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Search results 201 to 284 out of 284 for Spast

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:3724350
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421010
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH403; Specimen C1095
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691559
Age: postnatal adult
Image: UC Davis_1881076
Specimen Label: UC Davis_1881076
Detected: true
Specimen Num: 59
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GXD Expression
GXD Expression
Probe: MGI:3724350
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421010
Age: embryonic day 14.5
Image: MH403; Specimen C1095
Note: Expression was detected in whisker follicle.
Specimen Label: MH403; Specimen C1095
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691559
Age: postnatal adult
Image: UC Davis_1881082
Specimen Label: UC Davis_1881082
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691559
Age: postnatal adult
Image: UC Davis_1881047
Specimen Label: UC Davis_1881047
Detected: true
Specimen Num: 34
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691559
Age: postnatal adult
Image: UC Davis_1881048
Specimen Label: UC Davis_1881048
Detected: true
Specimen Num: 35
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691559
Age: postnatal adult
Image: UC Davis_1881049
Specimen Label: UC Davis_1881049
Detected: true
Specimen Num: 36
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Publication
15269182 | J:92858
First Author: Errico A
Year: 2004
Journal: Hum Mol Genet
Title: Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon.
Volume: 13
Issue: 18
Pages: 2121-32
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Publication
21545838 | J:177948
First Author: Murmu RP
Year: 2011
Journal: Mol Cell Neurosci
Title: Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia.
Volume: 47
Issue: 3
Pages: 191-202
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Publication
27773584 | J:240490
First Author: Brill MS
Year: 2016
Journal: Neuron
Title: Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.
Volume: 92
Issue: 4
Pages: 845-856
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Publication
24065130 | J:202831
First Author: Zempel H
Year: 2013
Journal: EMBO J
Title: Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.
Volume: 32
Issue: 22
Pages: 2920-37
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Publication
30420556 | J:267916
 
First Author: Magiera MM
Year: 2018
Journal: EMBO J
Title: Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport.
Volume: 37
Issue: 23
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Publication
20530212 | J:162689
First Author: Lacroix B
Year: 2010
Journal: J Cell Biol
Title: Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.
Volume: 189
Issue: 6
Pages: 945-54
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Publication
15457338 | J:93069
First Author: Quwailid MM
Year: 2004
Journal: Mamm Genome
Title: A gene-driven ENU-based approach to generating an allelic series in any gene.
Volume: 15
Issue: 8
Pages: 585-91
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Publication
37890489 | J:343289
First Author: Ho KH
Year: 2023
Journal: Dev Cell
Title: Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.
Volume: 58
Issue: 23
Pages: 2641-2651.e6
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Publication
25535916 | J:311814
First Author: Eom TY
Year: 2014
Journal: Dev Cell
Title: Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.
Volume: 31
Issue: 6
Pages: 677-89
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Gt(ROSA)26Sor<tm1.1(CAG-SPAST*C448Y)Baas> | MGI:6343570
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Peter Baas
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Spast<M1Gri> | MGI:3813522
 
Name: spastin; mutation 1, Andrew J Grierson
Allele Type: Chemically induced (ENU)
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Allele
Spast<tm1.1Jme> | MGI:3698038
Name: spastin; targeted mutation 1.1, Judith Melki
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Spast<tm1.1Evre> | MGI:6393452
Name: spastin; targeted mutation 1.1, Evan Reid
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence
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Genotype
Genotype
Symbol: Spast/Spast
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spast/Spast
Background: B6.C-Spast
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110792 | hereditary spastic paraplegia 4
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: C57BL/6N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spast/Spast
Background: C57BL/6-Spast
Zygosity: hm
Has Mutant Allele: true
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Publication
30520996 | J:273408
First Author: Qiang L
Year: 2019
Journal: Hum Mol Genet
Title: Hereditary spastic paraplegia: gain-of-function mechanisms revealed by new transgenic mouse.
Volume: 28
Issue: 7
Pages: 1136-1152
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Protein
Q9JJ94
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
Q78YP7
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Publication
12640030 | -
First Author: Pfannenschmid F
Year: 2003
Journal: J Cell Sci
Title: Chlamydomonas DIP13 and human NA14: a new class of proteins associated with microtubule structures is involved in cell division.
Volume: 116
Issue: Pt 8
Pages: 1449-62
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Publication
9430706 | -
First Author: Ramos-Morales F
Year: 1998
Journal: J Biol Chem
Title: NA14 is a novel nuclear autoantigen with a coiled-coil domain.
Volume: 273
Issue: 3
Pages: 1634-9
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Publication
19273306 | -
 
First Author: Nozawa K
Year: 2009
Journal: Front Biosci (Landmark Ed)
Title: Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome.
Volume: 14
Pages: 3733-9
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Publication
15940689 | -
First Author: Schoppmeier J
Year: 2005
Journal: Cell Motil Cytoskeleton
Title: GFP as a tool for the analysis of proteins in the flagellar basal apparatus of Chlamydomonas.
Volume: 61
Issue: 4
Pages: 189-200
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Publication
25390646 | -
First Author: Goyal U
Year: 2014
Journal: PLoS One
Title: Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.
Volume: 9
Issue: 11
Pages: e112428
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Publication
18459117 | J:203258
First Author: Aki T
Year: 2008
Journal: J Cell Physiol
Title: TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14.
Volume: 217
Issue: 1
Pages: 194-206
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Publication
34970964 | -
   
First Author: Lawrence EJ
Year: 2021
Journal: Elife
Title: SSNA1 stabilizes dynamic microtubules and detects microtubule damage.
Volume: 10
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Protein Domain
IPR033362 | SSNA1_fam
Type: Family
Description: Sjoegren syndrome nuclear autoantigen 1 (SSNA1/NA14) is a major specific target for autoantibodies in Sjögren's Syndrome, a highly prevalent autoimmune disease [, ]. SSNA1 is a microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST []. SSNA1 can assemble into large fibrils, a structure that is important for its interaction with spastin as well as for microtubule dynamics []. It is also a binding partner for the G-protein coupled receptor TPRA40, which regulates early mouse embryogenesis []. Orthologues of SSNA1 are absent from the common eukaryotic model systems Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster but are encoded by the genomes of the flagellated green alga Chlamydomonas reinhardtii (where it is known as deflagellation-inducible protein of 13kDa, DIP13), trematode worms and protozoan parasites. Chlamydomonas reinhardtii DIP13 is localised to centrioles, flagella and cytoplasmic microtubules. It is involved in cell division and flagellar assembly [, ].
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Publication
30814930 | J:319613
 
First Author: Zhou Y
Year: 2019
Journal: Front Cell Neurosci
Title: Comparative Phosphoproteomic Profiling of Type III Adenylyl Cyclase Knockout and Control, Male, and Female Mice.
Volume: 13
Pages: 34
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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