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Search results 1101 to 1141 out of 1141 for Notch3

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0.021s

Type

Details

Score

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor Notch3/Notch3<+>
Background:	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

30226866 | J:266199

First Author:	Huang S
Year:	2018
Journal:	PLoS Biol
Title:	Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.
Volume:	16
Issue:	9
Pages:	e2005233

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Publication

23530123 | J:198219

First Author:	Van de Walle I
Year:	2013
Journal:	J Exp Med
Title:	Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
Volume:	210
Issue:	4
Pages:	683-97

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Publication

21118965 | J:166963

First Author:	Sullivan JP
Year:	2010
Journal:	Cancer Res
Title:	Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Volume:	70
Issue:	23
Pages:	9937-48

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Publication

37318881 | J:339975

First Author:	Sugiura K
Year:	2023
Journal:	JCI Insight
Title:	LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3.
Volume:	8
Issue:	14

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Publication

28266128 | J:271834

First Author:	Wang S
Year:	2017
Journal:	J Cell Mol Med
Title:	Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.
Volume:	21
Issue:	9
Pages:	1967-1978

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Publication

27613846 | J:274430

First Author:	Wang S
Year:	2016
Journal:	Oncotarget
Title:	Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling.
Volume:	7
Issue:	37
Pages:	58848-58861

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Publication

23630352 | J:204776

First Author:	Gopisetty A
Year:	2013
Journal:	J Immunol
Title:	OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells.
Volume:	190
Issue:	11
Pages:	5516-25

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Publication

31796853 | J:297963

First Author:	Klose R
Year:	2019
Journal:	Sci Rep
Title:	Loss of the serine protease HTRA1 impairs smooth muscle cells maturation.
Volume:	9
Issue:	1
Pages:	18224

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Publication

26868537 | J:263576

First Author:	Zeng H
Year:	2016
Journal:	Sci Rep
Title:	LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways.
Volume:	6

Pages:	20931

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Publication

28752390 | J:263753

First Author:	Cuervo H
Year:	2017
Journal:	Angiogenesis
Title:	PDGFRβ-P2A-CreER^T2 mice: a genetic tool to target pericytes in angiogenesis.
Volume:	20
Issue:	4
Pages:	655-662

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Publication

21994468 | J:205398

First Author:	Osanyingbemi-Obidi J
Year:	2011
Journal:	Mol Cancer Res
Title:	Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo.
Volume:	9
Issue:	12
Pages:	1746-54

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Publication

30502484 | J:282276

First Author:	Papadakos KS
Year:	2019
Journal:	Matrix Biol
Title:	Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.
Volume:	81

Pages:	107-121

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Publication

21743488 | J:181067

First Author:	Pradeep CR
Year:	2012
Journal:	Oncogene
Title:	Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.
Volume:	31
Issue:	7
Pages:	907-17

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Publication

31704879 | J:282061

First Author:	Kumar P
Year:	2019
Journal:	J Immunol
Title:	OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling.
Volume:	203
Issue:	12
Pages:	3225-3236

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Publication

36645109 | J:338757

First Author:	Li X
Year:	2023
Journal:	FASEB J
Title:	Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
Volume:	37
Issue:	2
Pages:	e22743

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Publication

19688092 | J:152461

First Author:	Dudley DD
Year:	2009
Journal:	PLoS One
Title:	Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.
Volume:	4
Issue:	8
Pages:	e6678

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Publication

20804727 | J:165587

First Author:	Bargo S
Year:	2010
Journal:	Biochem Biophys Res Commun
Title:	Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Volume:	400
Issue:	4
Pages:	606-12

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Publication

29206900 | J:261096

First Author:	Zhang C
Year:	2018
Journal:	Cardiovasc Res
Title:	Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation.
Volume:	114
Issue:	3
Pages:	443-455

•

Protein Domain

IPR022331 | Notch_3

Type:

Family

Description:

Notch cell surface receptors are large, single-pass type-1 transmembrane proteins found in a diverse range of metazoan species, from human to Caenorhabditis species. The fruit fly, Drosophila melanogaster, possesses only one Notch protein, whereas in C.elegans, two receptors have been found; by contrast, four Notch paralogues (designated N1-4) have been identified in mammals, playing both unique and redundant roles. The hetero-oligomer Notch comprises a large extracellular domain (ECD), containing 10-36 tandem Epidermal Growth Factor (EFG)-like repeats, which are involved in ligand interactions; a negative regulatory region, including three cysteine-rich Lin12-Notch Repeats (LNR); a single trans-membrane domain (TM); a small intracellular domain (ICD), which includes a RAM (RBPjk-association module) domain; six ankyrin repeats (ANK), which are involved in protein-protein interactions; and a PEST domain. Drosophila Notch also contains an OPA domain []. Notch signalling is an evolutionarily conserved pathway involved in a wide variety of developmental processes, including adult homeostasis and stem cell maintenance, cell proliferation and apoptosis []. Notch is activated by a range of ligands -the so-called DSL ligands (Delta/Seratte/LAG-2). Activation is also mediated by a sequence of proteolytic events: ligand binding leads to cleavage of Notch by ADAM proteases []at site 2 (S2) and presenilin-1/g-secretase at sites 3 (S3)and 4 (S4) [].The last cleavage releases the Notch intracellular part of the protein (NICD) from the membrane and, upon release, the NICD translocates to the nucleus where it associates with a CBF1/RBJk/Su(H)/Lag1 (CSL) family of DNA-binding proteins. The subsequent recruitment of a co-activator mastermind like (MAML1) protein []promotes transcriptional activation of Notch target genes: well established Notch targets are the Hes and Hey gene families. Aberrant Notch function and signalling has been associated with a number of human disorders, including Allagile syndrome, spondylocostal dysostosis, aortic valve disease, CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), and T-cell Acute Lympho-blastic Leukemia (T-ALL); it has also been implicated in various human carcinomas [, ]. Notch3 displays a more restrictive distribution than the rest of the Notch subtypes, being expressed predominantly in vascular smooth muscle cells, the central nervous system, certain thymocytes subsets, and in regulatory T cells [].

•

Publication

24039710 | J:225185

First Author:	Li L
Year:	2013
Journal:	PLoS One
Title:	Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction.
Volume:	8
Issue:	9
Pages:	e71041

•

Publication

35792302 | J:341865

First Author:	Breikaa RM
Year:	2022
Journal:	Vascul Pharmacol
Title:	Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes.
Volume:	145

Pages:	107087

•

Publication

26279302 | J:309335

First Author:	Zhang S
Year:	2016
Journal:	Oncogene
Title:	Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Volume:	35
Issue:	19
Pages:	2485-95

•

Publication

32325086 | J:314302

First Author:	Kunze B
Year:	2020
Journal:	Gastroenterology
Title:	Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma.
Volume:	159
Issue:	2
Pages:	575-590

•

Publication

36107978 | J:329263

First Author:	Alexander GM
Year:	2022
Journal:	PLoS One
Title:	Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease.
Volume:	17
Issue:	9
Pages:	e0274615

•

Publication

29162437 | J:277897

First Author:	Andersson ER
Year:	2018
Journal:	Gastroenterology
Title:	Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.
Volume:	154
Issue:	4
Pages:	1080-1095

•

Publication

19379690 | -

First Author:	Kopan R
Year:	2009
Journal:	Cell
Title:	The canonical Notch signaling pathway: unfolding the activation mechanism.
Volume:	137
Issue:	2
Pages:	216-33

•

Publication

12354787 | J:94943

First Author:	Hartmann D
Year:	2002
Journal:	Hum Mol Genet
Title:	The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Volume:	11
Issue:	21
Pages:	2615-24

•

Publication

11101851 | -

First Author:	Wu L
Year:	2000
Journal:	Nat Genet
Title:	MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Volume:	26
Issue:	4
Pages:	484-9

•

Publication

12668592 | J:82719

First Author:	Gridley T
Year:	2003
Journal:	Hum Mol Genet
Title:	Notch signaling and inherited disease syndromes.
Volume:	12 Spec No 1

Pages:	R9-13

•

Publication

16429119 | -

First Author:	Louvi A
Year:	2006
Journal:	Nat Rev Neurosci
Title:	Notch signalling in vertebrate neural development.
Volume:	7
Issue:	2
Pages:	93-102

•

Publication

10206645 | J:54336

First Author:	De Strooper B
Year:	1999
Journal:	Nature
Title:	A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Volume:	398
Issue:	6727
Pages:	518-22

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Protein Coding Gene

MGI:1925544 | Rps27a

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98887 | Uba52

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98888 | Ubb

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98889 | Ubc

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

P62984

Organism:	Mus musculus/domesticus
Length:	128
Fragment?:	false

•

Protein

P0CG50

Organism:	Mus musculus/domesticus
Length:	734
Fragment?:	false

•

Protein

P62983

Organism:	Mus musculus/domesticus
Length:	156
Fragment?:	false

•

Protein

P0CG49

Organism:	Mus musculus/domesticus
Length:	305
Fragment?:	false

•

Publication

10221902 | -

First Author:	Artavanis-Tsakonas S
Year:	1999
Journal:	Science
Title:	Notch signaling: cell fate control and signal integration in development.
Volume:	284
Issue:	5415
Pages:	770-6

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