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Search results 401 to 500 out of 576 for Mcc

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0.043s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
GO Term
GO:0032126 | eisosome
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GO Term
GO:0070941 | eisosome assembly
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Allele
Gt(ROSA)26Sor<tm1(MCPyV168)Jdec> | MGI:5576261
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, James A DeCaprio
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, No functional change
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Publication
25596282 | J:219802
First Author: Spurgeon ME
Year: 2015
Journal: Cancer Res
Title: Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice.
Volume: 75
Issue: 6
Pages: 1068-79
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Allele
Gt(ROSA)26Sor<tm1(CAG-MCPySTco)Cvp> | MGI:5911880
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Patrick Moore
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Publication
30877126 | J:274880
 
First Author: Lu H
Year: 2019
Journal: Development
Title: Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals.
Volume: 146
Issue: 6
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Protein
P60007
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
Q9D3A0
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Protein
G5E8M3
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
E9Q0Y1
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
A0A1W2P6Q9
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
A0A140T8L6
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
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Protein
H3BIU1
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
A0A1B0GRU6
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
Q66JW5
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Publication
21926987 | -
First Author: Mansfeld J
Year: 2011
Journal: Nat Cell Biol
Title: APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
Volume: 13
Issue: 10
Pages: 1234-43
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Publication
11726501 | -
First Author: Fraschini R
Year: 2001
Journal: EMBO J
Title: Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores.
Volume: 20
Issue: 23
Pages: 6648-59
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Publication
10436016 | -
First Author: Chen RH
Year: 1999
Journal: Mol Biol Cell
Title: The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.
Volume: 10
Issue: 8
Pages: 2607-18
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Protein Domain
IPR026182 | ANAPC15
Type: Family
Description: Human ANAPC15 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, it plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C; it is not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. It also required for degradation of CDC20 [].
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Protein Domain
IPR027097 | Mad2
Type: Family
Description: Mad2 is a central component of the spindle assembly checkpoint, which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis [, ]. In Saccharomyces cerevisiae, it is a component of the mitotic checkpoint complex (MCC) which consists of MAD2, MAD3, BUB3 and CDC20, and of the MAD2-CDC20 subcomplex, both of which appear to be assembled during mitoisis independently of the kinetochore. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 [, , ].
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Strain
MGI:5911883 | B6J.129P2-Gt(ROSA)26Sor<tm1(CAG-MCPySTco)Cvp>/Mmmh
Attribute String: congenic, mutant strain, targeted mutation
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Publication
26544690 | J:243752
First Author: Shuda M
Year: 2015
Journal: PLoS One
Title: Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model.
Volume: 10
Issue: 11
Pages: e0142329
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Publication
32133718 | J:290564
First Author: Roberson EC
Year: 2020
Journal: Dev Dyn
Title: A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain.
Volume: 249
Issue: 7
Pages: 898-905
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Protein
A0A1D5RLD3
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
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Publication
19555689 | -
First Author: Arnaud C
Year: 2009
Journal: FEBS Lett
Title: MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.
Volume: 583
Issue: 14
Pages: 2326-32
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Publication
18591935 | -
First Author: Fukuyama R
Year: 2008
Journal: Oncogene
Title: Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription.
Volume: 27
Issue: 46
Pages: 6044-55
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Protein Domain
IPR040171 | USBP1-like
Type: Family
Description: This entry includes Harmonin-binding protein USHBP1 also known as MCC2) and colorectal mutant cancer protein known as MCC. MCC has been found to suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells [, ]. It may works as a scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2 []. MCC1 inhibits DNA binding of b-catenin/TCF/LEF transcription factors, and it is involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation [, , ].MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumour suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75 [, ].
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Publication
28846109 | J:252675
First Author: Kwun HJ
Year: 2017
Journal: Oncogene
Title: Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting.
Volume: 36
Issue: 49
Pages: 6784-6792
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Publication
26947080 | J:234561
First Author: Marshall CB
Year: 2016
Journal: Cell Rep
Title: p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network.
Volume: 14
Issue: 10
Pages: 2289-300
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Publication
11181649 | J:67587
First Author: Baumgartner MR
Year: 2001
Journal: J Clin Invest
Title: The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency.
Volume: 107
Issue: 4
Pages: 495-504
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Publication
25598413 | J:219725
 
First Author: Takahashi C
Year: 2015
Journal: Nat Commun
Title: mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes.
Volume: 6
Pages: 6017
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Publication
27573463 | J:242663
First Author: Herawati E
Year: 2016
Journal: J Cell Biol
Title: Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton.
Volume: 214
Issue: 5
Pages: 571-86
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Publication
24424413 | J:207985
 
First Author: Lo WL
Year: 2014
Journal: Elife
Title: T cell immunodominance is dictated by the positively selecting self-peptide.
Volume: 3
Pages: e01457
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Publication
25712475 | J:220709
First Author: Funk MC
Year: 2015
Journal: EMBO J
Title: Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.
Volume: 34
Issue: 8
Pages: 1078-89
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Publication
30560893 | J:268391
First Author: Hancock LA
Year: 2018
Journal: Nat Commun
Title: Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice.
Volume: 9
Issue: 1
Pages: 5363
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Publication
31025935 | J:275103
   
First Author: Nanjundappa R
Year: 2019
Journal: Elife
Title: Regulation of cilia abundance in multiciliated cells.
Volume: 8
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Publication
26933123 | J:231675
First Author: Terré B
Year: 2016
Journal: EMBO J
Title: GEMC1 is a critical regulator of multiciliated cell differentiation.
Volume: 35
Issue: 9
Pages: 942-60
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Publication
26565021 | J:230936
First Author: Goretsky T
Year: 2016
Journal: J Biol Chem
Title: A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer.
Volume: 291
Issue: 8
Pages: 4166-77
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Publication
27257214 | J:232849
First Author: Nemajerova A
Year: 2016
Journal: Genes Dev
Title: TAp73 is a central transcriptional regulator of airway multiciliogenesis.
Volume: 30
Issue: 11
Pages: 1300-12
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Publication
23540693 | J:197248
First Author: Shukla R
Year: 2013
Journal: Cell
Title: Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.
Volume: 153
Issue: 1
Pages: 101-11
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Publication
30405130 | J:269158
First Author: Revinski DR
Year: 2018
Journal: Nat Commun
Title: CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.
Volume: 9
Issue: 1
Pages: 4668
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Publication
28512245 | J:242571
First Author: Verhaegen ME
Year: 2017
Journal: Cancer Res
Title: Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in Mice.
Volume: 77
Issue: 12
Pages: 3151-3157
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Publication
36973273 | J:340981
First Author: Thoudam T
Year: 2023
Journal: Nat Commun
Title: Enhanced Ca(2+)-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease.
Volume: 14
Issue: 1
Pages: 1703
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Publication
37257637 | J:338212
     
First Author: Weber M
Year: 2023
Journal: J Invest Dermatol
Title: Merkel Cell Polyomavirus T Antigen-Mediated Reprogramming in Adult Merkel Cell Progenitors.
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Protein
Q8R370
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
G3UW40
Organism: Mus musculus/domesticus
Length: 828  
Fragment?: false
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Publication
15219944 | -
First Author: Hirai A
Year: 2004
Journal: Cancer Lett
Title: Expression of AIE-75 PDZ-domain protein induces G2/M cell cycle arrest in human colorectal adenocarcinoma SW480 cells.
Volume: 211
Issue: 2
Pages: 209-18
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Publication
8232541 | -
First Author: Li R
Year: 1993
Journal: Nature
Title: The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase.
Volume: 366
Issue: 6450
Pages: 82-4
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Publication
15879521 | -
First Author: Poddar A
Year: 2005
Journal: Eukaryot Cell
Title: Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae.
Volume: 4
Issue: 5
Pages: 867-78
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Publication
35322202 | J:327070
First Author: Li Q
Year: 2022
Journal: Cell Death Differ
Title: Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.
Volume: 29
Issue: 8
Pages: 1596-1610
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Publication
30665704 | J:277289
First Author: Bustamante-Marin XM
Year: 2019
Journal: Am J Hum Genet
Title: Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance.
Volume: 104
Issue: 2
Pages: 229-245
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Publication
30587058 | J:288121
First Author: Ding X
Year: 2019
Journal: J Am Heart Assoc
Title: Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Deficiency in Vascular Smooth Muscle Cells Prevents Arteriovenous Fistula Failure Despite Chronic Kidney Disease.
Volume: 8
Issue: 1
Pages: e011211
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Publication
24291092 | J:252164
First Author: Tachibana-Konwalski K
Year: 2013
Journal: Curr Biol
Title: Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.
Volume: 23
Issue: 24
Pages: 2534-9
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Publication
27472059 | J:249684
First Author: Kaul R
Year: 2016
Journal: PLoS One
Title: The Effect of Altered Loading on Mandibular Condylar Cartilage.
Volume: 11
Issue: 7
Pages: e0160121
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Publication
24200693 | J:207774
First Author: Lam HC
Year: 2013
Journal: J Clin Invest
Title: Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
Volume: 123
Issue: 12
Pages: 5212-30
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Publication
32814712 | J:345125
 
First Author: Vega G
Year: 2020
Journal: JCI Insight
Title: Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.
Volume: 5
Issue: 16
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Publication
27435107 | J:345147
First Author: Livraghi-Butrico A
Year: 2017
Journal: Mucosal Immunol
Title: Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.
Volume: 10
Issue: 2
Pages: 395-407
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Publication
26968767 | J:235488
First Author: Grubb BR
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin.
Volume: 310
Issue: 9
Pages: L860-7
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Publication
35143422 | J:323007
 
First Author: Verhaegen ME
Year: 2022
Journal: J Clin Invest
Title: Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.
Volume: 132
Issue: 7
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Publication
23152617 | J:192454
First Author: Vandael DH
Year: 2012
Journal: J Neurosci
Title: Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells.
Volume: 32
Issue: 46
Pages: 16345-59
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Publication
25083992 | J:215765
First Author: Mizumura K
Year: 2014
Journal: J Clin Invest
Title: Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
Volume: 124
Issue: 9
Pages: 3987-4003
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Publication
8946200 | J:37497
First Author: Luongo C
Year: 1996
Journal: Genes Chromosomes Cancer
Title: Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse.
Volume: 17
Issue: 3
Pages: 194-8
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Publication
37847709 | J:342458
     
First Author: Donoghue LJ
Year: 2023
Journal: Am J Physiol Lung Cell Mol Physiol
Title: BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.
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Publication
33094908 | J:335165
First Author: Fujita H
Year: 2020
Journal: Aging Cell
Title: Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.
Volume: 19
Issue: 11
Pages: e13251
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Publication
28607469 | J:275212
First Author: O' Brien MH
Year: 2017
Journal: Sci Rep
Title: PTH [1-34] induced differentiation and mineralization of mandibular condylar cartilage.
Volume: 7
Issue: 1
Pages: 3226
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Publication
11535616 | J:320291
First Author: Sudakin V
Year: 2001
Journal: J Cell Biol
Title: Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.
Volume: 154
Issue: 5
Pages: 925-36
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Publication
8055644 | J:19777
First Author: Davis LM
Year: 1994
Journal: Carcinogenesis
Title: Loss of heterozygosity in spontaneous and chemically induced tumors of the B6C3F1 mouse.
Volume: 15
Issue: 8
Pages: 1637-45
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Publication
21167473 | J:173589
First Author: Serrano MJ
Year: 2011
Journal: Arch Oral Biol
Title: Cell fate mediators Notch and Twist in mouse mandibular condylar cartilage.
Volume: 56
Issue: 6
Pages: 607-13
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Publication
25313532 | J:220621
First Author: Verhaegen ME
Year: 2015
Journal: J Invest Dermatol
Title: Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice.
Volume: 135
Issue: 5
Pages: 1415-1424
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Publication
27880818 | J:247365
First Author: Berrios C
Year: 2016
Journal: PLoS Pathog
Title: Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.
Volume: 12
Issue: 11
Pages: e1006020
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Publication
29321666 | J:261039
First Author: Sunshine JC
Year: 2018
Journal: Oncogene
Title: Are there multiple cells of origin of Merkel cell carcinoma?
Volume: 37
Issue: 11
Pages: 1409-1416
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Publication
33483524 | J:300454
First Author: Brenner L
Year: 2021
Journal: Sci Rep
Title: Functional disruption of cortical cingulate activity attenuates visceral hypersensitivity and anxiety induced by acute experimental colitis.
Volume: 11
Issue: 1
Pages: 2103
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Publication
33564066 | J:303957
First Author: Guo Z
Year: 2021
Journal: Oncogene
Title: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3.
Volume: 40
Issue: 10
Pages: 1821-1835
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Publication
35560034 | J:325278
First Author: Spurgeon ME
Year: 2022
Journal: PLoS Pathog
Title: Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.
Volume: 18
Issue: 5
Pages: e1010551
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Publication
36672392 | J:332805
 
First Author: Houben R
Year: 2023
Journal: Cancers (Basel)
Title: Merkel Cell Polyomavirus: Infection, Genome, Transcripts and Its Role in Development of Merkel Cell Carcinoma.
Volume: 15
Issue: 2
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Protein Coding Gene
MGI:3648807 | Mcidas
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0018899 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020869 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020683 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3648807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020645 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020768 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020752 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020844 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020780 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021366 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019956 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015970 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019778 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22231168 | J:185089
First Author: Stubbs JL
Year: 2012
Journal: Nat Cell Biol
Title: Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation.
Volume: 14
Issue: 2
Pages: 140-7
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GXD Expression
GXD Expression
     
Probe: MGI:5796336
Assay Type: RT-PCR
Annotation Date: 2016-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274120
Stage: TS20
Assay Id: MGI:5796484
Age: embryonic day 12.5
Specimen Label: CP E12.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5796336
Assay Type: RT-PCR
Annotation Date: 2016-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5796484
Age: embryonic day 14.5
Specimen Label: CP E14.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5796336
Assay Type: RT-PCR
Annotation Date: 2016-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274126
Stage: TS26
Assay Id: MGI:5796484
Age: embryonic day 18.5
Specimen Label: CP E18.5
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5796336
Assay Type: RT-PCR
Annotation Date: 2016-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Stage: TS28
Assay Id: MGI:5796484
Age: postnatal adult
Specimen Label: CP adult
Detected: true
Specimen Num: 4
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•
•
•
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