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Search results 301 to 315 out of 315 for Vps13a

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0.017s

Type

Details

Score

Protein Domain

IPR009543 | VPS13_VAB

Type:

Domain

Description:

This entry represents the VPS13 adaptor binding (VAB) domain, previously known as SHR-BD, found in VPS13 []. These proteins interact with membrane-specific adaptor proteins such as Ypt35, Spo71 and the mitochondrial membrane protein Mcp1, to be recruited to different membranes. This domain interacts with Ypt35 which recruits VPS13 to endosomal and vacuolar membranes, and with Mcp1 to target VPS13 at mitochondria []. In plants, this domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY () [].This domain likely adopts an elongated structure consisting of β-sheets. It has been described as a β-propeller/WD40-like structure [, ], however, based on structural models, it does not seem to have that 3D arrangement.VPS13 proteins have been implicated in processes including vesicle fusion, autophagy, and actin regulation. They bind phospholipids and act as channels that mediate the transfer of lipids between membranes at organelle contact sites [, , ]. It has been proposed that members of this entry have the capacity to bind and likely transfer tens of glycerolipids at once. Yeast VPS13 acts at multiple cellular sites, namely the interface between mitochondria and the vacuole, on endosomes, on the nuclear-vacuole junction and the vacuole, depending on the carbon source and metabolic state. Most evidence showed that mammalian VPS13A, VPS13C and VPS13D localize at contacts between the ER and other organelles, i.e. VPS13A and VPS13D bridge the ER to mitochondria, VPS13C bridges the ER to late endosomes and lysosomes and VPS13B may localize to endosome-endosome contacts [, , ]. Mutations in human VPS13 proteins (VPS13A-D) cause different diseases such as Chorea-acanthocytosis, Cohen syndrome, Parkinson's disease, and spastic ataxia, respectively which suggests they have different functions [, ].

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Publication

24405768 | J:206464

First Author:	Zhu X
Year:	2014
Journal:	Am J Pathol
Title:	Giant axon formation in mice lacking Kell, XK, or Kell and XK: animal models of McLeod neuroacanthocytosis syndrome.
Volume:	184
Issue:	3
Pages:	800-7

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Protein

Q6P4T0

Organism:	Mus musculus/domesticus
Length:	1914
Fragment?:	false

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Protein

Q80XK6

Organism:	Mus musculus/domesticus
Length:	2075
Fragment?:	false

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Publication

23122227 | J:212528

First Author:	Rivera A
Year:	2013
Journal:	Blood Cells Mol Dis
Title:	Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis.
Volume:	50
Issue:	2
Pages:	80-5

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Publication

8921395 | J:34210

First Author:	Uwechue IC
Year:	1996
Journal:	Genomics
Title:	The mouse X-linked developmental mutant, tattered, lies between DXMit55 and Xkh and is associated with hyperkeratinization.
Volume:	37
Issue:	2
Pages:	238-41

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Publication

8530041 | J:26635

First Author:	Blair HJ
Year:	1995
Journal:	Genomics
Title:	High-resolution comparative mapping of the proximal region of the mouse X chromosome.
Volume:	28
Issue:	2
Pages:	305-10

•

Publication

34360789 | J:310414

First Author:	Hung CH
Year:	2021
Journal:	Int J Mol Sci
Title:	A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.
Volume:	22
Issue:	15

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Publication

10857745 | J:62168

First Author:	Means GD
Year:	2000
Journal:	Genomics
Title:	A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation.
Volume:	65
Issue:	3
Pages:	213-23

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Publication

10920247 | J:63696

First Author:	Blair HJ
Year:	2000
Journal:	Mamm Genome
Title:	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.
Volume:	11
Issue:	8
Pages:	710-2

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

- | J:157064

First Author:	University of California, Davis
Year:	2010
Journal:	MGI Direct Data Submission
Title:	Alleles produced for the KOMP project by the University of California, Davis

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Publication

- | J:68100

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2001

Title:	RIKEN Data Curation in Mouse Genome Informatics

•

Publication

24194600 | J:228563

First Author:	Koscielny G
Year:	2014
Journal:	Nucleic Acids Res
Title:	The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume:	42
Issue:	Database issue
Pages:	D802-9

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