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Search results 701 to 784 out of 784 for Lrp6

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Type Details Score
Protein Domain
IPR019330 | MESD
Type: Family
Description: LRP chaperone MESD (also known as mesoderm development candidate 2) represents a set of highly conserved proteins found from nematodes to humans. It is a chaperone that specifically assists with the folding of β-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). It also acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway and is essential for specification of embryonic polarity and mesoderm induction []. The Drosophila homologue, known as boca, is an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members [].The final C-terminal residues, KEDL, are the endoplasmic reticulum retention sequence as it is an ER protein specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs) []. The N- and C-terminal sequences are predicted to adopt a random coil conformation, with the exception of an isolated predicted helix within the N-terminal region, The central folded domain flanked by natively unstructured regions is the necessary structure for facilitating maturation of LRP6 (Low-Density Lipoprotein Receptor-Related Protein 6 Maturation) [].
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Protein Domain
IPR045907 | RNF43_Znf_RING
Type: Domain
Description: This entry represents the RING-type zinc finger domain of E3 ubiquitin-protein ligase RNF43. Proteins containing this domain are found in vertebrates. RNF43 acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6 [, , ]. RNF43 also interacts with NEDD-4-like ubiquitin-protein ligase-1 (NEDL1) and regulates p53-mediated transcription []. It may also be involved in cell growth control potentially through the interaction with, a chromatin-associated protein interfacing the nuclear envelope []. Mutations of RNF43 have been identified in various tumours, including colorectal cancer (CRC), endometrial cancer, mucinous ovarian tumours, gastric adenocarcinoma, pancreatic ductal adenocarcinoma, liver fluke-associated cholangiocarcinoma, hepatocellular carcinoma, and glioma [, , ]. RNF43 contains an N-terminal signal peptide, a protease-associated (PA) domain, a transmembrane (TM) domain and a C3H2C3-type RING-H2 finger domain followed by a long C-terminal region [].In frogs (Xenopus), ZNRF3 and RNF43 were seen to play a key role in limb specification, constituting a master switch along with RSPO2, which may have implications for regenerative medicine [].
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Publication
21693646 | J:198905
First Author: Carmon KS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Volume: 108
Issue: 28
Pages: 11452-7
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Publication
30374194 | J:268149
First Author: Ureña-Peralta JR
Year: 2018
Journal: Sci Rep
Title: Deep sequencing and miRNA profiles in alcohol-induced neuroinflammation and the TLR4 response in mice cerebral cortex.
Volume: 8
Issue: 1
Pages: 15913
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Publication
26417068 | J:227068
First Author: Landskroner-Eiger S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling.
Volume: 112
Issue: 41
Pages: 12812-7
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Publication
26015543 | J:239365
First Author: Das S
Year: 2015
Journal: Development
Title: Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.
Volume: 142
Issue: 12
Pages: 2147-62
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Publication
29718273 | J:262478
First Author: Meo Burt P
Year: 2018
Journal: Endocrinology
Title: FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2.
Volume: 159
Issue: 6
Pages: 2386-2396
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Publication
25715397 | J:220323
First Author: Carpenter AC
Year: 2015
Journal: Development
Title: Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse.
Volume: 142
Issue: 5
Pages: 972-82
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Publication
18487199 | J:138745
First Author: Cheng SL
Year: 2008
Journal: J Biol Chem
Title: Msx2 exerts bone anabolism via canonical Wnt signaling.
Volume: 283
Issue: 29
Pages: 20505-22
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Publication
23901037 | J:233245
First Author: Chang MK
Year: 2014
Journal: J Bone Miner Res
Title: Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity.
Volume: 29
Issue: 1
Pages: 29-42
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Publication
30842262 | J:278215
First Author: Kim SP
Year: 2019
Journal: J Biol Chem
Title: Lrp4 expression by adipocytes and osteoblasts differentially impacts sclerostin's endocrine effects on body composition and glucose metabolism.
Volume: 294
Issue: 17
Pages: 6899-6911
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Publication
20439124 | J:174163
First Author: Phillips MD
Year: 2011
Journal: Int J Cardiol
Title: Dkk1 and Dkk2 regulate epicardial specification during mouse heart development.
Volume: 150
Issue: 2
Pages: 186-92
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Publication
35418614 | J:334644
First Author: Jimbo K
Year: 2022
Journal: Leukemia
Title: Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation.
Volume: 36
Issue: 6
Pages: 1550-1562
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Publication
30978219 | J:274898
First Author: Dickinson KK
Year: 2019
Journal: PLoS One
Title: Molecular determinants of WNT9b responsiveness in nephron progenitor cells.
Volume: 14
Issue: 4
Pages: e0215139
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Publication
25165135 | J:302102
First Author: Liu L
Year: 2014
Journal: Mol Biol Cell
Title: RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway.
Volume: 25
Issue: 21
Pages: 3308-18
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Publication
27543085 | J:249450
First Author: Cheng R
Year: 2016
Journal: Diabetes
Title: Interaction of PPARα With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis.
Volume: 65
Issue: 12
Pages: 3730-3743
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Publication
23211829 | J:214579
First Author: Hu Y
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Pathogenic role of the Wnt signaling pathway activation in laser-induced choroidal neovascularization.
Volume: 54
Issue: 1
Pages: 141-54
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Publication
21576363 | J:174092
First Author: Park K
Year: 2011
Journal: Mol Cell Biol
Title: Identification of a novel inhibitor of the canonical Wnt pathway.
Volume: 31
Issue: 14
Pages: 3038-51
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Publication
31584963 | J:280039
First Author: Nordberg RC
Year: 2019
Journal: PLoS One
Title: LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure.
Volume: 14
Issue: 10
Pages: e0223245
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Publication
17426148 | J:120936
First Author: Bryja V
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.
Volume: 104
Issue: 16
Pages: 6690-5
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Publication
21969569 | J:177451
First Author: Berendsen AD
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Modulation of canonical Wnt signaling by the extracellular matrix component biglycan.
Volume: 108
Issue: 41
Pages: 17022-7
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Publication
11448771 | J:204648
First Author: Semënov MV
Year: 2001
Journal: Curr Biol
Title: Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
Volume: 11
Issue: 12
Pages: 951-61
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Publication
20723538 | J:165596
First Author: von Marschall Z
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling.
Volume: 400
Issue: 3
Pages: 299-304
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Publication
12121999 | J:172892
First Author: Holmen SL
Year: 2002
Journal: J Biol Chem
Title: A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.
Volume: 277
Issue: 38
Pages: 34727-35
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Publication
16730481 | J:114081
First Author: Li J
Year: 2006
Journal: Bone
Title: Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.
Volume: 39
Issue: 4
Pages: 754-66
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Publication
19881541 | J:157025
First Author: Zhang J
Year: 2010
Journal: Oncogene
Title: Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.
Volume: 29
Issue: 4
Pages: 539-49
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Publication
20668165 | J:182839
First Author: Honda T
Year: 2010
Journal: Mol Biol Cell
Title: PDZRN3 negatively regulates BMP-2-induced osteoblast differentiation through inhibition of Wnt signaling.
Volume: 21
Issue: 18
Pages: 3269-77
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Publication
22826439 | J:189142
First Author: Wei W
Year: 2012
Journal: Mol Cell Biol
Title: The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.
Volume: 32
Issue: 19
Pages: 3903-12
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Publication
23959799 | J:205434
First Author: Fei C
Year: 2013
Journal: Mol Cell Biol
Title: Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling.
Volume: 33
Issue: 20
Pages: 4095-105
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Publication
24277854 | J:205516
First Author: Liu J
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
Volume: 110
Issue: 50
Pages: 20224-9
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Publication
25810528 | J:221339
First Author: Schafer ST
Year: 2015
Journal: J Neurosci
Title: The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis.
Volume: 35
Issue: 12
Pages: 4983-98
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Publication
26711269 | J:236204
First Author: Chin EN
Year: 2015
Journal: Mol Cell Biol
Title: Lrp5 Has a Wnt-Independent Role in Glucose Uptake and Growth for Mammary Epithelial Cells.
Volume: 36
Issue: 6
Pages: 871-85
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Publication
29158412 | J:260555
First Author: Khan SK
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Induced GnasR201H expression from the endogenous Gnas locus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling.
Volume: 115
Issue: 3
Pages: E418-E427
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Publication
29632210 | J:261414
First Author: Gerlach JP
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: TMEM59 potentiates Wnt signaling by promoting signalosome formation.
Volume: 115
Issue: 17
Pages: E3996-E4005
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Publication
29777010 | J:264117
 
First Author: Nayak G
Year: 2018
Journal: Development
Title: Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death.
Volume: 145
Issue: 12
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Publication
29659741 | J:298070
First Author: Lian G
Year: 2019
Journal: Cereb Cortex
Title: Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.
Volume: 29
Issue: 5
Pages: 1938-1952
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Publication
33662399 | J:313266
 
First Author: Stypulkowski E
Year: 2021
Journal: J Biol Chem
Title: Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes.
Volume: 296
Pages: 100488
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Publication
22337886 | J:330501
First Author: Palsgaard J
Year: 2012
Journal: J Biol Chem
Title: Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).
Volume: 287
Issue: 15
Pages: 12016-26
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Publication
35133032 | J:330014
First Author: Bhat N
Year: 2022
Journal: FASEB J
Title: TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk.
Volume: 36
Issue: 3
Pages: e22185
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Publication
22895187 | J:186765
First Author: Koo BK
Year: 2012
Journal: Nature
Title: Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Volume: 488
Issue: 7413
Pages: 665-9
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Publication
18313049 | -
First Author: Sugiura T
Year: 2008
Journal: Exp Cell Res
Title: A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.
Volume: 314
Issue: 7
Pages: 1519-28
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Protein
Q9D7F2
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Publication
31564437 | J:287028
First Author: Moosa S
Year: 2019
Journal: Am J Hum Genet
Title: Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta.
Volume: 105
Issue: 4
Pages: 836-843
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Publication
28467820 | J:252529
First Author: Yan KS
Year: 2017
Journal: Nature
Title: Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
Volume: 545
Issue: 7653
Pages: 238-242
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Publication
17613296 | J:142933
First Author: MacDonald BT
Year: 2007
Journal: Bone
Title: Bone mass is inversely proportional to Dkk1 levels in mice.
Volume: 41
Issue: 3
Pages: 331-9
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Publication
19936252 | J:155399
First Author: Choi HY
Year: 2009
Journal: PLoS One
Title: Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.
Volume: 4
Issue: 11
Pages: e7930
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Protein
Q3U3D7
Organism: Mus musculus/domesticus
Length: 1597  
Fragment?: false
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Protein
O70472
Organism: Mus musculus/domesticus
Length: 1877  
Fragment?: false
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Protein
Q8C771
Organism: Mus musculus/domesticus
Length: 774  
Fragment?: true
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Protein
A0A0B4J1F5
Organism: Mus musculus/domesticus
Length: 1535  
Fragment?: false
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Protein Domain
IPR045903 | ZNRF3_Znf_RING
Type: Domain
Description: This entry represents the RING-type zinc finger domain of E3 ubiquitin-protein ligase ZNRF3 (Zinc/RING finger protein 3), a transmembrane enzyme () homologue of Ring finger protein 43 (RNF43). It is predominantly found in vertebrates.In humans, ZNRF3 acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6 [, , ]. ZNRF3 also functions as a tumour suppressor in the intestinal stem cell zone by restricting the size of the intestinal stem cell zone []. In frogs (Xenopus), ZNRF3 and RNF43 were seen to play a key role in limb specification, constituting a master switch along with RSPO2, which may have implications for regenerative medicine []. Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target.
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Publication
29769720 | J:262420
First Author: Szenker-Ravi E
Year: 2018
Journal: Nature
Title: RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.
Volume: 557
Issue: 7706
Pages: 564-569
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Publication
36092718 | J:329279
 
First Author: Støle TP
Year: 2022
Journal: Front Cell Dev Biol
Title: The female syndecan-4-/- heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels.
Volume: 10
Pages: 908126
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Publication
28143772 | J:316018
First Author: Lai KKY
Year: 2017
Journal: Gastroenterology
Title: Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
Volume: 152
Issue: 6
Pages: 1477-1491
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Publication
26476672 | J:318342
 
First Author: Tuo J
Year: 2015
Journal: J Transl Med
Title: Wnt signaling in age-related macular degeneration: human macular tissue and mouse model.
Volume: 13
Pages: 330
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Publication
23756652 | -
First Author: Wang D
Year: 2013
Journal: Genes Dev
Title: Structural basis for R-spondin recognition by LGR4/5/6 receptors.
Volume: 27
Issue: 12
Pages: 1339-44
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Protein
Q5NCP0
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
A3KMI3
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
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Protein
E9PWJ5
Organism: Mus musculus/domesticus
Length: 743  
Fragment?: false
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Protein
Q99JQ5
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
Q8C4X2
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q8BVP5
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q8BTH8
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
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Protein
Q9Z132
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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Protein
Q5SSZ7
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
B1ASC1
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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Protein
Q6P2B2
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
A0A0U1RP94
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
A0A494BAP2
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
A0A0U1RNW0
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
A0A0U1RPM8
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
A0A0U1RPD7
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
Q99K78
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
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Protein
Q91VN0
Organism: Mus musculus/domesticus
Length: 1614  
Fragment?: false
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Protein
O88572
Organism: Mus musculus/domesticus
Length: 1613  
Fragment?: false
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Protein
Q3UI55
Organism: Mus musculus/domesticus
Length: 1614  
Fragment?: false
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Protein
Q571K3
Organism: Mus musculus/domesticus
Length: 1639  
Fragment?: true
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Protein
A0A0R4J0A9
Organism: Mus musculus/domesticus
Length: 1613  
Fragment?: false
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Publication
12665246 | -
First Author: Matthews JM
Year: 2002
Journal: IUBMB Life
Title: Zinc fingers--folds for many occasions.
Volume: 54
Issue: 6
Pages: 351-5
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Publication
17210253 | -
First Author: Gamsjaeger R
Year: 2007
Journal: Trends Biochem Sci
Title: Sticky fingers: zinc-fingers as protein-recognition motifs.
Volume: 32
Issue: 2
Pages: 63-70
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Publication
15963892 | -
First Author: Hall TM
Year: 2005
Journal: Curr Opin Struct Biol
Title: Multiple modes of RNA recognition by zinc finger proteins.
Volume: 15
Issue: 3
Pages: 367-73
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Publication
15718139 | -
First Author: Brown RS
Year: 2005
Journal: Curr Opin Struct Biol
Title: Zinc finger proteins: getting a grip on RNA.
Volume: 15
Issue: 1
Pages: 94-8
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Publication
10529348 | -
First Author: Klug A
Year: 1999
Journal: J Mol Biol
Title: Zinc finger peptides for the regulation of gene expression.
Volume: 293
Issue: 2
Pages: 215-8
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Publication
11179890 | -
First Author: Laity JH
Year: 2001
Journal: Curr Opin Struct Biol
Title: Zinc finger proteins: new insights into structural and functional diversity.
Volume: 11
Issue: 1
Pages: 39-46
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom