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Search results 401 to 500 out of 560 for Npc1

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Type Details Score
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
21683156 | J:177621
First Author: Tang W
Year: 2011
Journal: Biochim Biophys Acta
Title: Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver.
Volume: 1811
Issue: 9
Pages: 549-55
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HT Experiment
GSE75775 | Neuron-specific changes in gene expression caused by NPC1 deficiency
Series Id: E-GEOD-75775
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Gene
432367 | Npc1l1
Type: gene
Organism: rat
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Gene
463381 | NPC1L1
Type: gene
Organism: chimpanzee
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Gene
610398 | NPC1L1
Type: gene
Organism: dog, domestic
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Gene
539550 | NPC1L1
Type: gene
Organism: cattle
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Gene
699235 | NPC1L1
Type: gene
Organism: macaque, rhesus
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Publication
14976318 | J:89712
First Author: Altmann SW
Year: 2004
Journal: Science
Title: Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.
Volume: 303
Issue: 5661
Pages: 1201-4
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Publication
15173162 | J:121206
First Author: Davis HR Jr
Year: 2004
Journal: J Biol Chem
Title: Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.
Volume: 279
Issue: 32
Pages: 33586-92
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Publication
15671032 | J:98568
First Author: Davies JP
Year: 2005
Journal: J Biol Chem
Title: Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.
Volume: 280
Issue: 13
Pages: 12710-20
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Publication
25696002 | J:233997
First Author: Takada T
Year: 2015
Journal: Sci Transl Med
Title: NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy.
Volume: 7
Issue: 275
Pages: 275ra23
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Publication
21071508 | J:168503
First Author: Adams MR
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine.
Volume: 300
Issue: 1
Pages: G164-9
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Publication
19141868 | J:149640
First Author: Temel RE
Year: 2009
Journal: J Lipid Res
Title: Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent.
Volume: 50
Issue: 5
Pages: 915-23
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Publication
20699423 | J:165600
First Author: Jia L
Year: 2010
Journal: J Lipid Res
Title: Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis.
Volume: 51
Issue: 11
Pages: 3135-44
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Publication
18718999 | J:142281
First Author: Labonté ED
Year: 2008
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.
Volume: 295
Issue: 4
Pages: G776-83
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Publication
17689140 | J:127076
First Author: Knöpfel M
Year: 2007
Journal: Biochim Biophys Acta
Title: Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.
Volume: 1771
Issue: 9
Pages: 1140-7
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Publication
20601625 | J:165455
First Author: Jia L
Year: 2010
Journal: J Lipid Res
Title: Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1.
Volume: 51
Issue: 10
Pages: 3024-33
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Publication
18187667 | J:159818
First Author: Tang W
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice.
Volume: 28
Issue: 3
Pages: 448-54
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Protein Coding Gene
MGI:2685089 | Npc1l1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31064810 | J:289615
First Author: Yamamoto H
Year: 2019
Journal: Mol Pharmacol
Title: Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice.
Volume: 96
Issue: 1
Pages: 47-55
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Publication
34943976 | J:317738
 
First Author: Jia L
Year: 2021
Journal: Cells
Title: NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice.
Volume: 10
Issue: 12
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Publication
34465831 | J:312902
First Author: Ge H
Year: 2021
Journal: Sci Rep
Title: Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death in mice.
Volume: 11
Issue: 1
Pages: 17449
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Publication
20497909 | J:165464
First Author: KÃ¥gedal K
Year: 2010
Journal: Biochim Biophys Acta
Title: Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease.
Volume: 1801
Issue: 8
Pages: 831-8
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Publication
17442616 | J:127024
First Author: Labonté ED
Year: 2007
Journal: Biochim Biophys Acta
Title: Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.
Volume: 1771
Issue: 9
Pages: 1132-9
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Publication
12719428 | J:127188
First Author: Frolov A
Year: 2003
Journal: J Biol Chem
Title: NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
Volume: 278
Issue: 28
Pages: 25517-25
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Publication
17218600 | J:135062
First Author: Davis HR Jr
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice.
Volume: 27
Issue: 4
Pages: 841-9
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HT Experiment
E-GEOD-33467 | Expression data from liver tissue from Npc1 mouse model
Series Id: GSE33467
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Npc1<tm1Tacf> | MGI:6315233
Name: NPC intracellular cholesterol transporter 1; targeted mutation 1, The Addi and Cassi Fund
Allele Type: Targeted
Attribute String: Humanized sequence
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Genotype
Genotype
Symbol: Npc1/Npc1
Background: B6(Cg)-Npc1
Zygosity: hm
Has Mutant Allele: true
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Publication
27551080 | J:235586
First Author: Li X
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.
Volume: 113
Issue: 36
Pages: 10079-84
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Genotype
Genotype
Symbol: Npc1/Npc1
Background: B6(Cg)-Npc1 Npc1
Zygosity: ht
Has Mutant Allele: true
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Publication
18796403 | J:149007
First Author: Tang W
Year: 2009
Journal: J Lipid Res
Title: Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8.
Volume: 50
Issue: 2
Pages: 293-300
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Publication
24336247 | J:226578
First Author: Li PS
Year: 2014
Journal: Nat Med
Title: The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.
Volume: 20
Issue: 1
Pages: 80-6
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Allele
Npc1l1<+> | MGI:3049111
   
Name: NPC1 like intracellular cholesterol transporter 1; wild type
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Publication
29880681 | J:263730
First Author: Zhang YY
Year: 2018
Journal: Science
Title: A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.
Volume: 360
Issue: 6393
Pages: 1087-1092
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Protein Coding Gene
MGP_CAROLIEiJ_G0016068 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018017 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017990 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017954 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017958 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017771 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2685089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017746 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017856 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017848 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017874 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018450 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017113 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017387 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016823 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016910 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22231557 | J:181208
First Author: Sainz B Jr
Year: 2012
Journal: Nat Med
Title: Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.
Volume: 18
Issue: 2
Pages: 281-5
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Publication
29980051 | J:289237
 
First Author: Parini P
Year: 2018
Journal: Atherosclerosis
Title: Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption.
Volume: 275
Pages: 246-255
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Publication
31432115 | J:289936
First Author: Wang Y
Year: 2019
Journal: Mol Med Rep
Title: Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice.
Volume: 20
Issue: 4
Pages: 3224-3232
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Publication
25881076 | J:317864
 
First Author: He J
Year: 2015
Journal: BMC Cancer
Title: NPC1L1 knockout protects against colitis-associated tumorigenesis in mice.
Volume: 15
Pages: 189
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Allele
Npc1l1<tm1a(EUCOMM)Hmgu> | MGI:4842197
Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Npc1l1<em2Gpt> | MGI:7303153
Name: NPC1 like intracellular cholesterol transporter 1; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Npc1l1<em9Gpt> | MGI:7303154
Name: NPC1 like intracellular cholesterol transporter 1; endonuclease-mediated mutation 9, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Npc1l1<tm1e(EUCOMM)Hmgu> | MGI:4841724
Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Npc1l1<em1Gpt> | MGI:7303152
Name: NPC1 like intracellular cholesterol transporter 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Npc1l1<tm1Stky> | MGI:5792802
Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1, Hiroshi Suzuki
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Npc1l1<tm1Yaio> | MGI:3579462
Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1, Yiannis A Ioannou
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Npc1l1<tm1Swa> | MGI:3043784
Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1, Scott W Altmann
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Npc1<em3Smoc> | MGI:7291364
Name: NPC intracellular cholesterol transporter 1; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Npc1<m1N> | MGI:1857409
 
Name: NPC intracellular cholesterol transporter 1; Niemann Pick type C1 NIH
Allele Type: Spontaneous
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Publication
16414355 | J:104982
First Author: Duval C
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine.
Volume: 340
Issue: 4
Pages: 1259-63
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Publication
28627641 | J:271944
First Author: Lin J
Year: 2017
Journal: Mol Med Rep
Title: Osteopontin deficiency protects mice from cholesterol gallstone formation by reducing expression of intestinal NPC1L1.
Volume: 16
Issue: 2
Pages: 1785-1792
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Publication
21187433 | J:168682
First Author: Ge L
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
Volume: 108
Issue: 2
Pages: 551-6
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Strain
MGI:3716665 | C57BL/6-Npc1l1<tm1Yaio>
Attribute String: targeted mutation, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Npc1l1/Npc1l1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Npc1l1/Npc1l1
Background: C57BL/6-Npc1l1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Npc1l1/Npc1l1
Background: involves: C57BL/6 * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Npc1l1/Npc1l1
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Publication
19563754 | -
First Author: Kwon HJ
Year: 2009
Journal: Cell
Title: Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.
Volume: 137
Issue: 7
Pages: 1213-24
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Publication
15604518 | J:96527
First Author: van der Veen JN
Year: 2005
Journal: J Lipid Res
Title: Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.
Volume: 46
Issue: 3
Pages: 526-34
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Protein Domain
IPR004765 | NPC1-like
Type: Family
Description: This family includes mammalian Niemann-Pick C1 (NPC1) protein and its homologues from plants and yeasts. Human NPC1 is a endosomal/lysosomal membrane protein that facilitates the trafficking of cholesterol and other cargo from lysosomes, and is involved in cholesterol homeostasis. Mutations in the NPC1 gene cause the rare neurodegenerative disease Niemann-Pick Type C (NPC) [].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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