Proline-rich nuclear receptor coactivator 2 (PNRC2) may serve as a bridge between the mRNA decapping complex and the NMD (nonsense-mediated mRNA decay) machinery. It interacts with and triggers movement of hyperphosphorylated Upf1, an important player in NMD, into P bodies. It also interacts with Dcp1a, which is part of the decapping complex []. Moreover, PNRC2 may play a role in controlling the energy balance between energy storage and energy expenditure [].
Proline-rich nuclear receptor coactivator 1 (PNRC1) and proline-rich nuclear receptor coactivator 2 (PNRC2) represent a new type of nuclear receptor co-regulatory proteins [, ]. PNRC1 may play a role in signal transduction []. PNRC2 may be involved in nonsense-mediated mRNA decay (NMD) [].
