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Search results 1 to 100 out of 565 for Hira

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
7290 | HIRA
Type: gene
Organism: human
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Gene
363849 | Hira
Type: gene
Organism: rat
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Gene
470138 | HIRA
Type: gene
Organism: chimpanzee
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Gene
486424 | HIRA
Type: gene
Organism: dog, domestic
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Gene
374074 | HIRA
Type: gene
Organism: chicken
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Gene
568076 | hira
Type: gene
Organism: zebrafish
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Gene
719142 | HIRA
Type: gene
Organism: macaque, rhesus
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Gene
101906870 | HIRA
Type: gene
Organism: cattle
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Gene
100495450 | hira
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR011494 | Hira
Type: Domain
Description: The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain .
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Protein Coding Gene
MGI:99430 | Hira
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61666
Organism: Mus musculus/domesticus
Length: 1015  
Fragment?: false
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Gene
8479 | HIRIP3
Type: gene
Organism: human
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GXD Expression
GXD Expression
 
Probe: MGI:5588110
Assay Type: Immunohistochemistry
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3522328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5588111
Age: postnatal adult
Image: 4 cerebellum Hira
Specimen Label: 4 cerebellum Hira
Detected: true
Specimen Num: 4
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Publication
11408777 | J:71757
 
First Author: Hira K
Year: 2001
Journal: Int Arch Allergy Immunol
Title: Establishment and characterization of a murine mast cell line derived from NC/Nga mice.
Volume: 125 Suppl 1
Pages: 67-70
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Publication
35112132 | J:330257
 
First Author: Smith R
Year: 2022
Journal: Development
Title: The H3.3 chaperone Hira complex orchestrates oocyte developmental competence.
Volume: 149
Issue: 5
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Publication
9731536 | J:289456
First Author: Magnaghi P
Year: 1998
Journal: Nat Genet
Title: HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3.
Volume: 20
Issue: 1
Pages: 74-7
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Publication
34242617 | J:310096
First Author: Murdaugh RL
Year: 2021
Journal: Stem Cell Reports
Title: The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells.
Volume: 16
Issue: 8
Pages: 2014-2028
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Publication
26549683 | J:309966
First Author: Nashun B
Year: 2015
Journal: Mol Cell
Title: Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis.
Volume: 60
Issue: 4
Pages: 611-25
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Publication
27518902 | J:236915
First Author: Dilg D
Year: 2016
Journal: PLoS One
Title: HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3.
Volume: 11
Issue: 8
Pages: e0161096
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Publication
33835048 | J:307815
First Author: Smith R
Year: 2021
Journal: Reproduction
Title: HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.
Volume: 161
Issue: 6
Pages: 697-707
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Publication
28600325 | J:249763
First Author: Valenzuela N
Year: 2017
Journal: J Cell Sci
Title: HIRA deficiency in muscle fibers causes hypertrophy and susceptibility to oxidative stress.
Volume: 130
Issue: 15
Pages: 2551-2563
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Publication
25512559 | J:217374
First Author: Rai TS
Year: 2014
Journal: Genes Dev
Title: HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia.
Volume: 28
Issue: 24
Pages: 2712-25
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Publication
28515277 | J:246099
First Author: Li Y
Year: 2017
Journal: J Cell Biol
Title: Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin.
Volume: 216
Issue: 7
Pages: 1975-1992
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Publication
34140513 | J:307956
First Author: Blake GET
Year: 2021
Journal: Nat Commun
Title: Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.
Volume: 12
Issue: 1
Pages: 3714
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Publication
26935106 | J:231593
First Author: Valenzuela N
Year: 2016
Journal: Dis Model Mech
Title: Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis.
Volume: 9
Issue: 3
Pages: 335-45
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Publication
25197097 | J:216491
First Author: Soni S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression.
Volume: 111
Issue: 37
Pages: 13337-42
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Publication
33417013 | J:316220
First Author: Jeanne M
Year: 2021
Journal: Hum Genet
Title: Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth.
Volume: 140
Issue: 6
Pages: 885-896
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Publication
8611624 | J:32513
First Author: Scamps C
Year: 1996
Journal: Biochim Biophys Acta
Title: The HIR protein family: isolation and characterization of a complete murine cDNA.
Volume: 1306
Issue: 1
Pages: 5-8
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Publication
11884616 | J:75491
First Author: Roberts C
Year: 2002
Journal: Mol Cell Biol
Title: Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality.
Volume: 22
Issue: 7
Pages: 2318-28
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Publication
9063745 | J:38619
First Author: Wilming LG
Year: 1997
Journal: Hum Mol Genet
Title: The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients.
Volume: 6
Issue: 2
Pages: 247-58
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Publication
15922569 | J:100803
First Author: van der Heijden GW
Year: 2005
Journal: Mech Dev
Title: Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.
Volume: 122
Issue: 9
Pages: 1008-22
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Publication
8111380 | J:32846
First Author: Halford S
Year: 1993
Journal: Hum Mol Genet
Title: Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease.
Volume: 2
Issue: 12
Pages: 2099-107
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Publication
11342215 | J:67540
First Author: Lorain S
Year: 2001
Journal: Biochim Biophys Acta
Title: Identification of human and mouse HIRA-interacting protein-5 (HIRIP5), two mammalian representatives in a family of phylogenetically conserved proteins with a role in the biogenesis of Fe/S proteins.
Volume: 1517
Issue: 3
Pages: 376-83
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GO Term
GO:0000417 | HIR complex
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Gene
361650 | Hirip3
Type: gene
Organism: rat
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Gene
479786 | HIRIP3
Type: gene
Organism: dog, domestic
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Gene
738777 | HIRIP3
Type: gene
Organism: chimpanzee
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Gene
539704 | HIRIP3
Type: gene
Organism: cattle
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Gene
100000570 | hirip3
Type: gene
Organism: zebrafish
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Gene
708004 | HIRIP3
Type: gene
Organism: macaque, rhesus
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Gene
100135124 | hirip3
Type: gene
Organism: frog, western clawed
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein HIRA
Type: chain
End: 1015
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Protein Coding Gene
MGI:2142364 | Hirip3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25087892 | J:212533
First Author: Lin CJ
Year: 2014
Journal: Dev Cell
Title: Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
Volume: 30
Issue: 3
Pages: 268-79
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Publication
32075733 | J:286991
First Author: Chen C
Year: 2020
Journal: Cell Rep
Title: HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis.
Volume: 30
Issue: 7
Pages: 2136-2149.e4
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Protein Domain
IPR019015 | HIRA_B_motif
Type: Conserved_site
Description: The HirA B (Histone regulatory homologue A binding) motif is the essential binding interface between and ASF1a, of approx. 40 residues. It forms an antiparallel β-hairpin that binds perpendicular to the strands of the β-sandwich of ASF1a N-terminal core domain, via β-sheet, salt bridge and van der Waals interactions []. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The HIR complex is composed of HIR1, HIR2, HIR3 and HPC2, and interacts with ASF1. The HIR complex cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
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Publication
20211137 | J:167956
First Author: Goldberg AD
Year: 2010
Journal: Cell
Title: Distinct factors control histone variant H3.3 localization at specific genomic regions.
Volume: 140
Issue: 5
Pages: 678-91
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Publication
23921552 | J:200067
First Author: Sarai N
Year: 2013
Journal: EMBO J
Title: WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.
Volume: 32
Issue: 17
Pages: 2392-406
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Publication
21414300 | J:171931
First Author: Yang JH
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Histone chaperones cooperate to mediate Mef2-targeted transcriptional regulation during skeletal myogenesis.
Volume: 407
Issue: 3
Pages: 541-7
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Publication
22705305 | J:185969
First Author: Song TY
Year: 2012
Journal: Biochem Biophys Res Commun
Title: The role of histone chaperones in osteoblastic differentiation of C2C12 myoblasts.
Volume: 423
Issue: 4
Pages: 726-32
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Publication
27184122 | J:240212
First Author: Devaraju P
Year: 2017
Journal: Mol Psychiatry
Title: Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.
Volume: 22
Issue: 9
Pages: 1313-1326
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Publication
18469815 | J:136969
First Author: Stark KL
Year: 2008
Journal: Nat Genet
Title: Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.
Volume: 40
Issue: 6
Pages: 751-60
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Protein Coding Gene
MGP_CAROLIEiJ_G0020558 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022584 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022561 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022589 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022356 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99430 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021883 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022325 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022457 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022432 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022524 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023049 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021625 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021929 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016263 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021453 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7851908 | J:21108
First Author: Mattei MG
Year: 1994
Journal: Genomics
Title: Mapping of the Tuple1 gene to mouse chromosome 16A-B1.
Volume: 23
Issue: 3
Pages: 717-8
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GXD Expression
GXD Expression
     
Probe: MGI:3663073
Assay Type: RT-PCR
Annotation Date: 2006-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611816
Stage: TS16
Assay Id: MGI:3663143
Age: embryonic day 10.0-10.5
Specimen Label: wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3663073
Assay Type: RT-PCR
Annotation Date: 2006-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611816
Stage: TS16
Assay Id: MGI:3663143
Age: embryonic day 10.0-10.5
Specimen Label: Df1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3028274
Age: postnatal adult
Image: 3
Specimen Label: Spleen
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5779865
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779878
Age: postnatal adult
Specimen Label: adult spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5779866
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779880
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:5779868
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779881
Age: postnatal adult
Specimen Label: adult spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5779869
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779882
Age: postnatal adult
Specimen Label: adult spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5779870
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779883
Age: postnatal adult
Specimen Label: adult spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5779871
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779885
Age: postnatal adult
Specimen Label: adult spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5779872
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779886
Age: postnatal adult
Specimen Label: adult spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5779873
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779887
Age: postnatal adult
Specimen Label: adult spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:35646
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779875
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:35648
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779888
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:35646
Assay Type: RNase protection
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5779877
Age: postnatal adult
Specimen Label: spleen
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3028274
Age: postnatal adult
Image: 3
Specimen Label: Kidney
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5779866
Assay Type: RT-PCR
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5779880
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:35646
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5779875
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:35648
Assay Type: Northern blot
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5779888
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:35646
Assay Type: RNase protection
Annotation Date: 2016-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5779877
Age: postnatal adult
Specimen Label: kidney
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Stage: TS17
Assay Id: MGI:3028147
Age: embryonic day 10.5
Image: 1
Specimen Label: fnm/fb
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689528
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Amygdala
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3028223
Age: postnatal adult
Image: 3
Specimen Label: Brainstem
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Specimen Label: 24 lb
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Specimen Label: 28 lb
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Specimen Label: 32 lb
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Specimen Label: 36 lb
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028026
Assay Type: RT-PCR
Annotation Date: 2012-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668117
Stage: TS17
Assay Id: MGI:5446016
Age: embryonic day 10.5
Image: 1
Specimen Label: 24 fnm
Detected: true
Specimen Num: 15
•
•
•
•
•




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