This entry includes Vps55 from budding yeasts and obesity receptor gene-related protein (OB-RGRP or LEPROT) from animals. Both Vps55 and OB-RGRP are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells [].Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase []. The leptin receptor overlapping transcript (LEPROT) is co-transcribed with Leptin receptor (LepR) but without similarity to the LepR. Mammals have a single LEPROT homologue called LEPROT like-1 (LEPROTL1), which is also included in this entry. LepROT plays roles in insulin pathway []. LEPROT and LEPROTL1 have also been shown to influence liver growth hormone signaling in mice [].
