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Search results 301 to 312 out of 312 for Ogdh

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0.016s

Type

Details

Score

Publication

1554728 | -

First Author:	Robien MA
Year:	1992
Journal:	Biochemistry
Title:	Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli.
Volume:	31
Issue:	13
Pages:	3463-71

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Publication

16442803 | -

First Author:	Brautigam CA
Year:	2006
Journal:	Structure
Title:	Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.
Volume:	14
Issue:	3
Pages:	611-21

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Publication

24077172 | -

First Author:	Kumaran S
Year:	2013
Journal:	Molecules
Title:	Nuclear magnetic resonance approaches in the study of 2-oxo acid dehydrogenase multienzyme complexes--a literature review.
Volume:	18
Issue:	10
Pages:	11873-903

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Protein Domain

IPR004167 | PSBD

Type:

Domain

Description:

The ubiquitous 2-oxoacid dehydrogenases are a family of very large multienzymecomplexes consisting of multiple copies of at least three enzymes whichcatalyze the oxidative decarboxylation of several different 2-oxoacids,resulting in acyl-CoA products. Members of this family include pyruvatedehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxoacid dehydrogenase (BCDH). The three enzymes assembling to form thesecomplexes are the decarboxylase E1 (called E1p, E1o and E1b in PDH, OGDH andBCDH, respectively), dihydrolipoamide acetyl, succinyl and branched-chaintransferase E2 (E2p, E2o and E2b, respectively) and dihydrolipoamidedehydrogenase E3. The E3 component is identical in all three complexes (PDH,OGDH and BCDH) and catalyzes the same reaction. The structural core of all 2-oxoacid dehydrogenase complexes (ODHc) is formed of multiple copies of E2subunits, with the E1 and E3 subunits bound on the periphery. The E2 componentof the ODHc's of both bacteria and eukaryotes serves as the structural core ofthese multienzyme complexes and is comprised of three types of domains.Starting with the N terminus, there are 1-3 tandem repeated lipoyl domains(LD), followed by a peripheral subunit-binding domain (PSBD)responsible for binding E1/E3 chains. The third domain is the C-terminalcatalytic domain (CD). The individual domains are separated by long, flexiblelinker regions allowing large movements of the lipoyl domain(s) to enableactive site coupling. The PSBD domain binds E1 or E3, but not bothsimultaneously. The flexible linker allows the PSBD domain (associated witheither E1 or E3) to move quite freely with respect to the core formed E2catalytic domains [, , , , ].The ~35-residue PSBD domain has a compact structure consisting of two short,parallel α-helices (H1 and H2) separated by a loop (L1), a single helicalturn, and a further, less well-ordered loop (L2) (see PDB:1BAL). The compactstructure of the PSBD domain is stabilized mainly by hydrophobic interactions.The interactions between the PSBD domain and E3 are all mediated by chargedside chains, forming an 'electrostatic zipper'. The residues of the PSBDdomain involved in the interactions are all provided by helix H1 of thisdomain. Helix H2 of PSBD does not interact with E3, but may be involved inbinding E1 [, , ].

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Publication

8805537 | -

First Author:	Mande SS
Year:	1996
Journal:	Structure
Title:	Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase.
Volume:	4
Issue:	3
Pages:	277-86

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Publication

10966480 | -

First Author:	Perham RN
Year:	2000
Journal:	Annu Rev Biochem
Title:	Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.
Volume:	69

Pages:	961-1004

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Protein

P53395

Organism:	Mus musculus/domesticus
Length:	482
Fragment?:	false

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Protein

A2AWH8

Organism:	Mus musculus/domesticus
Length:	220
Fragment?:	false

•

Protein

A2AWH7

Organism:	Mus musculus/domesticus
Length:	218
Fragment?:	true

•

Protein

Q7TND9

Organism:	Mus musculus/domesticus
Length:	482
Fragment?:	false

•

Protein

Q8BMF4

Organism:	Mus musculus/domesticus
Length:	642
Fragment?:	false

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Protein

Q8BKZ9

Organism:	Mus musculus/domesticus
Length:	501
Fragment?:	false

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