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Search results 401 to 500 out of 591 for Aqp2

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Type Details Score
Publication
First Author: Yamaguchi Y
Year: 2006
Journal: Development
Title: Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.
Volume: 133
Issue: 23
Pages: 4737-48
Publication
First Author: Wang F
Year: 2021
Journal: Epigenetics
Title: Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.
Volume: 16
Issue: 11
Pages: 1235-1250
Publication
First Author: Jeong HW
Year: 2009
Journal: J Clin Invest
Title: Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.
Volume: 119
Issue: 11
Pages: 3290-300
Publication
First Author: Desgrange A
Year: 2017
Journal: Development
Title: HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis.
Volume: 144
Issue: 24
Pages: 4704-4719
Publication
First Author: Yang DH
Year: 2011
Journal: Development
Title: Renal collecting system growth and function depend upon embryonic γ1 laminin expression.
Volume: 138
Issue: 20
Pages: 4535-44
Publication
First Author: Hilliard SA
Year: 2014
Journal: Dev Biol
Title: Mdm2 is required for maintenance of the nephrogenic niche.
Volume: 387
Issue: 1
Pages: 1-14
Publication
First Author: Langner E
Year: 2024
Journal: EMBO Rep
Title: Cep120 is essential for kidney stromal progenitor cell growth and differentiation.
Volume: 25
Issue: 1
Pages: 428-454
Publication
First Author: Nagy II
Year: 2016
Journal: BMC Dev Biol
Title: Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.
Volume: 16
Issue: 1
Pages: 30
Publication
First Author: Whiteman EL
Year: 2014
Journal: Mol Cell Biol
Title: Crumbs3 is essential for proper epithelial development and viability.
Volume: 34
Issue: 1
Pages: 43-56
Publication
First Author: Hossain Z
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.
Volume: 104
Issue: 5
Pages: 1631-6
Publication
First Author: Kobayashi H
Year: 2017
Journal: Kidney Int
Title: Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.
Volume: 92
Issue: 6
Pages: 1370-1383
Publication
First Author: Weiss AC
Year: 2020
Journal: J Pathol
Title: Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney.
Volume: 252
Issue: 3
Pages: 290-303
Publication
First Author: Liang X
Year: 2023
Journal: J Am Soc Nephrol
Title: Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.
Volume: 34
Issue: 4
Pages: 572-589
Publication
First Author: Guan N
Year: 2022
Journal: Kidney Int
Title: Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.
Volume: 102
Issue: 1
Pages: 108-120
Publication  
First Author: Niborski LL
Year: 2021
Journal: Dis Model Mech
Title: Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.
Volume: 14
Issue: 5
Publication
First Author: Ihermann-Hella A
Year: 2018
Journal: Stem Cell Reports
Title: Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation.
Volume: 11
Issue: 4
Pages: 912-928
Publication
First Author: Ide S
Year: 2018
Journal: J Am Soc Nephrol
Title: Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development.
Volume: 29
Issue: 12
Pages: 2795-2808
Publication
First Author: Gerl K
Year: 2017
Journal: Am J Pathol
Title: Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.
Volume: 187
Issue: 7
Pages: 1496-1511
Publication
First Author: Yates LL
Year: 2010
Journal: Hum Mol Genet
Title: The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.
Volume: 19
Issue: 23
Pages: 4663-76
Publication
First Author: Rutledge EA
Year: 2017
Journal: Development
Title: Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Volume: 144
Issue: 17
Pages: 3177-3188
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication
First Author: Nelson RD
Year: 1998
Journal: Am J Physiol
Title: Expression of an AQP2 Cre recombinase transgene in kidney and male reproductive system of transgenic mice.
Volume: 275
Issue: 1 Pt 1
Pages: C216-26
Publication
First Author: Petrillo F
Year: 2021
Journal: J Am Soc Nephrol
Title: Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus.
Volume: 32
Issue: 6
Pages: 1339-1354
GXD Expression  
Probe: MGI:7336858
Assay Type: RNA in situ
Annotation Date: 2023-09-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2813028
Stage: TS28
Assay Id: MGI:7531040
Age: postnatal day 9
Image: 4 cortex (right)
Note: No coexpression with Aqp2 in collecting ducts.
Specimen Label: 4 cortex (right)
Detected: false
Specimen Num: 1
Publication
First Author: Park EJ
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: The role of 70-kDa heat shock protein in dDAVP-induced AQP2 trafficking in kidney collecting duct cells.
Volume: 304
Issue: 7
Pages: F958-71
Interaction Experiment
Description: NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.
Publication
First Author: Amlal H
Year: 2003
Journal: J Physiol
Title: Downregulation of renal AQP2 water channel and NKCC2 in mice lacking the apical Na+-H+ exchanger NHE3.
Volume: 553
Issue: Pt 2
Pages: 511-22
Publication
First Author: Han M
Year: 2021
Journal: Am J Physiol Renal Physiol
Title: Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury.
Volume: 320
Issue: 3
Pages: F308-F321
Publication
First Author: Mamuya FA
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: ILK and cytoskeletal architecture: an important determinant of AQP2 recycling and subsequent entry into the exocytotic pathway.
Volume: 311
Issue: 6
Pages: F1346-F1357
Publication
First Author: Nilsson L
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Disruption of cyclooxygenase-2 prevents downregulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse.
Volume: 302
Issue: 11
Pages: F1430-9
GXD Expression    
Probe: MGI:7528879
Assay Type: Immunohistochemistry
Annotation Date: 2023-09-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2806128
Stage: TS28
Assay Id: MGI:7528889
Age: postnatal adult
Note: Not coexpressed with Aqp2 in the collecting duct.
Specimen Label: 6D/F
Detected: false
Specimen Num: 3
Interaction Experiment
Description: AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70.
Publication
First Author: Centrone M
Year: 2017
Journal: Cell Physiol Biochem
Title: AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70.
Volume: 44
Issue: 2
Pages: 515-531
Interaction Experiment
Description: AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b.
Allele
Name: transgene insertion 3, Donald E Kohan
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: aquaporin 2; targeted mutation 1, Wenzheng Zhang
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Allele
Name: aquaporin 2; targeted mutation 1, Shinichi Uchida
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Publication
First Author: Xiao Z
Year: 2016
Journal: Exp Cell Res
Title: Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice.
Volume: 344
Issue: 2
Pages: 167-75
Publication
First Author: Mendoza LD
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice.
Volume: 317
Issue: 3
Pages: F547-F559
Publication
First Author: Ronzaud C
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Inducible renal principal cell-specific mineralocorticoid receptor gene inactivation in mice.
Volume: 300
Issue: 3
Pages: F756-60
Allele
Name: transgene insertion, Jeppe Praetorius
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion, Jeppe Praetorius
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion 2, Donald E Kohan
Allele Type: Transgenic
Attribute String: Recombinase
Strain
Attribute String: targeted mutation, mutant stock
Allele
Name: transgene insertion 1, Gunther Schutz
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion 4, Gunther Schutz
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Genotype
Symbol: Aqp2/Aqp2<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Publication  
First Author: Iervolino A
Year: 2018
Journal: Front Physiol
Title: Integrin Beta 1 Is Crucial for Urinary Concentrating Ability and Renal Medulla Architecture in Adult Mice.
Volume: 9
Pages: 1273
Publication
First Author: Ramkumar N
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion.
Volume: 315
Issue: 3
Pages: F607-F617
Publication
First Author: Ronzaud C
Year: 2007
Journal: J Am Soc Nephrol
Title: Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor.
Volume: 18
Issue: 6
Pages: 1679-87
Publication
First Author: Huang M
Year: 2019
Journal: J Am Soc Nephrol
Title: Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.
Volume: 30
Issue: 11
Pages: 2073-2090
Genotype
Symbol: Ednrb/Ednrb Tg(AQP2-cre)2Dek/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Okada S
Year: 2008
Journal: FASEB J
Title: Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation.
Volume: 22
Issue: 10
Pages: 3672-84
Protein Domain
Type: Family
Description: The aquaporins (AQPs) are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which transport only water, and the aquaglyceroporins, which transport glycerol, urea, or other small solutes []. AQP1 in pleural mesothelial cells participate in the formation of pleural fluid [], renal AQP2 is involved in levels of solutes []and changes in AQP9 in the hippocampus are related to delayed neuronal death []. Aquaporins contain two tandem repeats, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).Aquaporin-11 (AQP11) and aquaporin-12 belong to a new aquaporin subfamily termed superaquaporins []. AQP11 is found in the endoplasmic reticulum and has been connected to policystic kidney disease through knock-out experiments []. It has also been shown that although the characteristic NPA motif may not be fully conserved in both tandem repeats, the molecule nevertheless preserves its water-transport function [].
Publication
First Author: Yakata K
Year: 2007
Journal: Biochim Biophys Acta
Title: Aquaporin-11 containing a divergent NPA motif has normal water channel activity.
Volume: 1768
Issue: 3
Pages: 688-93
Publication  
First Author: Ishibashi K
Year: 2009
Journal: Handb Exp Pharmacol
Title: New members of mammalian aquaporins: AQP10-AQP12.
Issue: 190
Pages: 251-62
Publication
First Author: Rees S
Year: 2014
Journal: J Am Soc Nephrol
Title: Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.
Volume: 25
Issue: 2
Pages: 232-7
Publication
First Author: Kittikulsuth W
Year: 2014
Journal: Physiol Rep
Title: Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling.
Volume: 2
Issue: 3
Pages: e00277
Publication
First Author: Zhang W
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene.
Volume: 304
Issue: 4
Pages: F367-75
Publication
First Author: Zhou Q
Year: 2012
Journal: PLoS One
Title: Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats.
Volume: 7
Issue: 10
Pages: e47360
Publication  
First Author: Hyndman KA
Year: 2017
Journal: J Am Heart Assoc
Title: Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways.
Volume: 6
Issue: 10
Publication
First Author: Hyndman KA
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct.
Volume: 308
Issue: 3
Pages: F244-51
Publication
First Author: Mamuya FA
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.
Volume: 313
Issue: 4
Pages: F1026-F1037
Publication
First Author: Gao Y
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner.
Volume: 311
Issue: 5
Pages: F1074-F1083
Publication
First Author: Lynch IJ
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1.
Volume: 309
Issue: 12
Pages: F1026-34
Publication
First Author: Bugaj V
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Collecting duct-specific endothelin B receptor knockout increases ENaC activity.
Volume: 302
Issue: 1
Pages: C188-94
Publication
First Author: Ge Y
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention.
Volume: 295
Issue: 6
Pages: F1635-40
Genotype
Symbol: Edn1/Edn1 Tg(AQP2-cre)2Dek/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ednra/Ednra Tg(AQP2-cre)2Dek/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Edn1/Edn1 Tg(AQP2-cre)2Dek/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nr3c2/Nr3c2 Tg(Aqp2-cre/ERT2)4Gsc/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Adcy3/Adcy3 Tg(AQP2-cre)2Dek/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Adcy4/Adcy4 Tg(AQP2-cre)2Dek/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Dot1l/Dot1l Tg(Aqp2-icre)1Gsc/?
Background: involves: C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true