Myosin-XVIIIa (MYO18A) is a unique PDZ domain-containing unconventional myosin conserved from Drosophila to vertebrates. Unlike conventional myosins, it has weak ATP-insensitive actin binding ability and does not act as actively translocating motor [, ]. Golgi protein GOLPH3 binds to MYO18A, and this interaction has been suggested to provide the link between Golgi and F-actin []. MYO18A may also function in the adhesion process that maintains the stable attachment of myofibres to ECM (extracellular matrix) and muscle integrity during early development [].
