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Search results 101 to 159 out of 159 for Ccr10

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Hits by Pathway

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Type Details Score
Pseudogene
MGI_C57BL6J_3693096 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGI_C57BL6J_1891387 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGI_C57BL6J_5434459 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGI_C57BL6J_1891391 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGI_C57BL6J_3708691 | -
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGP_CBAJ_G0039913 | -
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027961 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Pseudogene
MGP_FVBNJ_G0040076 | -
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Ccr10/Cntnap1<tm1Bhat> | MGI:3822136
Name: C-C motif chemokine receptor 10; targeted mutation 1, Manzoor A Bhat
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ccr10/Cntnap1<tm1Bhat> | MGI:2384080
Name: contactin associated protein-like 1; targeted mutation 1, Manzoor A Bhat
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
11123313 | J:66381
First Author: Nakano H
Year: 2001
Journal: J Immunol
Title: Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.
Volume: 166
Issue: 1
Pages: 361-9
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Publication
12080938 | J:76755
First Author: IUIS/WHO Subcommittee on Chemokine Nomenclature.
Year: 2002
Journal: J Immunol Methods
Title: Chemokine/chemokine receptor nomenclature.
Volume: 262
Issue: 1-2
Pages: 1-3
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Protein Coding Gene
MGI:1346316 | Ccl19
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Ccr10/Cntnap1/Ccr10/Cntnap1
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ccr10/Cntnap1/Ccr10/Cntnap1
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Protein
A0A1L1ST82
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Protein Domain
IPR033037 | Ackr2
Type: Family
Description: Atypical chemokine receptor 2 (ACKR2/D6) [], previously known as CCR9 or CCR10 [], is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [, ]. ACKR2 is highly promiscuous and can bind the majority of (if not all) inflammatory CC-chemokines []. It plays an essential role in the resolution of the inflammatory response [, , ]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signalling pathways downstream of ligand binding []. It has been shown to be involved in regulating vessel density [].
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Genotype
Genotype
Symbol: Cntnap1/Ccr10/Cntnap1
Background: involves: 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cntnap1/Ccr10/Cntnap1
Background: involves: 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Publication
24718324 | J:226214
 
First Author: Masahata K
Year: 2014
Journal: Nat Commun
Title: Generation of colonic IgA-secreting cells in the caecal patch.
Volume: 5
Pages: 3704
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Publication
26523865 | J:260631
First Author: Yang J
Year: 2016
Journal: Nat Immunol
Title: Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation.
Volume: 17
Issue: 1
Pages: 48-56
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Publication
22593615 | J:188966
First Author: Shankar SP
Year: 2012
Journal: J Immunol
Title: RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
Volume: 188
Issue: 12
Pages: 6347-56
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Publication
15381732 | J:93940
First Author: Wilson E
Year: 2004
Journal: J Exp Med
Title: CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate.
Volume: 200
Issue: 6
Pages: 805-9
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Publication
10725697 | -
First Author: Homey B
Year: 2000
Journal: J Immunol
Title: Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).
Volume: 164
Issue: 7
Pages: 3465-70
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Publication
11821900 | -
First Author: Homey B
Year: 2002
Journal: Nat Med
Title: CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.
Volume: 8
Issue: 2
Pages: 157-65
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Publication
14581607 | -
First Author: Murakami T
Year: 2003
Journal: J Exp Med
Title: Immune evasion by murine melanoma mediated through CC chemokine receptor-10.
Volume: 198
Issue: 9
Pages: 1337-47
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Protein Domain
IPR005382 | Chemokine_CCR10
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to playa much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten membersof the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 10 (CCR10), previously known as G protein-coupled receptor 2 (GPR2) []. CCR10 is a receptor for CCL27 [], and CCL28 []. CCR10 is found in melanocytes [], dermal fibroblasts, dermal micro-vascular endothelial cells and has also been detected in T-cells []. It is involved in T cell-mediated skin inflammation, having been shown to recruit regulatory T cells to mucosal layers []. The receptor may also play a role in directing metastasis [].
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Publication
21264313 | J:169462
First Author: Shih DQ
Year: 2011
Journal: PLoS One
Title: Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.
Volume: 6
Issue: 1
Pages: e16090
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Publication
21832166 | J:179255
First Author: Cha HR
Year: 2011
Journal: J Immunol
Title: Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control.
Volume: 187
Issue: 6
Pages: 3044-52
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Publication
29237777 | J:256896
First Author: Matsuo K
Year: 2018
Journal: J Immunol
Title: CCL28-Deficient Mice Have Reduced IgA Antibody-Secreting Cells and an Altered Microbiota in the Colon.
Volume: 200
Issue: 2
Pages: 800-809
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Publication
16735375 | J:112072
First Author: Chen L
Year: 2006
Journal: Int Immunol
Title: CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model.
Volume: 18
Issue: 8
Pages: 1233-42
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Publication
21937703 | J:178888
First Author: Sisirak V
Year: 2011
Journal: Blood
Title: CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues.
Volume: 118
Issue: 19
Pages: 5130-40
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Publication
12538707 | J:241132
First Author: Hieshima K
Year: 2003
Journal: J Immunol
Title: CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity.
Volume: 170
Issue: 3
Pages: 1452-61
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Publication
15356112 | J:92762
First Author: Hieshima K
Year: 2004
Journal: J Immunol
Title: CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells.
Volume: 173
Issue: 6
Pages: 3668-75
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Publication
16670280 | J:131687
First Author: Feng N
Year: 2006
Journal: J Immunol
Title: Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection.
Volume: 176
Issue: 10
Pages: 5749-59
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Publication
26854930 | J:232425
First Author: Jacquelot N
Year: 2016
Journal: J Clin Invest
Title: Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma.
Volume: 126
Issue: 3
Pages: 921-37
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Publication
36713846 | J:343357
 
First Author: Chen Z
Year: 2023
Journal: Front Pharmacol
Title: Neutralization of excessive CCL28 improves wound healing in diabetic mice.
Volume: 14
Pages: 1087924
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Publication
23125030 | -
First Author: Graham GJ
Year: 2013
Journal: J Pathol
Title: Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.
Volume: 229
Issue: 2
Pages: 168-75
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Publication
23633677 | -
First Author: Borroni EM
Year: 2013
Journal: Sci Signal
Title: β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.
Volume: 6
Issue: 273
Pages: ra30.1-11, S1-3
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Publication
19130487 | -
First Author: Graham GJ
Year: 2009
Journal: Eur J Immunol
Title: D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes.
Volume: 39
Issue: 2
Pages: 342-51
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Publication
12594248 | -
First Author: Fra AM
Year: 2003
Journal: J Immunol
Title: Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.
Volume: 170
Issue: 5
Pages: 2279-82
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Publication
15004236 | -
First Author: Weber M
Year: 2004
Journal: Mol Biol Cell
Title: The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines.
Volume: 15
Issue: 5
Pages: 2492-508
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Publication
26097478 | -
 
First Author: Graham GJ
Year: 2015
Journal: Front Immunol
Title: D6/ACKR2.
Volume: 6
Pages: 280
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Publication
23479571 | -
First Author: McKimmie CS
Year: 2013
Journal: Blood
Title: An analysis of the function and expression of D6 on lymphatic endothelial cells.
Volume: 121
Issue: 18
Pages: 3768-77
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Publication
15750596 | J:97607
First Author: Jamieson T
Year: 2005
Journal: Nat Immunol
Title: The chemokine receptor D6 limits the inflammatory response in vivo.
Volume: 6
Issue: 4
Pages: 403-11
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Publication
25271254 | J:216439
First Author: Lee KM
Year: 2014
Journal: EMBO J
Title: The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.
Volume: 33
Issue: 21
Pages: 2564-80
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Protein
Q9JL21
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Protein
Q2V6T2
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
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Protein
O08707
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:109762
     
First Author: Mouse Genome Informatics and VEGA Genome Database Project
Year: 2006
Journal: Database Release
Title: Collaboration to Associate VEGA (Vertebrate Genome Annotation) Mouse Gene Models with MGI Markers
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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