|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 88 out of 88 for Phlpp2

0.028s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
23035 | PHLPP2
Type: gene
Organism: human
•
•
•
•
•
Gene
533130 | PHLPP2
Type: gene
Organism: cattle
•
•
•
•
•
Gene
415881 | PHLPP2
Type: gene
Organism: chicken
•
•
•
•
•
Gene
100101638 | phlpp2
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
707575 | PHLPP2
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
100145264 | phlpp2
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
498949 | Phlpp2
Type: gene
Organism: rat
•
•
•
•
•
Gene
489724 | PHLPP2
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
454384 | PHLPP2
Type: gene
Organism: chimpanzee
•
•
•
•
•
Protein Coding Gene
MGI:2444928 | Phlpp2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
33758172 | J:304405
First Author: Kim K
Year: 2021
Journal: Nat Commun
Title: Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver.
Volume: 12
Issue: 1
Pages: 1822
•
•
•
•
•
Publication
31715176 | J:292493
 
First Author: Wu J
Year: 2020
Journal: Metabolism
Title: Hepatic exosome-derived miR-130a-3p attenuates glucose intolerance via suppressing PHLPP2 gene in adipocyte.
Volume: 103
Pages: 154006
•
•
•
•
•
Publication
31092557 | J:317985
First Author: Nowak DG
Year: 2019
Journal: J Cell Biol
Title: The PHLPP2 phosphatase is a druggable driver of prostate cancer progression.
Volume: 218
Issue: 6
Pages: 1943-1957
•
•
•
•
•
Publication
34394827 | J:322214
 
First Author: Li DF
Year: 2021
Journal: Oxid Med Cell Longev
Title: Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway.
Volume: 2021
Pages: 5570731
•
•
•
•
•
Publication
28859855 | J:256165
First Author: Kim K
Year: 2017
Journal: Gastroenterology
Title: Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.
Volume: 153
Issue: 6
Pages: 1568-1580.e10
•
•
•
•
•
Publication
32268790 | J:317841
First Author: Huang J
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling.
Volume: 40
Issue: 7
Pages: 1705-1721
•
•
•
•
•
Publication
26187040 | J:231241
First Author: Wen YA
Year: 2015
Journal: Biochim Biophys Acta
Title: Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.
Volume: 1852
Issue: 10 Pt A
Pages: 2013-23
•
•
•
•
•
Publication
27760826 | J:308383
First Author: Xiong X
Year: 2016
Journal: J Biol Chem
Title: Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.
Volume: 291
Issue: 48
Pages: 25167-25178
•
•
•
•
•
Publication
25829425 | J:225619
First Author: Nowak DG
Year: 2015
Journal: Cancer Discov
Title: MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.
Volume: 5
Issue: 6
Pages: 636-51
•
•
•
•
•
Publication
24530606 | J:225239
First Author: Li X
Year: 2014
Journal: Gastroenterology
Title: PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Volume: 146
Issue: 5
Pages: 1301-12.e1-10
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0031550 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0034115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0034094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0034021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0034088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0033799 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_2444928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0034608 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0033126 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0033773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0033928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0033872 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0034018 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0033918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0034627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0032829 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0033242 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0023149 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0032668 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3585234
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585660
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3585234
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585660
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3585234
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585660
Age: postnatal day 0-1
Image: P0/1
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3585234
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585660
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3585234
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585660
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3585234
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585660
Age: postnatal adult
Image: Adult
Specimen Label: Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3585234
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585660
Age: embryonic day 16.0
Specimen Label: Embryo
Detected: true
Specimen Num: 6
•
•
•
•
•
Publication
34348155 | J:324786
First Author: Lupse B
Year: 2021
Journal: Cell Rep
Title: Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Volume: 36
Issue: 5
Pages: 109490
•
•
•
•
•
Publication
27481093 | J:236920
 
First Author: Lai M
Year: 2016
Journal: Nat Commun
Title: Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
Volume: 7
Pages: 12207
•
•
•
•
•
Publication
32067289 | J:304943
First Author: Liu Y
Year: 2020
Journal: FASEB J
Title: GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration.
Volume: 34
Issue: 4
Pages: 4918-4933
•
•
•
•
•
Publication
- | J:72245
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
•
•
•
•
•
Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
29930380 | J:267414
     
First Author: Peng M
Year: 2018
Journal: Oncogene
Title: PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein.
•
•
•
•
•
Publication
32694755 | J:325576
First Author: Liu YY
Year: 2021
Journal: Acta Pharmacol Sin
Title: MicroRNA-302a promotes neointimal formation following carotid artery injury in mice by targeting PHLPP2 thus increasing Akt signaling.
Volume: 42
Issue: 4
Pages: 550-559
•
•
•
•
•
Interaction Experiment
Kim K (2017)
Description: Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.
•
•
•
•
•
HT Experiment
E-GEOD-30987 | Identification of PHLPP1 as a tumor suppressor reveals the role of feedback compensation in PTEN-mutant prostate cancer progression
Series Id: GSE30987
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
21840483 | J:176062
First Author: Chen M
Year: 2011
Journal: Cancer Cell
Title: Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.
Volume: 20
Issue: 2
Pages: 173-86
•
•
•
•
•
Publication
23812097 | J:201798
First Author: Kang SG
Year: 2013
Journal: Nat Immunol
Title: MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation.
Volume: 14
Issue: 8
Pages: 849-57
•
•
•
•
•
Publication
26743335 | J:235815
 
First Author: Kim K
Year: 2016
Journal: Nat Commun
Title: mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.
Volume: 7
Pages: 10255
•
•
•
•
•
Publication
21986499 | J:178312
First Author: Liu J
Year: 2011
Journal: Mol Cell Biol
Title: PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth.
Volume: 31
Issue: 24
Pages: 4917-27
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom