Secretory pathway Ca-ATPase 2 (SPCA2), also known as ATP2C2, belongs to the IIA subfamily of P-type ATPases, whose members are Ca2+ ATPases that catalyse the hydrolysis of ATP coupled with the transport of calcium across the membrane [].In mammals, SPCA2 plays a role in lactation []. Its expression is linked to tumorigenesis in mammary tumours []. Mutations in the SPCA2 gene are linked to speech and language disorders [].
