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Search results 801 to 900 out of 983 for Braf

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Type Details Score
Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129S1/Sv * C57BL/6 * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: either: (involves: 129S2/SvPas * FVB/N ) or (involves: 129S2/SvPas * BALB/c * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: either: (involves: 129S2/SvPas * FVB/N ) or (involves: 129S2/SvPas * BALB/c * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CMV-cre)1Cgn/?
Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Mx1-cre)1Cgn/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Cd207/Cd207<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Cdkn2a/Cdkn2a
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Trp53/Trp53
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(TPO-cre/ERT2)1139Tyj/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Allele
Tg(tetO-BRAF*V600E)26Jaf | MGI:5524276
Name: transgene insertion 26, James A Fagin
Allele Type: Transgenic
Attribute String: Constitutively active, Epitope tag, Inducible, Inserted expressed sequence
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Genotype
Genotype
Symbol: Braf/Braf<+> Polr2a/Polr2a<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:6792071 | STOCK Braf<tm1Mmcm> Gt(ROSA)26Sor<tm14(CAG-tdTomato)Hze> Tg(Mitf-cre)7114Gsb/Cvrk
Attribute String: mutant stock, targeted mutation, transgenic
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Genotype
Genotype
Symbol: Braf/Braf Tshr/Tshr Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Gnas/Gnas Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR046933 | SAM_KSR1_N_sf
Type: Homologous_superfamily
Description: Pseudokinases kinase suppressor of Ras 1 and 2 (KSR1/2) are scaffolds that bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK). They dimerize with kinase-competent RAFs (ARAF, BRAF and CRAF) to stimulate catalysis allosterically []. This entry represents the N-terminal helical hairpin which, together with the SAM-like domain () constitutes the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1. Additionally, MEK binding to the kinase domain of KSR1 asymmetrically drives BRAF-KSR1 heterodimerization, resulting in the concomitant stimulation of BRAF catalytic activity towards free MEK molecules [].
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Protein Domain
IPR046861 | SAM_KSR1_N
Type: Domain
Description: Pseudokinases kinase suppressor of Ras 1 and 2 (KSR1/2) are scaffolds that bridge RAF isoforms and their substrate, mitogen-activated protein kinase kinase (MEK). They dimerize with kinase-competent RAFs (ARAF, BRAF and CRAF) to stimulate catalysis allosterically []. This entry represents the N-terminal helical hairpin which, together with the SAM-like domain () constitutes the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1. Additionally, MEK binding to the kinase domain of KSR1 asymmetrically drives BRAF-KSR1 heterodimerization, resulting in the concomitant stimulation of BRAF catalytic activity towards free MEK molecules [].
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Strain
MGI:5440170 | B6.Cg-Braf<tm2Cpri> Tg(CMV-cre)1Cgn
Attribute String: targeted mutation, transgenic, congenic, mutant strain
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Genotype
Genotype
Symbol: Braf/Braf Tg(Camk2a-cre)1557Sva/?
Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Tek-cre/ERT2)1Arnd/?
Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: B6.129-Braf
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Nes-cre)1Kln/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Nes-cre)1Kln/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Camk2a-cre/ERT2)2Gsc/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:5447425 | B6.Cg-Braf<tm1Mmcm> Tg(Tyr-cre/ERT2)1Lru Pten<tm1Mro>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:4948437 | B6.Cg-Tg(Tyr-cre/ERT2)13Bos Braf<tm1Mmcm> Pten<tm1Hwu>/BosJ
Attribute String: transgenic, targeted mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Braf/Braf Cdkn2a/Cdkn2a Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten Tg(Tyr-cre/ERT2)1Lru/?
Background: B6.Cg-Braf Tg(Tyr-cre/ERT2)1Lru Pten
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR025561 | KSR_SAM-like_dom
Type: Domain
Description: This SAM-like domain is found in kinase suppressor of Ras proteins, which are location-regulated scaffolding proteins connecting MEK to RAF []. This domain is part of the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1.
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Genotype
Genotype
Symbol: Braf/Braf<+> Trp53/Trp53<+> Tg(TPO-cre/ERT2)1139Tyj/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Trp53/Trp53 Tg(TPO-cre/ERT2)1139Tyj/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Protein
Q68FD9
Organism: Mus musculus/domesticus
Length: 1940  
Fragment?: false
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Protein
A0A2R8VHF1
Organism: Mus musculus/domesticus
Length: 1415  
Fragment?: false
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Protein
A2BI30
Organism: Mus musculus/domesticus
Length: 1677  
Fragment?: true
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Protein
Q8C3K4
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
D3YZ21
Organism: Mus musculus/domesticus
Length: 1414  
Fragment?: false
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Protein
Q8BXF0
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: true
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Protein
A0A2R8VKG2
Organism: Mus musculus/domesticus
Length: 2099  
Fragment?: false
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Protein
D3YTS3
Organism: Mus musculus/domesticus
Length: 1799  
Fragment?: false
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Protein
F6ZGR6
Organism: Mus musculus/domesticus
Length: 1300  
Fragment?: false
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Publication
19937730 | -
First Author: Tatevossian RG
Year: 2010
Journal: J Cell Physiol
Title: MAPK pathway activation and the origins of pediatric low-grade astrocytomas.
Volume: 222
Issue: 3
Pages: 509-14
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Protein Domain
IPR024606 | DUF3827
Type: Family
Description: The function of the proteins in this entry is not currently known, but one of the human proteins () has been implicated in pilocytic astrocytomas [, , ]. In the majority of cases of pilocytic astrocytomas a tandem duplication produces an in-frame fusion of the gene encoding this protein and the BRAF oncogene. The resulting fusion protein has constitutive BRAF kinase activity and is capable of transforming cells.
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Genotype
Genotype
Symbol: Braf/Braf Nkx3-1/Nkx3-1<+> Pten/Pten<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Scn10a/Scn10a<+>
Background: involves: 129 * 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Pten/Pten<+> Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mitf-cre)7114Gsb/?
Background: STOCK Braf Gt(ROSA)26Sor Tg(Mitf-cre)7114Gsb/Cvrk
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CMV-cre)1Cgn/?
Background: B6.Cg-Braf Tg(CMV-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Vil1-cre)997Gum/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(CAG-cre)2Osb/?
Background: involves: C57BL * C57BL/6J * DBA * ICR
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:6711383 | STOCK Braf<tm1Mmcm> Gt(ROSA)26Sor<tm3(CAG-EYFP)Hze> Nkx3-1<tm4(cre/ERT2)Mms> Pten<tm1Hwu>/AbshnJ
Attribute String: mutant stock, targeted mutation
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HT Experiment
E-GEOD-33618 | MAPK Signaling Determines Anxiety in the Juvenile Mouse Brain but Depression-like Behavior in Adults
Series Id: GSE33618
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Genotype
Genotype
Symbol: Braf/Braf<+> Grp/Grp Scn10a/Scn10a<+>
Background: involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Grpr/? Scn10a/Scn10a<+>
Background: involves: 129 * 129P2/OlaHsd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(Nes-cre)1Kln/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Raf1/Raf1 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CAG-cre)2Osb/?
Background: involves: C57BL * C57BL/6J * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Raf1/Raf1 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(GFP/KRAS2/ALPP)1Brn/? Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: C57BL/6 * DBA/2 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Kras/Kras<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(Vil1-cre)997Gum/? Trp53/Trp53
Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CAG-cre)2Osb/?
Background: involves: BALB/c * C57BL * C57BL/6J * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Tg(CAG-cre)2Osb/?
Background: involves: C57BL * C57BL/6J * DBA * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Ezh2/Ezh2<+> Tg(Tyr-cre/ERT2)13Bos/?
Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Publication
22318779 | J:189130
First Author: Rebocho AP
Year: 2011
Journal: Cancer Discov
Title: New insight puts CRAF in sight as a therapeutic target.
Volume: 1
Issue: 2
Pages: 98-9
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Allele
Gt(ROSA)26Sor<tm1(tetO-tdTomato,-BRAF*)Mmok> | MGI:5707503
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Markus Morkel
Allele Type: Targeted
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, Reporter
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Allele
Gt(ROSA)26Sor<tm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm> | MGI:5543802
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, David H Gutmann
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter, Transactivator
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Allele
Tg(TG-BRAF*V600E)3Jaf | MGI:5524235
Name: transgene insertion 3, James A Fagin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein
C4IXV3
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Genotype
Genotype
Symbol: Braf/Braf Meox2/Meox2<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1<+> Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1<+> Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Kras/Kras<+> Tg(Tyr-cre/ERT2)1Lru/?
Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Tyr-cre/ERT2)13Bos/? TgTn(sb-T2/Onc)#Dla/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Kras/Kras<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Polr2a/Polr2a Raf1/Raf1
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Kras/Kras<+> Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf<+> Cdkn2a/Cdkn2a Tg(Vil1-cre)997Gum/?
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Raf1/Raf1 H2az2/H2az2<+>
Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Publication
23893969 | J:204469
First Author: Kaul A
Year: 2013
Journal: Genesis
Title: Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.
Volume: 51
Issue: 10
Pages: 708-16
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Publication
22340588 | J:181465
First Author: Cox AD
Year: 2012
Journal: Cancer Cell
Title: The RAF inhibitor paradox revisited.
Volume: 21
Issue: 2
Pages: 147-9
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Publication
23845435 | J:199225
First Author: Rustgi AK
Year: 2013
Journal: Cancer Cell
Title: BRAF: a driver of the serrated pathway in colon cancer.
Volume: 24
Issue: 1
Pages: 1-2
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