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Search results 1 to 100 out of 157 for Atxn1

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Category: Publication
Type Details Score
Publication
First Author: Jorgensen ND
Year: 2009
Journal: J Neurochem
Title: Phosphorylation of ATXN1 at Ser776 in the cerebellum.
Volume: 110
Issue: 2
Pages: 675-86
Publication  
First Author: Nitschke L
Year: 2021
Journal: JCI Insight
Title: Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
Volume: 6
Issue: 3
Publication      
First Author: Coffin SL
Year: 2022
Journal: Neuron
Title: Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.
Publication
First Author: Servadio A
Year: 1995
Journal: Nat Genet
Title: Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals.
Volume: 10
Issue: 1
Pages: 94-8
Publication
First Author: Davidson JD
Year: 2000
Journal: Hum Mol Genet
Title: Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein.
Volume: 9
Issue: 15
Pages: 2305-12
Publication
First Author: Tong X
Year: 2011
Journal: EMBO Rep
Title: Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway.
Volume: 12
Issue: 5
Pages: 428-35
Publication
First Author: Hong S
Year: 2002
Journal: Mol Cell Neurosci
Title: USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.
Volume: 20
Issue: 2
Pages: 298-306
Publication
First Author: Handler HP
Year: 2023
Journal: Neuron
Title: Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles.
Volume: 111
Issue: 4
Pages: 493-507.e6
Publication
First Author: Lee Y
Year: 2011
Journal: Dev Cell
Title: ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Volume: 21
Issue: 4
Pages: 746-57
Publication
First Author: Ma Q
Year: 2021
Journal: Mol Brain
Title: The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells.
Volume: 14
Issue: 1
Pages: 19
Publication
First Author: Ingram M
Year: 2016
Journal: Neuron
Title: Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.
Volume: 89
Issue: 6
Pages: 1194-1207
Publication
First Author: Asher M
Year: 2021
Journal: Sci Rep
Title: Mood alterations in mouse models of Spinocerebellar Ataxia type 1.
Volume: 11
Issue: 1
Pages: 713
Publication  
First Author: Cvetanovic M
Year: 2015
Journal: Neuroscience
Title: Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.
Volume: 289
Pages: 289-99
Publication
First Author: Duvick L
Year: 2010
Journal: Neuron
Title: SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Volume: 67
Issue: 6
Pages: 929-35
Publication  
First Author: Öz G
Year: 2015
Journal: Neurobiol Dis
Title: Assessing recovery from neurodegeneration in spinocerebellar ataxia 1: Comparison of in vivo magnetic resonance spectroscopy with motor testing, gene expression and histology.
Volume: 74
Pages: 158-66
Publication
First Author: Ebner BA
Year: 2013
Journal: J Neurosci
Title: Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
Volume: 33
Issue: 13
Pages: 5806-20
Publication
First Author: Cvetanovic M
Year: 2011
Journal: Nat Med
Title: Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1.
Volume: 17
Issue: 11
Pages: 1445-7
Publication    
First Author: Lasagna-Reeves CA
Year: 2015
Journal: Elife
Title: Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes.
Volume: 4
Publication
First Author: Cvetanovic M
Year: 2012
Journal: Neurobiol Dis
Title: LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.
Volume: 48
Issue: 3
Pages: 526-32
Publication
First Author: Bowman AB
Year: 2007
Journal: Nat Genet
Title: Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
Volume: 39
Issue: 3
Pages: 373-9
Publication
First Author: Ju H
Year: 2013
Journal: J Neurosci
Title: Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
Volume: 33
Issue: 22
Pages: 9328-36
Publication
First Author: Zhang S
Year: 2020
Journal: Nat Commun
Title: The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways.
Volume: 11
Issue: 1
Pages: 3343
Publication
First Author: Barnes JA
Year: 2011
Journal: J Neurosci
Title: Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice.
Volume: 31
Issue: 36
Pages: 12778-89
Publication
First Author: Sánchez I
Year: 2013
Journal: Hum Mol Genet
Title: A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.
Volume: 22
Issue: 17
Pages: 3425-37
Publication
First Author: Edamakanti CR
Year: 2018
Journal: J Clin Invest
Title: Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1.
Volume: 128
Issue: 6
Pages: 2252-2265
Publication  
First Author: Takechi Y
Year: 2013
Journal: Neurosci Lett
Title: Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice.
Volume: 535
Pages: 67-72
Publication  
First Author: Orengo JP
Year: 2018
Journal: Dis Model Mech
Title: Motor neuron degeneration correlates with respiratory dysfunction in SCA1.
Volume: 11
Issue: 2
Publication
First Author: Asher M
Year: 2020
Journal: Hum Mol Genet
Title: Cerebellar contribution to the cognitive alterations in SCA1: evidence from mouse models.
Volume: 29
Issue: 1
Pages: 117-131
Publication    
First Author: Lasagna-Reeves CA
Year: 2015
Journal: Elife
Title: A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.
Volume: 4
Publication
First Author: Fryer JD
Year: 2011
Journal: Science
Title: Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua.
Volume: 334
Issue: 6056
Pages: 690-3
Publication
First Author: Park J
Year: 2013
Journal: Nature
Title: RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Volume: 498
Issue: 7454
Pages: 325-331
Publication
First Author: Fujita K
Year: 2017
Journal: Nat Commun
Title: Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.
Volume: 8
Issue: 1
Pages: 1864
Publication
First Author: Gall-Duncan T
Year: 2023
Journal: Cell
Title: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Volume: 186
Issue: 22
Pages: 4898-4919.e25
Publication
First Author: Serra HG
Year: 2006
Journal: Cell
Title: RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
Volume: 127
Issue: 4
Pages: 697-708
Publication
First Author: Lim J
Year: 2008
Journal: Nature
Title: Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
Volume: 452
Issue: 7188
Pages: 713-8
Publication
First Author: Jorgensen ND
Year: 2007
Journal: J Neurochem
Title: Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.
Volume: 102
Issue: 6
Pages: 2040-8
Publication  
First Author: Asher M
Year: 2016
Journal: Neuroscience
Title: Ataxin-1 regulates proliferation of hippocampal neural precursors.
Volume: 322
Pages: 54-65
Publication
First Author: Jafar-Nejad P
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration.
Volume: 108
Issue: 5
Pages: 2142-7
Publication
First Author: Gehrking KM
Year: 2011
Journal: Hum Mol Genet
Title: Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
Volume: 20
Issue: 11
Pages: 2204-12
Publication
First Author: Venkatraman A
Year: 2014
Journal: Hum Mol Genet
Title: The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
Volume: 23
Issue: 14
Pages: 3733-45
Publication
First Author: Goold R
Year: 2007
Journal: Hum Mol Genet
Title: Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1.
Volume: 16
Issue: 17
Pages: 2122-34
Publication
First Author: Ito H
Year: 2015
Journal: EMBO Mol Med
Title: HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.
Volume: 7
Issue: 1
Pages: 78-101
Publication
First Author: Crespo-Barreto J
Year: 2010
Journal: PLoS Genet
Title: Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
Volume: 6
Issue: 7
Pages: e1001021
Publication
First Author: Suh J
Year: 2019
Journal: Cell
Title: Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Volume: 178
Issue: 5
Pages: 1159-1175.e17
Publication
First Author: Didonna A
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis.
Volume: 117
Issue: 38
Pages: 23742-23750
Publication
First Author: Sánchez I
Year: 2016
Journal: Hum Mol Genet
Title: Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).
Volume: 25
Issue: 18
Pages: 4021-4040
Publication
First Author: Rousseaux MWC
Year: 2018
Journal: Neuron
Title: ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Volume: 97
Issue: 6
Pages: 1235-1243.e5
Publication
First Author: Klement IA
Year: 1998
Journal: Cell
Title: Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.
Volume: 95
Issue: 1
Pages: 41-53
Publication
First Author: Watase K
Year: 2002
Journal: Neuron
Title: A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.
Volume: 34
Issue: 6
Pages: 905-19
Publication
First Author: Burright EN
Year: 1995
Journal: Cell
Title: SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat.
Volume: 82
Issue: 6
Pages: 937-48
Publication
First Author: Clark HB
Year: 1997
Journal: J Neurosci
Title: Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.
Volume: 17
Issue: 19
Pages: 7385-95
Publication
First Author: Skinner PJ
Year: 1997
Journal: Nature
Title: Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures.
Volume: 389
Issue: 6654
Pages: 971-4
Publication    
First Author: Driessen TM
Year: 2018
Journal: Elife
Title: Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1.
Volume: 7
Publication
First Author: Lorenzetti D
Year: 2000
Journal: Hum Mol Genet
Title: Repeat instability and motor incoordination in mice with a targeted expanded CAG repeat in the Sca1 locus.
Volume: 9
Issue: 5
Pages: 779-85
Publication  
First Author: Sucha M
Year: 2023
Journal: Int J Mol Sci
Title: Experimental Treatment with Edaravone in a Mouse Model of Spinocerebellar Ataxia 1.
Volume: 24
Issue: 13
Publication  
First Author: Hatanaka Y
Year: 2015
Journal: Sci Rep
Title: Abnormalities in synaptic dynamics during development in a mouse model of spinocerebellar ataxia type 1.
Volume: 5
Pages: 16102
Publication
First Author: Tichanek F
Year: 2020
Journal: Sci Rep
Title: Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model.
Volume: 10
Issue: 1
Pages: 5418
Publication
First Author: Chen KA
Year: 2011
Journal: Mol Cell Neurosci
Title: Cellular fusion for gene delivery to SCA1 affected Purkinje neurons.
Volume: 47
Issue: 1
Pages: 61-70
Publication  
First Author: Luttik K
Year: 2022
Journal: Cells
Title: Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex.
Volume: 11
Issue: 17
Publication
First Author: Perroud B
Year: 2013
Journal: PLoS One
Title: Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects.
Volume: 8
Issue: 8
Pages: e70610
Publication
First Author: Matilla A
Year: 1998
Journal: J Neurosci
Title: Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation.
Volume: 18
Issue: 14
Pages: 5508-16
Publication
First Author: Shahbazian MD
Year: 2001
Journal: Neurobiol Dis
Title: Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion.
Volume: 8
Issue: 6
Pages: 974-81
Publication
First Author: Clark HB
Year: 2000
Journal: J Neuropathol Exp Neurol
Title: Spinocerebellar ataxia type 1--modeling the pathogenesis of a polyglutamine neurodegenerative disorder in transgenic mice.
Volume: 59
Issue: 4
Pages: 265-70
Publication
First Author: Limprasert P
Year: 1997
Journal: Am J Med Genet
Title: Comparative studies of the CAG repeats in the spinocerebellar ataxia type 1 (SCA1) gene.
Volume: 74
Issue: 5
Pages: 488-93
Publication
First Author: Emamian ES
Year: 2003
Journal: Neuron
Title: Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
Volume: 38
Issue: 3
Pages: 375-87
Publication
First Author: Banfi S
Year: 1996
Journal: Hum Mol Genet
Title: Cloning and developmental expression analysis of the murine homolog of the spinocerebellar ataxia type 1 gene (Sca1).
Volume: 5
Issue: 1
Pages: 33-40
Publication
First Author: Matilla A
Year: 1997
Journal: Nature
Title: The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1.
Volume: 389
Issue: 6654
Pages: 974-8
Publication
First Author: Gennarino VA
Year: 2015
Journal: Cell
Title: Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.
Volume: 160
Issue: 6
Pages: 1087-98
Publication
First Author: Mizutani A
Year: 2005
Journal: EMBO J
Title: Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.
Volume: 24
Issue: 18
Pages: 3339-51
Publication
First Author: de Chiara C
Year: 2003
Journal: FEBS Lett
Title: The AXH module: an independently folded domain common to ataxin-1 and HBP1.
Volume: 551
Issue: 1-3
Pages: 107-12
Publication  
First Author: Blot FGC
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice.
Volume: 118
Issue: 36
Publication
First Author: Pilotto F
Year: 2023
Journal: Neuron
Title: Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1.
Volume: 111
Issue: 16
Pages: 2523-2543.e10
Publication
First Author: Taniguchi JB
Year: 2016
Journal: Hum Mol Genet
Title: RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair.
Volume: 25
Issue: 20
Pages: 4432-4447
Publication
First Author: Cummings CJ
Year: 1999
Journal: Neuron
Title: Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.
Volume: 24
Issue: 4
Pages: 879-92
Publication
First Author: Lin X
Year: 2000
Journal: Nat Neurosci
Title: Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.
Volume: 3
Issue: 2
Pages: 157-63
Publication
First Author: Dion V
Year: 2008
Journal: Hum Mol Genet
Title: Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.
Volume: 17
Issue: 9
Pages: 1306-17
Publication
First Author: Hearst SM
Year: 2010
Journal: J Neurochem
Title: Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.
Volume: 114
Issue: 3
Pages: 706-16
Publication  
First Author: Shuvaev AN
Year: 2021
Journal: Neurobiol Dis
Title: Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1.
Volume: 154
Pages: 105340
Publication
First Author: Hubert L Jr
Year: 2011
Journal: Hum Mol Genet
Title: Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.
Volume: 20
Issue: 24
Pages: 4822-30
Publication
First Author: Herrmann F
Year: 2021
Journal: Sci Rep
Title: Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.
Volume: 11
Issue: 1
Pages: 17977
Publication
First Author: Takeuchi T
Year: 1997
Journal: Genomics
Title: jumonji gene maps to mouse chromosome 13.
Volume: 45
Issue: 1
Pages: 240-2
Publication
First Author: de Chiara C
Year: 2008
Journal: FEBS J
Title: Structural bases for recognition of Anp32/LANP proteins.
Volume: 275
Issue: 10
Pages: 2548-60
Publication
First Author: Yang P
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Maternal diabetes and high glucose in vitro trigger Sca1+ cardiac progenitor cell apoptosis through FoxO3a.
Volume: 482
Issue: 4
Pages: 575-581
Publication
First Author: Pasteris NG
Year: 2000
Journal: Gene
Title: Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue.
Volume: 242
Issue: 1-2
Pages: 237-47
Publication
First Author: Suzuki N
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche.
Volume: 103
Issue: 7
Pages: 2202-7
Publication
First Author: Cummings CJ
Year: 2001
Journal: Hum Mol Genet
Title: Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.
Volume: 10
Issue: 14
Pages: 1511-8
Publication
First Author: Le Roy-Duflos I
Year: 2001
Journal: Behav Genet
Title: Possible causal relationships between cerebellar patterns of foliation and hindlimb coordination in laboratory mice: a quantitative trait locus analysis.
Volume: 31
Issue: 1
Pages: 29-37
Publication
First Author: Gatchel JR
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7.
Volume: 105
Issue: 4
Pages: 1291-6
Publication
First Author: Chen G
Year: 2018
Journal: Eur J Immunol
Title: Sca-1+ cardiac fibroblasts promote development of heart failure.
Volume: 48
Issue: 9
Pages: 1522-1538
Publication
First Author: Servadio A
Year: 1995
Journal: Genomics
Title: Mapping of the Sca1 and pcd genes on mouse chromosome 13 provides evidence that they are different genes.
Volume: 29
Issue: 3
Pages: 812-3
Publication
First Author: Skinner PJ
Year: 2001
Journal: Am J Pathol
Title: Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice.
Volume: 159
Issue: 3
Pages: 905-13
Publication
First Author: Yu A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition.
Volume: 111
Issue: 15
Pages: E1481-90
Publication
First Author: Ruegsegger C
Year: 2016
Journal: Neuron
Title: Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology.
Volume: 89
Issue: 1
Pages: 129-46
Publication
First Author: Orr HT
Year: 2000
Journal: Neurobiol Dis
Title: The ins and outs of a polyglutamine neurodegenerative disease: spinocerebellar ataxia type 1 (SCA1).
Volume: 7
Issue: 3
Pages: 129-34
Publication
First Author: Bygrave AM
Year: 2023
Journal: Cell Rep
Title: Btbd11 supports cell-type-specific synaptic function.
Volume: 42
Issue: 6
Pages: 112591
Publication
First Author: Irwin S
Year: 2005
Journal: J Cell Sci
Title: RNA association and nucleocytoplasmic shuttling by ataxin-1.
Volume: 118
Issue: Pt 1
Pages: 233-42
Publication
First Author: Nadin BM
Year: 2003
Journal: Blood
Title: Phenotype and hematopoietic potential of side population cells throughout embryonic development.
Volume: 102
Issue: 7
Pages: 2436-43
Publication
First Author: Le Grand F
Year: 2004
Journal: Exp Cell Res
Title: Endothelial cells within embryonic skeletal muscles: a potential source of myogenic progenitors.
Volume: 301
Issue: 2
Pages: 232-41
Publication
First Author: Dominov JA
Year: 2001
Journal: Dev Dyn
Title: Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis.
Volume: 220
Issue: 1
Pages: 18-26
Publication
First Author: Passman JN
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells.
Volume: 105
Issue: 27
Pages: 9349-54