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Search results 901 to 914 out of 914 for Mdk

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0.018s

Type

Details

Score

Protein Coding Gene

MGI:97816 | Ptprz1

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

B9EKR1

Organism:	Mus musculus/domesticus
Length:	2312
Fragment?:	false

•

Strain

MGI:5003605 | STOCK Tg(Mdk-EGFP)DJ208Gsat/Mmucd

Attribute String:

mutant stock, transgenic

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Publication

15226403 | -

First Author:	Motegi A
Year:	2004
Journal:	J Cell Sci
Title:	ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Volume:	117
Issue:	Pt 15
Pages:	3319-29

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Publication

11121404 | -

First Author:	Souttou B
Year:	2001
Journal:	J Biol Chem
Title:	Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.
Volume:	276
Issue:	12
Pages:	9526-31

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Publication

17274988 | -

First Author:	Degoutin J
Year:	2007
Journal:	FEBS Lett
Title:	ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.
Volume:	581
Issue:	4
Pages:	727-34

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Publication

12107166 | -

First Author:	Bowden ET
Year:	2002
Journal:	J Biol Chem
Title:	Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.
Volume:	277
Issue:	39
Pages:	35862-8

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Publication

11278720 | -

First Author:	Stoica GE
Year:	2001
Journal:	J Biol Chem
Title:	Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.
Volume:	276
Issue:	20
Pages:	16772-9

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Publication

12122009 | -

First Author:	Stoica GE
Year:	2002
Journal:	J Biol Chem
Title:	Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.
Volume:	277
Issue:	39
Pages:	35990-8

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Protein Domain

IPR026830 | ALK

Type:

Family

Description:

ALK tyrosine kinase receptor (also known as anaplastic lymphoma kinase, ALK) is a neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system [].ALK transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 [, , ]. ALK acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation [, ]. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction [].

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Publication

24333171 | J:207902

First Author:	Kondoh S
Year:	2014
Journal:	Bone
Title:	Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice.
Volume:	60

Pages:	68-77

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Publication

8056766 | J:28529

First Author:	Obama H
Year:	1994
Journal:	J Biochem
Title:	The midkine (MK) family of growth/differentiation factors: structure of an MK-related sequence in a pseudogene and evolutionary relationships among members of the MK family.
Volume:	115
Issue:	3
Pages:	516-22

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Publication

19005166 | J:145888

First Author:	Wang S
Year:	2009
Journal:	Biol Reprod
Title:	ADP-ribosylation factor 1 regulates asymmetric cell division in female meiosis in the mouse.
Volume:	80
Issue:	3
Pages:	555-62

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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