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Search results 201 to 297 out of 297 for Lgi1

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0.045s
Type Details Score
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1770123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_19
Specimen Label: euxassay_008470_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1774323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_19
Specimen Label: euxassay_008470_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1914423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_19
Specimen Label: euxassay_008470_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_20
Specimen Label: euxassay_008470_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1770123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_20
Specimen Label: euxassay_008470_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1774323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_20
Specimen Label: euxassay_008470_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1914423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_20
Specimen Label: euxassay_008470_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_21
Specimen Label: euxassay_008470_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1774323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_21
Specimen Label: euxassay_008470_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1770123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_21
Specimen Label: euxassay_008470_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1914423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_21
Specimen Label: euxassay_008470_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_22
Specimen Label: euxassay_008470_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1770123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_22
Specimen Label: euxassay_008470_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1774323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_22
Specimen Label: euxassay_008470_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1914423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_22
Specimen Label: euxassay_008470_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_22
Specimen Label: euxassay_008470_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_23
Specimen Label: euxassay_008470_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1774323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_23
Specimen Label: euxassay_008470_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1770123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_23
Specimen Label: euxassay_008470_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1914423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_23
Specimen Label: euxassay_008470_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1859023
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4825911
Age: embryonic day 14.5
Image: euxassay_008470_23
Specimen Label: euxassay_008470_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2023-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7428366
Age: embryonic day 14.5
Image: S1
Specimen Label: S1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2023-11-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7549239
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2377175
Assay Type: RNA in situ
Annotation Date: 2023-11-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7549239
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
Publication
First Author: Bermingham JR Jr
Year: 2006
Journal: Nat Neurosci
Title: The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.
Volume: 9
Issue: 1
Pages: 76-84
Publication
First Author: Kole MJ
Year: 2015
Journal: J Neurosci
Title: Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.
Volume: 35
Issue: 32
Pages: 11433-44
Publication
First Author: Quillé ML
Year: 2011
Journal: PLoS One
Title: High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies.
Volume: 6
Issue: 9
Pages: e25181
Publication  
First Author: Garaffo G
Year: 2013
Journal: Front Endocrinol (Lausanne)
Title: Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome.
Volume: 4
Pages: 203
Publication
First Author: Fulp CT
Year: 2008
Journal: Hum Mol Genet
Title: Identification of Arx transcriptional targets in the developing basal forebrain.
Volume: 17
Issue: 23
Pages: 3740-60
Publication
First Author: Smith SE
Year: 2012
Journal: J Neurochem
Title: Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels.
Volume: 120
Issue: 4
Pages: 611-21
Publication
First Author: Gineste C
Year: 2013
Journal: Neuromuscul Disord
Title: In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Volume: 23
Issue: 4
Pages: 357-69
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Fukata Y
Year: 2006
Journal: Science
Title: Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
Volume: 313
Issue: 5794
Pages: 1792-5
Transgene
Type: transgene
Organism: mouse, laboratory
Publication
First Author: Head K
Year: 2007
Journal: Mamm Genome
Title: Defining the expression pattern of the LGI1 gene in BAC transgenic mice.
Volume: 18
Issue: 5
Pages: 328-37
Allele
Name: leucine-rich repeat LGI family, member 1; targeted mutation 2.1, John K Cowell
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Publication
First Author: Gu W
Year: 2002
Journal: FEBS Lett
Title: The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins.
Volume: 519
Issue: 1-3
Pages: 71-6
Publication
First Author: Cowell JK
Year: 2010
Journal: Exp Mol Pathol
Title: Inactivation of LGI1 expression accompanies early stage hyperplasia of prostate epithelium in the TRAMP murine model of prostate cancer.
Volume: 88
Issue: 1
Pages: 77-81
Allele
Name: transgene insertion, Matthew P Anderson
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Tg(Lgi1*)#Mpan/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
Allele
Name: transgene insertion, Masaki Fukata
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
Allele
Name: leucine-rich repeat LGI family, member 1; targeted mutation 1, Masaki Fukata
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: leucine-rich repeat LGI family, member 1; targeted mutation 1.1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Null/knockout
Genotype
Symbol: Lgi1/Lgi1
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Lgi1/Lgi1 Tyr/Tyr
Background: B6.Cg-Tyr Lgi1
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Lgi1/Lgi1
Background: involves: 129S2/SvPas * BALB/c * C57BL/6
Zygosity: hm
Has Mutant Allele: true
DO Term
Allele
Name: transgene insertion, Masaki Fukata
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
Allele
Name: transgene insertion, Roger A Nicoll
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
Allele
Name: transgene insertion, Masaki Fukata
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
Genotype
Symbol: Tg(Lgi1)#Mpan/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Skradski SL
Year: 2001
Journal: Neuron
Title: A novel gene causing a mendelian audiogenic mouse epilepsy.
Volume: 31
Issue: 4
Pages: 537-44
Protein Domain
Type: Repeat
Description: Most of the hereditary idiopathic epilepsies are due to mutation in ionchannels expressed in brain. Recently two non-ion channel genes LGI1 andVGLR1 have emerged as important causes of specific epilepsy syndromes. Theproduct of these two genes share a conserved repeated region of about 44 aminoacid residues, the EAR domain (for epilepsy-associated repeat) [].The predicted secondary structure (four β-strands) and the numbers ofrepeated copies (seven) suggest that the EAR domain belongs to theβ-propeller fold. A common functional feature found in all characteriseddomains of this class is a participation in protein-protein interactions.Since the EAR repeat is found in the ectodomain of VLGR1, it is most probablyinvolved in ligand recognition by the receptor [].Proteins known to contain EAR repeats are listed below:Mammalian LGI1 to LGI4. LGI1 is mutated in autosomal dominant partialepilepsy with auditory features (ADPEAF). The F348C missense mutation islocated in the third EAR repeat (7 copies).Mammalian thrombo-spondin N-terminal domain and EAR repeats containgprotein (TSPEAR) (7 copies).Mammalian very large G protein-coupled receptor 1 (VGLR1) or monogenicaudiogenic seizure-susceptible (MASS1) protein. In mouse, mutations inMASS1 gene are associated with generalized epilepsy and seizures inresponse to loud noises (7 copies) [].
Publication
First Author: Scheel H
Year: 2002
Journal: Hum Mol Genet
Title: A common protein interaction domain links two recently identified epilepsy genes.
Volume: 11
Issue: 15
Pages: 1757-62
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
Publication
First Author: Yamagata A
Year: 2018
Journal: Nat Commun
Title: Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Volume: 9
Issue: 1
Pages: 1546
Protein
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1347  
Fragment?: true
Publication
First Author: Marafi D
Year: 2022
Journal: Am J Hum Genet
Title: A reverse genetics and genomics approach to gene paralog function and disease: Myokymia and the juxtaparanode.
Volume: 109
Issue: 9
Pages: 1713-1723
Protein
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 550  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 6298  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 6298  
Fragment?: false