Microsomal glutathione S-transferase 1 (MGST1) acts both as a glutathione transferase activity as well as in the reduction of various hydroperoxides, being important in the protection against oxidative stress []. MGST1 is essential for embryonic development and hematopoiesis in vertebrates []. Prostaglandin E synthase, also known as MGST1-like 1, catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) [, ].This entry also includes putative glutathione S-transferase-like proteins from bacteria.
