This entry represents the second of two helical domains (HD2) found in the NLRC proteins [], the NOD2 protein []and NACHT, LRR and PYD domains-containing proteins [, ].
FERM and PDZ domain-containing protein 2 (FRMPD2) may play a role in the regulation of tight junction formation []. It interacts with NOD2 (nucleotide-binding oligomerisation domain-2) via leucine-rich repeats, and acts as a membrane-scaffolding complex that provides a spatial control mechanism for NOD2-mediated immune responses [].
This entry represents the CARD domain found in Receptor Interacting Protein 2 (RIP2). RIP2 harbours a C-terminal CARD domain and functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR)-family, NOD1 and NOD2, which recognizes bacterial peptidoglycans released upon infection. This cascade is implicated in inflammatory immune responses and the clearance of intracellular pathogens. RIP2 associates with NOD1 and NOD2 via CARD-CARDinteractions [].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
