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Search results 401 to 487 out of 487 for Sost

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Type Details Score
Publication
30664862 | J:278303
First Author: Javaheri B
Year: 2019
Journal: Am J Pathol
Title: Sost Haploinsufficiency Provokes Peracute Lethal Cardiac Tamponade without Rescuing the Osteopenia in a Mouse Model of Excess Glucocorticoids.
Volume: 189
Issue: 4
Pages: 753-761
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Regulatory Region
MGI:5441844 | Rr20
Type: enhancer
Organism: mouse, laboratory
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Allele
Sost<em2(cre/ERT2)Smoc> | MGI:7292534
Name: sclerostin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Allele
Sost<tm1Paz> | MGI:3850014
Name: sclerostin; targeted mutation 1, Chris Paszty
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Tg(RP11-209M4)AGglo/?
Background: FVB-Tg(RP11-209M4)4Gglo
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(RP11-209M4)AGglo/Tg(RP11-209M4)AGglo
Background: FVB-Tg(RP11-209M4)4Gglo
Zygosity: hm
Has Mutant Allele: true
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Allele
Sost<em5Smoc> | MGI:7292537
Name: sclerostin; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Sost/Sost
Background: involves: 129/Sv * Black Swiss
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060756 | sclerosteosis 1
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DO Term
DOID:0080807 | autosomal dominant craniodiaphyseal dysplasia
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Strain
MGI:6429589 | C57BL/6J-Sost<em5Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Sost<tm1(KOMP)Vlcg> | MGI:3797839
Name: sclerostin; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Rr20<tm1.1Vlcg> | MGI:5441845
Name: regulatory region 20; targeted mutation 1.1, Velocigene
Allele Type: Targeted
Attribute String: Modified regulatory region, Null/knockout
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Allele
Sost<tm1.1Ozg> | MGI:7430798
Name: sclerostin; targeted mutation 1.1, Ozgene
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Sost<em4(SOST)Smoc> | MGI:7292536
Name: sclerostin; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Dmp1-SOST)1Btm | MGI:7444919
Name: transgene insertion 1, Teresita Bellido
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Sost<em3(SOST)Smoc> | MGI:7292535
Name: sclerostin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Sost<em1Smoc> | MGI:7292533
Name: sclerostin; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Transgene
MGI:5304470 | Tg(RP11-209M4)AGglo
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Sost/Sost
Background: involves: C57BL/6NTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr20/Rr20
Background: involves: 129S6/SvEvTac * C57BL/6NTac
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0080036 | SOST-related sclerosing bone dysplasia
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HT Experiment
GSE220601 | Effect of Sclerostin Inactivation in a Mouse Model of Severe Dominant Osteogenesis Imperfecta
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Sost<tm1Yako> | MGI:7263279
Name: sclerostin; targeted mutation 1, Yasuhiro Kobayashi
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:6348203 | C57BL/6-Tg(Dmp1-SOST)1Btm/Mmnc
Attribute String: transgenic, coisogenic, mutant strain
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Allele
Tg(Dmp1-SOST)#Alegr | MGI:7512802
Name: transgene insertion, Alexander G Robling
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
31585407 | J:305286
 
First Author: Bullock WA
Year: 2019
Journal: iScience
Title: Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo.
Volume: 20
Pages: 205-215
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Strain
MGI:6476351 | C57BL/6J-Sost<em1(SOST)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
21140374 | J:184242
First Author: Rhee Y
Year: 2011
Journal: J Bone Miner Res
Title: PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling.
Volume: 26
Issue: 5
Pages: 1035-46
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Publication
28607813 | J:283085
 
First Author: He G
Year: 2017
Journal: Bone Res
Title: Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth.
Volume: 5
Pages: 17016
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Strain
MGI:7356356 | B6.FVB-Tg(RP11-209M4)AGglo/J
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5304679 | FVB-Tg(RP11-209M4)4Gglo
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(RP11-209M4*)#Gglo | MGI:5304447
Name: transgene insertion, Gabriela G Loots
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(RP11-209M4)AGglo/?
Background: involves: C57BL/6 * FVB
Zygosity: ot
Has Mutant Allele: true
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Publication
27704638 | J:284501
First Author: Delgado-Calle J
Year: 2017
Journal: J Bone Miner Res
Title: Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor.
Volume: 32
Issue: 3
Pages: 522-535
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Publication
15020244 | -
First Author: Yanagita M
Year: 2004
Journal: Biochem Biophys Res Commun
Title: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.
Volume: 316
Issue: 2
Pages: 490-500
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Protein Domain
IPR008835 | Sclerostin/SOSTDC1
Type: Family
Description: This sclerostin family consists of sclerostin and sclerostin domain-containing protein 1. Sclerostin (SOST) is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterised by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients []. Sclerostin domain-containing protein 1, also known as USAG1, is a bone morphogenetic protein antagonist [].
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Strain
MGI:5304680 | FVB-Tg(RP11-209M4*)#Gglo
Attribute String: transgenic, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Tg(RP11-209M4*)#Gglo/?
Background: FVB-Tg(RP11-209M4*)#Gglo
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(RP11-209M4*)#Gglo/Tg(RP11-209M4*)#Gglo
Background: FVB-Tg(RP11-209M4*)#Gglo
Zygosity: hm
Has Mutant Allele: true
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Publication
24726648 | J:219462
First Author: Kaneko K
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Integrin αv in the mechanical response of osteoblast lineage cells.
Volume: 447
Issue: 2
Pages: 352-7
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Publication
32612176 | J:292165
First Author: Sato T
Year: 2020
Journal: Nat Commun
Title: A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.
Volume: 11
Issue: 1
Pages: 3282
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Publication
34031510 | J:316954
First Author: Song D
Year: 2021
Journal: Sci Rep
Title: Functional interaction between Wnt and Bmp signaling in periosteal bone growth.
Volume: 11
Issue: 1
Pages: 10782
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Publication
29080811 | J:257353
 
First Author: Sebastian A
Year: 2018
Journal: Metabolism
Title: Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models.
Volume: 80
Pages: 38-47
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Publication
35760800 | J:326770
First Author: Liu H
Year: 2022
Journal: Nat Commun
Title: Osteocyte CIITA aggravates osteolytic bone lesions in myeloma.
Volume: 13
Issue: 1
Pages: 3684
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Protein
Q9CQN4
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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HT Experiment
E-GEOD-14242 | Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone
Series Id: GSE14242
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
35137455 | J:333994
First Author: Delgado-Calle J
Year: 2022
Journal: FASEB J
Title: The Notch pathway regulates the bone gain induced by PTH anabolic signaling.
Volume: 36
Issue: 3
Pages: e22196
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Publication
26578715 | J:235906
First Author: Canalis E
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Canonical Notch activation in osteocytes causes osteopetrosis.
Volume: 310
Issue: 2
Pages: E171-82
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Publication
24333171 | J:207902
 
First Author: Kondoh S
Year: 2014
Journal: Bone
Title: Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice.
Volume: 60
Pages: 68-77
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Publication
33722775 | J:315963
 
First Author: Baroi S
Year: 2021
Journal: Bone
Title: PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss.
Volume: 147
Pages: 115913
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Publication
28676438 | J:255351
 
First Author: Zanotti S
Year: 2017
Journal: Bone
Title: Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes.
Volume: 103
Pages: 159-167
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Publication
31067083 | J:289208
First Author: Shiraki M
Year: 2019
Journal: FASEB J
Title: Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts.
Volume: 33
Issue: 8
Pages: 8836-8852
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Publication
22970183 | J:191764
First Author: Grimston SK
Year: 2012
Journal: PLoS One
Title: Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice.
Volume: 7
Issue: 9
Pages: e44222
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Publication
37023531 | J:337847
 
First Author: Movérare-Skrtic S
Year: 2023
Journal: EBioMedicine
Title: B4GALNT3 regulates glycosylation of sclerostin and bone mass.
Volume: 91
Pages: 104546
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Publication
25281615 | J:228774
 
First Author: Martineau C
Year: 2014
Journal: Physiol Rep
Title: Scavenger receptor class B, type I (Scarb1) deficiency promotes osteoblastogenesis but stunts terminal osteocyte differentiation.
Volume: 2
Issue: 10
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Publication
23715728 | J:199255
First Author: Lau KH
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity.
Volume: 305
Issue: 2
Pages: E271-81
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Publication
21220409 | J:170229
First Author: Powell WF Jr
Year: 2011
Journal: J Endocrinol
Title: Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses.
Volume: 209
Issue: 1
Pages: 21-32
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Publication
25389287 | J:324439
First Author: Homer-Bouthiette C
Year: 2014
Journal: J Biol Chem
Title: Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis.
Volume: 289
Issue: 52
Pages: 36303-14
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Publication
19884350 | J:156411
First Author: Meury T
Year: 2010
Journal: Mol Cell Biol
Title: Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo.
Volume: 30
Issue: 1
Pages: 43-53
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Publication
34630143 | J:312849
 
First Author: Xu C
Year: 2021
Journal: Front Physiol
Title: TGF-Beta Receptor II Is Critical for Osteogenic Progenitor Cell Proliferation and Differentiation During Postnatal Alveolar Bone Formation.
Volume: 12
Pages: 721775
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Publication
23963454 | J:203958
First Author: Rhee Y
Year: 2013
Journal: J Biol Chem
Title: Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes.
Volume: 288
Issue: 41
Pages: 29809-20
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Publication
28184001 | J:244496
First Author: Maridas DE
Year: 2017
Journal: J Endocrinol
Title: IGFBP-4 regulates adult skeletal growth in a sex-specific manner.
Volume: 233
Issue: 1
Pages: 131-144
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Publication
31894854 | J:305701
 
First Author: Staines KA
Year: 2020
Journal: Biosci Rep
Title: Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity.
Volume: 40
Issue: 1
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Publication
31521827 | J:283319
 
First Author: Morse A
Year: 2020
Journal: Bone
Title: Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading.
Volume: 131
Pages: 115054
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Publication
25864198 | J:233817
First Author: Maeda A
Year: 2015
Journal: J Biol Chem
Title: WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.
Volume: 290
Issue: 22
Pages: 14004-18
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Publication
25445447 | J:218600
 
First Author: Gerbaix M
Year: 2015
Journal: Bone
Title: Periostin expression contributes to cortical bone loss during unloading.
Volume: 71
Pages: 94-100
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Publication
21887703 | J:233289
First Author: Kaneko K
Year: 2011
Journal: J Bone Miner Res
Title: Physiological function of the angiotensin AT1a receptor in bone remodeling.
Volume: 26
Issue: 12
Pages: 2959-66
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Publication
23696565 | J:201186
First Author: Rahman S
Year: 2013
Journal: Endocrinology
Title: Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton.
Volume: 154
Issue: 8
Pages: 2687-701
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Publication
25490389 | J:220402
First Author: You L
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells.
Volume: 456
Issue: 2
Pages: 598-604
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Publication
25487351 | J:233355
First Author: Remoli C
Year: 2015
Journal: J Bone Miner Res
Title: Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse.
Volume: 30
Issue: 6
Pages: 1030-43
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Publication
28973168 | J:253458
First Author: Chan WCW
Year: 2017
Journal: Hum Mol Genet
Title: Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia.
Volume: 26
Issue: 23
Pages: 4572-4587
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Publication
31068415 | J:281016
First Author: Sun N
Year: 2019
Journal: J Biol Chem
Title: Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism.
Volume: 294
Issue: 25
Pages: 9722-9733
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Publication
34002695 | J:307104
   
First Author: Castro-Mollo M
Year: 2021
Journal: Elife
Title: The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry.
Volume: 10
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Publication
29544022 | J:316614
First Author: Nakatani T
Year: 2018
Journal: J Bone Miner Res
Title: The Deletion of Hdac4 in Mouse Osteoblasts Influences Both Catabolic and Anabolic Effects in Bone.
Volume: 33
Issue: 7
Pages: 1362-1375
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Publication
23891909 | J:203696
First Author: Lloyd SA
Year: 2013
Journal: Bone
Title: Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling.
Volume: 57
Issue: 1
Pages: 76-83
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Publication
31341915 | J:290684
 
First Author: Ohori F
Year: 2019
Journal: J Immunol Res
Title: Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement.
Volume: 2019
Pages: 9716758
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Publication
27519969 | J:255173
 
First Author: Lau KW
Year: 2016
Journal: Bone
Title: Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice.
Volume: 92
Pages: 18-28
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Publication
22161640 | J:231135
First Author: Kramer I
Year: 2012
Journal: J Bone Miner Res
Title: Mef2c deletion in osteocytes results in increased bone mass.
Volume: 27
Issue: 2
Pages: 360-73
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Publication
32634285 | J:324140
First Author: Zhao G
Year: 2020
Journal: J Bone Miner Res
Title: CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH.
Volume: 35
Issue: 11
Pages: 2289-2300
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Publication
26393791 | J:243173
First Author: Xiong J
Year: 2015
Journal: PLoS One
Title: Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone.
Volume: 10
Issue: 9
Pages: e0138189
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Publication
24877630 | J:214373
First Author: Ben-awadh AN
Year: 2014
Journal: Endocrinology
Title: Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.
Volume: 155
Issue: 8
Pages: 2797-809
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Publication
23462960 | J:197550
First Author: Collins JN
Year: 2013
Journal: Endocrinology
Title: Lactating Ctcgrp nulls lose twice the normal bone mineral content due to fewer osteoblasts and more osteoclasts, whereas bone mass is fully restored after weaning in association with up-regulation of Wnt signaling and other novel genes.
Volume: 154
Issue: 4
Pages: 1400-13
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Publication
23044044 | J:193781
First Author: Boudin E
Year: 2013
Journal: Bone
Title: Mutations in sFRP1 or sFRP4 are not a common cause of craniotubular hyperostosis.
Volume: 52
Issue: 1
Pages: 292-5
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Publication
38274045 | J:344641
 
First Author: Raju R
Year: 2023
Journal: Front Physiol
Title: Profiles of Wnt pathway gene expression during tooth morphogenesis.
Volume: 14
Pages: 1316635
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Publication
23583750 | J:203577
First Author: Kao RS
Year: 2013
Journal: Bone
Title: Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone.
Volume: 55
Issue: 2
Pages: 277-87
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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