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Search results 101 to 167 out of 167 for Dclre1c

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Type Details Score
Allele
Dclre1c<em1Smoc> | MGI:7289285
Name: DNA cross-link repair 1C; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Dclre1c<tm1Jsek> | MGI:3843046
 
Name: DNA cross-link repair 1C; targeted mutation 1, JoAnn Sekiguchi
Allele Type: Targeted
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Allele
Dclre1c<tm2Mcow> | MGI:3574021
Name: DNA cross-link repair 1C; targeted mutation 2, Morton J Cowan
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Dclre1c/Dclre1c
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dclre1c/Dclre1c
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Allele
Tg(Tyr-cre/ERT2)1Lru | MGI:3617509
Name: transgene insertion 1, Lionel Larue
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Protein Domain
IPR044107 | PIKKc_ATM
Type: Domain
Description: ATM acts as a DNA damage sensor upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA) [, ]. It regulate DNA damage response mechanism through recognising the substrate consensus sequence [ST]-Q and phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs) []. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active [, ]. It can phosphorylate DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C [, , , , ]. ATM is also required for telomere elongation []. ATM also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes []. It isalso involved in signal transduction and cell cycle control and may function as a tumour suppressor [].This entry represents the catalytic domain found in serine-protein kinase ATM.
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Publication
9707615 | -
First Author: Lim DS
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: ATM binds to beta-adaptin in cytoplasmic vesicles.
Volume: 95
Issue: 17
Pages: 10146-51
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Publication
11571274 | J:341403
First Author: Burma S
Year: 2001
Journal: J Biol Chem
Title: ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
Volume: 276
Issue: 45
Pages: 42462-7
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Publication
19448632 | J:149451
First Author: Hewitt SL
Year: 2009
Journal: Nat Immunol
Title: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
Volume: 10
Issue: 6
Pages: 655-64
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Publication
10973490 | -
First Author: Matsuoka S
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
Volume: 97
Issue: 19
Pages: 10389-94
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Publication
12556884 | -
First Author: Bakkenist CJ
Year: 2003
Journal: Nature
Title: DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
Volume: 421
Issue: 6922
Pages: 499-506
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Publication
16858402 | -
First Author: Kozlov SV
Year: 2006
Journal: EMBO J
Title: Involvement of novel autophosphorylation sites in ATM activation.
Volume: 25
Issue: 15
Pages: 3504-14
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Publication
10873394 | -
First Author: Becker-Catania SG
Year: 2000
Journal: Mol Genet Metab
Title: Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity.
Volume: 70
Issue: 2
Pages: 122-33
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Publication
8988033 | -
First Author: Jung M
Year: 1997
Journal: Cancer Res
Title: ATM gene product phosphorylates I kappa B-alpha.
Volume: 57
Issue: 1
Pages: 24-7
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Publication
9843217 | -
First Author: Khanna KK
Year: 1998
Journal: Nat Genet
Title: ATM associates with and phosphorylates p53: mapping the region of interaction.
Volume: 20
Issue: 4
Pages: 398-400
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Publication
10550055 | -
First Author: Cortez D
Year: 1999
Journal: Science
Title: Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Volume: 286
Issue: 5442
Pages: 1162-6
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Publication
10766245 | -
First Author: Lim DS
Year: 2000
Journal: Nature
Title: ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
Volume: 404
Issue: 6778
Pages: 613-7
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Publication
26586427 | J:228143
First Author: Lee SS
Year: 2015
Journal: Cell Rep
Title: ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells.
Volume: 13
Issue: 8
Pages: 1623-32
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Strain
MGI:6107859 | B6N.Cg-Tg(Tyr-cre/ERT2)1Lru/J
Attribute String: transgenic, mutant strain, congenic
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Publication
15680327 | J:96923
First Author: Park BJ
Year: 2005
Journal: Cell
Title: The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.
Volume: 120
Issue: 2
Pages: 209-21
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Protein Domain
IPR015519 | ATM/Tel1
Type: Family
Description: This family consists of serine/threonine protein kinases, including human ATM (Ataxia-Telangiectasia Mutated) and fungal Tel1.ATM acts as a DNA damage sensor upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA) [, ]. It regulate DNA damage response mechanism through recognizing the substrate consensus sequence [ST]-Q and phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs) []. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active [, ]. It can phosphorylate DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C [, , , , ]. ATM is also required for telomere elongation []. ATM also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes []. It is also involved in signal transduction and cell cycle control and may function as a tumour suppressor [].
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Publication
34417458 | J:308952
First Author: Diener J
Year: 2021
Journal: Nat Commun
Title: Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
Volume: 12
Issue: 1
Pages: 5056
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Publication
20516123 | J:161625
First Author: Milagre C
Year: 2010
Journal: Cancer Res
Title: A mouse model of melanoma driven by oncogenic KRAS.
Volume: 70
Issue: 13
Pages: 5549-57
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Publication
16419042 | J:105276
First Author: Yajima I
Year: 2006
Journal: Genesis
Title: Spatiotemporal gene control by the Cre-ERT2 system in melanocytes.
Volume: 44
Issue: 1
Pages: 34-43
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Publication
22820643 | J:317304
First Author: Gembarska A
Year: 2012
Journal: Nat Med
Title: MDM4 is a key therapeutic target in cutaneous melanoma.
Volume: 18
Issue: 8
Pages: 1239-47
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Publication
23303902 | J:198244
First Author: Pedersen M
Year: 2013
Journal: Cancer Discov
Title: Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.
Volume: 3
Issue: 4
Pages: 458-469
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Kras/Kras<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nras/Nras Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nras/Nras<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
31972251 | J:297200
First Author: Braun AD
Year: 2020
Journal: J Invest Dermatol
Title: Activated Hgf-Met Signaling Cooperates with Oncogenic BRAF to Drive Primary Cutaneous Melanomas and Angiotropic Lung Metastases in Mice.
Volume: 140
Issue: 7
Pages: 1410-1417.e2
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Publication
26511633 | J:230591
First Author: Hölzel M
Year: 2016
Journal: Cancer Res
Title: A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells.
Volume: 76
Issue: 2
Pages: 251-63
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Publication
19345328 | J:147434
First Author: Dhomen N
Year: 2009
Journal: Cancer Cell
Title: Oncogenic Braf induces melanocyte senescence and melanoma in mice.
Volume: 15
Issue: 4
Pages: 294-303
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Publication
20141835 | J:161180
First Author: Heidorn SJ
Year: 2010
Journal: Cell
Title: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Volume: 140
Issue: 2
Pages: 209-21
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Publication
24667377 | J:259219
First Author: Sanchez-Laorden B
Year: 2014
Journal: Sci Signal
Title: BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.
Volume: 7
Issue: 318
Pages: ra30
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Publication
34878101 | J:321576
 
First Author: Colombo S
Year: 2022
Journal: Development
Title: Stabilization of β-catenin promotes melanocyte specification at the expense of the Schwann cell lineage.
Volume: 149
Issue: 2
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Publication
31806640 | J:285658
First Author: Boussouar A
Year: 2020
Journal: Cancer Res
Title: Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression.
Volume: 80
Issue: 4
Pages: 747-756
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Publication
28658220 | J:249306
First Author: Olmeda D
Year: 2017
Journal: Nature
Title: Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.
Volume: 546
Issue: 7660
Pages: 676-680
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Publication
32503808 | J:293703
First Author: Vandamme N
Year: 2020
Journal: Cancer Res
Title: The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype.
Volume: 80
Issue: 14
Pages: 2983-2995
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Strain
MGI:5447425 | B6.Cg-Braf<tm1Mmcm> Tg(Tyr-cre/ERT2)1Lru Pten<tm1Mro>
Attribute String: congenic, mutant strain, targeted mutation
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Publication
27999416 | J:309460
 
First Author: Deken MA
Year: 2016
Journal: Int J Mol Sci
Title: Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in PtenLoxP/LoxP;BrafCA/+ Mice.
Volume: 17
Issue: 12
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Publication
22796458 | J:188523
First Author: Hooijkaas AI
Year: 2012
Journal: Am J Pathol
Title: Targeting BRAFV600E in an inducible murine model of melanoma.
Volume: 181
Issue: 3
Pages: 785-94
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Publication
22113477 | J:183166
First Author: Rae J
Year: 2012
Journal: J Invest Dermatol
Title: (V600E)Braf::Tyr-CreERT2::K14-Kitl mice do not develop superficial spreading-like melanoma: keratinocyte Kit ligand is insufficient to "translocate" (V600E)Braf-driven melanoma to the epidermis.
Volume: 132
Issue: 2
Pages: 488-91
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Publication
28647344 | J:252204
First Author: van Tuyn J
Year: 2017
Journal: J Invest Dermatol
Title: Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function.
Volume: 137
Issue: 10
Pages: 2197-2207
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Publication
32051401 | J:287086
First Author: Galvani E
Year: 2020
Journal: Nat Commun
Title: Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma.
Volume: 11
Issue: 1
Pages: 853
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Publication
30510256 | J:314412
First Author: Trucco LD
Year: 2019
Journal: Nat Med
Title: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.
Volume: 25
Issue: 2
Pages: 221-224
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Publication
32450073 | J:314307
First Author: Trucco LD
Year: 2021
Journal: J Invest Dermatol
Title: Map3k1 Loss Cooperates with BrafV600E to Drive Melanomagenesis.
Volume: 141
Issue: 1
Pages: 221-225.e6
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Publication
31679174 | J:282623
     
First Author: Aktary Z
Year: 2019
Journal: Pigment Cell Melanoma Res
Title: Sequencing two Tyr::CreERT2 transgenic mouse lines.
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Genotype
Genotype
Symbol: Braf/Braf Cdkn2a/Cdkn2a Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(GFP/KRAS2/ALPP)1Brn/? Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten Tg(Tyr-cre/ERT2)1Lru/?
Background: B6.Cg-Braf Tg(Tyr-cre/ERT2)1Lru Pten
Zygosity: cn
Has Mutant Allele: true
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Publication
26765561 | J:229442
 
First Author: Kümper S
Year: 2016
Journal: Elife
Title: Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Volume: 5
Pages: e12994
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Publication
30581152 | J:270032
First Author: Karras P
Year: 2019
Journal: Cancer Cell
Title: p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Volume: 35
Issue: 1
Pages: 46-63.e10
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Publication
23382837 | J:195917
First Author: Yajima I
Year: 2013
Journal: PLoS One
Title: A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus.
Volume: 8
Issue: 1
Pages: e53183
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Publication
33091424 | J:314330
First Author: Le Coz M
Year: 2021
Journal: J Invest Dermatol
Title: Targeted Knockout of β-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects.
Volume: 141
Issue: 5
Pages: 1363-1366.e9
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Publication
22718121 | J:335347
First Author: Li A
Year: 2012
Journal: J Invest Dermatol
Title: Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism.
Volume: 132
Issue: 11
Pages: 2610-21
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Publication
28497782 | J:335349
 
First Author: Dorard C
Year: 2017
Journal: Nat Commun
Title: RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma.
Volume: 8
Pages: 15262
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Publication
21924960 | J:178787
First Author: Li A
Year: 2011
Journal: Dev Cell
Title: Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.
Volume: 21
Issue: 4
Pages: 722-34
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Publication
34140478 | J:307915
First Author: Hamm M
Year: 2021
Journal: Nat Commun
Title: BRN2 is a non-canonical melanoma tumor-suppressor.
Volume: 12
Issue: 1
Pages: 3707
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Publication
25256614 | J:217894
First Author: Smith MP
Year: 2014
Journal: Cancer Discov
Title: The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFα.
Volume: 4
Issue: 10
Pages: 1214-1229
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Protein
F6UXV2
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
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Protein
Q6NX74
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: true
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Protein
Q62388
Organism: Mus musculus/domesticus
Length: 3066  
Fragment?: false
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Protein
B9EHX4
Organism: Mus musculus/domesticus
Length: 3063  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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