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Search results 101 to 143 out of 143 for Vac14

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0.027s

Type

Details

Score

Gene

447315 | vac14.L

Type:	gene
Organism:	frog, African clawed

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UniProt Feature

Begin:	1
Description:	Protein VAC14 homolog
Type:	chain
End:	782

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Allele

Vac14<ingls> | MGI:2675671

Name:	Vac14 homolog (S. cerevisiae); infantile gliosis
Allele Type:	Spontaneous
Attribute String:	Hypomorph

•

Allele

Vac14<+> | MGI:2441355

Name:	Vac14 homolog (S. cerevisiae); wild type

•

Allele

Vac14<Gt(OST39421)Lex> | MGI:4156337

Name:	Vac14 homolog (S. cerevisiae); gene trap OST39421, Lexicon Genetics
Allele Type:	Gene trapped

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Strain

MGI:2174039 | B6.D2-Vac14<ingls>/GrsrJ

Attribute String:

congenic, mutant stock, spontaneous mutation

•

Allele

Vac14<Gt(CSH692)Byg> | MGI:3878927

Name:	Vac14 homolog (S. cerevisiae); gene trap CSH692, BayGenomics
Allele Type:	Gene trapped

•

Allele

Vac14<Gt(CSI637)Byg> | MGI:3879391

Name:	Vac14 homolog (S. cerevisiae); gene trap CSI637, BayGenomics
Allele Type:	Gene trapped

•

Allele

Vac14<Gt(XE337)Byg> | MGI:4124764

Name:	Vac14 homolog (S. cerevisiae); gene trap XE337, BayGenomics
Allele Type:	Gene trapped

•

Allele

Vac14<Gt(RRP155)Byg> | MGI:3766320

Name:	Vac14 homolog (S. cerevisiae); gene trap RRP155, BayGenomics
Allele Type:	Gene trapped
Attribute String:	Null/knockout

•

Allele

Vac14<Gt(CSI629)Byg> | MGI:3879397

Name:	Vac14 homolog (S. cerevisiae); gene trap CSI629, BayGenomics
Allele Type:	Gene trapped

•

Genotype

Symbol:	Vac14/Vac14
Background:	B6.D2-Vac14/GrsrJ
Zygosity:	hm
Has Mutant Allele:	true

•

Allele

Vac14<tm1a(KOMP)Mbp> | MGI:4462534

Name:	Vac14 homolog (S. cerevisiae); targeted mutation 1a, Mouse Biology Program, UC Davis
Allele Type:	Targeted
Attribute String:	Conditional ready, Null/knockout, Reporter

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Allele

Vac14<tm1e(KOMP)Mbp> | MGI:4462485

Name:	Vac14 homolog (S. cerevisiae); targeted mutation 1e, Mouse Biology Program, UC Davis
Allele Type:	Targeted
Attribute String:	Null/knockout, Reporter

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Genotype

Symbol:	Vac14/Vac14
Background:	involves: 129P2/OlaHsd * C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Vac14/Vac14
Background:	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Zygosity:	ht
Has Mutant Allele:	true

•

Allele

Pikfyve<Gt(AT0926)Wtsi> | MGI:3853063

Name:	phosphoinositide kinase, FYVE type zinc finger containing; gene trap AT0926, Wellcome Trust Sanger Institute
Allele Type:	Gene trapped
Attribute String:	Null/knockout, Reporter

•

Genotype

Symbol:	Pikfyve/Pikfyve
Background:	involves: 129P2/OlaHsd * C57BL/6
Zygosity:	hm
Has Mutant Allele:	true

•

Publication

17556371 | J:137431

First Author:	Sbrissa D
Year:	2007
Journal:	J Biol Chem
Title:	Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.
Volume:	282
Issue:	33
Pages:	23878-91

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Publication

32188273 | J:325207

First Author:	Qin Y
Year:	2020
Journal:	Arterioscler Thromb Vasc Biol
Title:	Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.
Volume:	40
Issue:	5
Pages:	1311-1324

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Protein Domain

IPR021841 | VAC14_Fig4p-bd

Type:

Domain

Description:

Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes) []. This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system [].This entry represents the C-terminal domain of Vac14, which binds to Fig4p.

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Publication

29584722 | J:262141

First Author:	Liggins MC
Year:	2018
Journal:	PLoS Genet
Title:	PIKfyve regulates melanosome biogenesis.
Volume:	14
Issue:	3
Pages:	e1007290

•

Publication

30066585 | J:281797

First Author:	Michgehl U
Year:	2018
Journal:	Am J Physiol Renal Physiol
Title:	Nephron-specific knockin of the PIKfyve-binding-deficient Vac14^L156R mutant results in albuminuria and mesangial expansion.
Volume:	315
Issue:	5
Pages:	F1307-F1319

•

Publication

23673157 | J:199213

First Author:	Ikonomov OC
Year:	2013
Journal:	Am J Physiol Endocrinol Metab
Title:	Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
Volume:	305
Issue:	1
Pages:	E119-31

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Protein

A0A087WS78

Organism:	Mus musculus/domesticus
Length:	66
Fragment?:	false

•

Protein

A0A087WQI1

Organism:	Mus musculus/domesticus
Length:	158
Fragment?:	false

•

Publication

11895483 | -

First Author:	Morishita M
Year:	2002
Journal:	Genes Cells
Title:	Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe.
Volume:	7
Issue:	2
Pages:	199-215

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Publication

30427760 | -

First Author:	Miner GE
Year:	2019
Journal:	Mol Biol Cell
Title:	Phosphatidylinositol 3,5-bisphosphate regulates the transition between trans-SNARE complex formation and vacuole membrane fusion.
Volume:	30
Issue:	2
Pages:	201-208

•

Publication

19846542 | -

First Author:	Whitley P
Year:	2009
Journal:	Plant Physiol
Title:	Arabidopsis FAB1/PIKfyve proteins are essential for development of viable pollen.
Volume:	151
Issue:	4
Pages:	1812-22

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Publication

21412048 | -

First Author:	Hirano T
Year:	2011
Journal:	Plant Signal Behav
Title:	Arabidopsis FAB1A/B is possibly involved in the recycling of auxin transporters.
Volume:	6
Issue:	4
Pages:	583-5

•

Publication

18950639 | J:168949

First Author:	Sbrissa D
Year:	2008
Journal:	J Mol Biol
Title:	ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.
Volume:	384
Issue:	4
Pages:	766-79

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Publication

23757022 | -

First Author:	Er EE
Year:	2013
Journal:	Sci Signal
Title:	AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.
Volume:	6
Issue:	279
Pages:	ra45

•

Protein Domain

IPR043548 | PIKfyve

Type:

Family

Description:

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). It catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. The dynamic interconversion of PI3P and PI(3,5)P2 is regulated by a protein complex which is conserved from yeast to mammals. It includes at least five proteins in yeast, located in the vacuole membrane: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p. Homologues of Fab1p, Vac14p and Fig4p are found in all eukaryotes which in mammalian cells, are known as Fab1/PIKfyve/PIP5K3, Fig4/Sac3, and Vac14/ArPIKfyve, located on early and late endosomes. Fab1, Vac14, and Fig4 form a ternary complex where Fab1 lipid kinase and Fig4 lipid phosphatase bind to opposite ends of Vac14. A conformational change of Vac14 allows a quick effect on kinase and phosphatase activities. This complex is required for endocytic-vacuolar pathway and nuclear migration. It plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes in mammals, being essential for nervous tissue function. It has been shown that alterations in this complex leads to reduced intracellular levels of PI(3,5)P2, cytoplasmic vacuolisation and neurodegeneration [, ].This entry represents the 1-phosphatidylinositol-3phosphate-5-kinase (PIKfyve) found in eukaryotes.

•

Protein Domain

IPR044769 | PIKfyve_PIPKc

Type:

Domain

Description:

This entry represents the C-terminal catalytic lipid kinase domain related to PtdInsP kinases (PIPKc domain) found in PIKfyve and related proteins.1-phosphatidylinositol-3-phosphate 5-kinase (), also called FYVE finger-containing phosphoinositide kinase (PIKfyve), forms a complex with its regulators, the scaffolding protein Vac14 and the lipid phosphatase Fig4. The complex synthesises phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2]through the phosphorylation of phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) on the fifth hydroxyl of the myo-inositol ring. Then phosphatidylinositol-5-phosphate (PtdIns5P) is generated directly from PtdIns(3,5)P2. PtdIns(3,5)P2 and PtdIns5P regulate endosomal trafficking and responses to extracellular stimuli []. It is vital in early embryonic development and plays a role in different pathways, such as receptor tyrosine kinase (RTK) or EGFR degradation, regulation of the glutamate transporters EAAT2, EAAT3 and EAAT4 and the cystic fibrosis transmembrane conductance regulator (CFTR). It is also essential for systemic glucose homeostasis and insulin-regulated glucose uptake/GLUT4 translocation in skeletal muscle [, , ].The yeast orthologue of human PIKfyve, Fab1, is required for endocytic-vacuolar pathway and nuclear migration [, ]. The plant orthologues such as FAB1A-D from Arabidopsis are important for the maintenance of endomembrane homeostasis and for development of viable pollen [, ].PIKfyve and its orthologues share a similar architecture consisting of a N-terminal FYVE domain, a middle region related to the CCT/TCP-1/Cpn60 chaperonins that are involved in productive folding of actin and tubulin, a second middle domain that contains a number of conserved cysteine residues (CCR) unique to these proteins, and a C-terminal catalytic lipid kinase domain related to PtdInsP kinases (or the PIPKc domain).

•

Protein

Q9Z1T6

Organism:	Mus musculus/domesticus
Length:	2097
Fragment?:	false

•

Protein

D3Z5N5

Organism:	Mus musculus/domesticus
Length:	2052
Fragment?:	false

•

Publication

11042159 | J:68323

First Author:	Carninci P
Year:	2000
Journal:	Genome Res
Title:	Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume:	10
Issue:	10
Pages:	1617-30

•

Publication

10349636 | J:80645

First Author:	Carninci P
Year:	1999
Journal:	Methods Enzymol
Title:	High-efficiency full-length cDNA cloning.
Volume:	303

Pages:	19-44

•

Publication

11076861 | J:68324

First Author:	Shibata K
Year:	2000
Journal:	Genome Res
Title:	RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume:	10
Issue:	11
Pages:	1757-71

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Publication

16141073 | -

First Author:	Katayama S
Year:	2005
Journal:	Science
Title:	Antisense transcription in the mammalian transcriptome.
Volume:	309
Issue:	5740
Pages:	1564-6

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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