/Mir146b Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rhoa/Rhoa<+> Tg(Cd4-cre/ERT2)11Gnri/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rc3h1/Rc3h1<+>
Background: involves: C57BL/6JSfdAnu
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl6/Bcl6 Tg(Cd4-cre)1Cwi/?
Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Allele
Mir146<tm1.1Lfl> | MGI:6359885
Name: microRNA 146; targeted mutation 1.1, Li-Fan Lu
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Bcl6/Bcl6
Background: involves: C57BL/6 * NZB
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rc3h1/Rc3h1 Rc3h2/Rc3h2
Background: involves: C57BL/6 * C57BL/6JSfdAnu
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mir146/Mir146 Tg(Cr2-cre)3Cgn/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
25697406 | J:221791
 
First Author: Srivastava M
Year: 2015
Journal: Nat Commun
Title: Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
Volume: 6
Pages: 6253
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Publication
31636135 | J:285064
 
First Author: Long X
Year: 2020
Journal: J Exp Med
Title: Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation.
Volume: 217
Issue: 1
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Publication
24859450 | J:215934
First Author: Wang H
Year: 2014
Journal: Nat Immunol
Title: The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells.
Volume: 15
Issue: 7
Pages: 667-75
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Publication
23812097 | J:201798
First Author: Kang SG
Year: 2013
Journal: Nat Immunol
Title: MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation.
Volume: 14
Issue: 8
Pages: 849-57
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Publication
26214741 | J:241194
First Author: Choi YS
Year: 2015
Journal: Nat Immunol
Title: LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Volume: 16
Issue: 9
Pages: 980-90
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Publication
18599325 | J:137869
First Author: Nurieva RI
Year: 2008
Journal: Immunity
Title: Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.
Volume: 29
Issue: 1
Pages: 138-49
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Publication
28228556 | J:252233
First Author: Zhang Z
Year: 2017
Journal: J Immunol
Title: Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability.
Volume: 198
Issue: 7
Pages: 2612-2625
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Publication
33637761 | J:304853
First Author: Yao Y
Year: 2021
Journal: Nat Commun
Title: METTL3-dependent m6A modification programs T follicular helper cell differentiation.
Volume: 12
Issue: 1
Pages: 1333
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Publication
30559442 | J:268329
First Author: Koizumi SI
Year: 2018
Journal: Nat Commun
Title: JunB regulates homeostasis and suppressive functions of effector regulatory T cells.
Volume: 9
Issue: 1
Pages: 5344
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Publication
31123085 | J:280051
First Author: Zhu Y
Year: 2019
Journal: J Exp Med
Title: The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control.
Volume: 216
Issue: 7
Pages: 1664-1681
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Publication
33207246 | J:300245
First Author: Su W
Year: 2020
Journal: Cell Metab
Title: Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells.
Volume: 32
Issue: 6
Pages: 996-1011.e7
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Publication
35021053 | J:335798
First Author: Chaurio RA
Year: 2022
Journal: Immunity
Title: TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.
Volume: 55
Issue: 1
Pages: 115-128.e9
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Publication
29398449 | J:257764
First Author: Cortes JR
Year: 2018
Journal: Cancer Cell
Title: RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.
Volume: 33
Issue: 2
Pages: 259-273.e7
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Publication
34471108 | J:310403
First Author: Hoefig KP
Year: 2021
Journal: Nat Commun
Title: Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.
Volume: 12
Issue: 1
Pages: 5208
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Publication
30082831 | J:301723
First Author: Takatsuka S
Year: 2018
Journal: Nat Immunol
Title: IL-9 receptor signaling in memory B cells regulates humoral recall responses.
Volume: 19
Issue: 9
Pages: 1025-1034
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Publication
16878136 | J:112657
First Author: Croxford JL
Year: 2006
Journal: Nat Immunol
Title: Invariant V(alpha)19i T cells regulate autoimmune inflammation.
Volume: 7
Issue: 9
Pages: 987-94
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Publication
28290453 | J:244924
 
First Author: Downs-Canner S
Year: 2017
Journal: Nat Commun
Title: Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Volume: 8
Pages: 14649
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Publication
37590141 | J:339618
First Author: Cohen GS
Year: 2023
Journal: Cell Rep
Title: Transplantation elicits a clonally diverse CD8(+) T cell response that is comprised of potent CD43(+) effectors.
Volume: 42
Issue: 8
Pages: 112993
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Publication
27637146 | J:254812
First Author: Zeng H
Year: 2016
Journal: Immunity
Title: mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.
Volume: 45
Issue: 3
Pages: 540-554
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Publication
16177065 | J:118994
First Author: Fields ML
Year: 2005
Journal: J Immunol
Title: CD4+ CD25+ regulatory T cells inhibit the maturation but not the initiation of an autoantibody response.
Volume: 175
Issue: 7
Pages: 4255-64
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Publication
23242415 | J:192538
First Author: Sage PT
Year: 2013
Journal: Nat Immunol
Title: The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.
Volume: 14
Issue: 2
Pages: 152-61
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Publication
23159227 | J:190440
First Author: Lee SK
Year: 2012
Journal: Immunity
Title: Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers.
Volume: 37
Issue: 5
Pages: 880-92
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Publication
25743066 | J:221898
 
First Author: Pratama A
Year: 2015
Journal: Nat Commun
Title: MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres.
Volume: 6
Pages: 6436
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Publication
16443792 | J:106844
First Author: Lundholm M
Year: 2006
Journal: Diabetes
Title: Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.
Volume: 55
Issue: 2
Pages: 538-44
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Publication
24138884 | J:208729
First Author: He J
Year: 2013
Journal: Immunity
Title: Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.
Volume: 39
Issue: 4
Pages: 770-81
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Publication
26146074 | J:224845
First Author: Sage PT
Year: 2015
Journal: Cell Rep
Title: Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.
Volume: 12
Issue: 2
Pages: 163-71
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Publication
28490441 | J:249056
First Author: Taylor S
Year: 2017
Journal: J Exp Med
Title: PD-1 regulates KLRG1+ group 2 innate lymphoid cells.
Volume: 214
Issue: 6
Pages: 1663-1678
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Publication
33795689 | J:305271
First Author: Tao H
Year: 2021
Journal: Nat Commun
Title: Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.
Volume: 12
Issue: 1
Pages: 2029
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Publication
34752418 | J:329521
 
First Author: Borges TJ
Year: 2021
Journal: JCI Insight
Title: Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms.
Volume: 6
Issue: 24
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Publication
36820828 | J:340867
 
First Author: Seth A
Year: 2023
Journal: J Exp Med
Title: AP-1-independent NFAT signaling maintains follicular T cell function in infection and autoimmunity.
Volume: 220
Issue: 5
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Allele
Prdm1<tm1Clme> | MGI:3605621
Name: PR domain containing 1, with ZNF domain; targeted mutation 1, Kathryn Calame
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Prdm1/Prdm1 Tg(Itgax-cre)1-1Reiz/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Allele
Ikzf4<tm1Djr> | MGI:6467011
Name: IKAROS family zinc finger 4; targeted mutation 1, Derrick Rossi
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Batf<tm1.1Ejt> | MGI:4459733
Name: basic leucine zipper transcription factor, ATF-like; targeted mutation 1.1, Elizabeth J Taparowsky
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pik3cd<tm2.1Tnr> | MGI:4850049
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; targeted mutation 2.1, Martin Turner
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tnfsf15<tm1Hluo> | MGI:5563219
Name: tumor necrosis factor (ligand) superfamily, member 15; targeted mutation 1, Hongyu Luo
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Bcl6<tm1.1Meln> | MGI:5502178
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Ari Melnick
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Allele
Bcl6<tm1.1Mtto> | MGI:5461311
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Toshitada Takemori
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Pik3cd/Pik3cd Tnfrsf4/Tnfrsf4<+>
Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl6/Bcl6 Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rnaseh2b/Rnaseh2b<+> Tlr7/Tlr7<+>
Background: C57BL/6NCrl-Rnaseh2b Tlr7
Zygosity: cx
Has Mutant Allele: true
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Allele
Rc3h1<san> | MGI:3581675
 
Name: RING CCCH (C3H) domains 1; sanroque
Allele Type: Chemically induced (ENU)
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Allele
Itfg2<Gt(OST215121)Lex> | MGI:4235940
Name: integrin alpha FG-GAP repeat containing 2; gene trap OST215121, Lexicon Genetics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Batf/Batf
Background: involves: 129S/Sv * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pik3cd/Pik3cd Tg(Cd4-cre)1Cwi/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bcl6/Bcl6
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rc3h1/Rc3h1 Rc3h2/Rc3h2 Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6N * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tnfsf15/Tnfsf15
Background: D1LacJ.129(B6)-Tnfsf15
Zygosity: hm
Has Mutant Allele: true
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