Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
GLI3 is a member of the GLI family of transcription factors, which also includes GLI1 and GLI2. They are central effectors of the Hedgehog (Hh) pathway in vertebrates [, ]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [, , , , ]. |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang B |
Year: |
2000 |
Journal: |
Cell |
Title: |
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. |
Volume: |
100 |
Issue: |
4 |
Pages: |
423-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang C |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. |
Volume: |
305 |
Issue: |
2 |
Pages: |
460-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aoto K |
Year: |
2002 |
Journal: |
Dev Biol |
Title: |
Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. |
Volume: |
251 |
Issue: |
2 |
Pages: |
320-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Persson M |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. |
Volume: |
16 |
Issue: |
22 |
Pages: |
2865-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Humke EW |
Year: |
2010 |
Journal: |
Genes Dev |
Title: |
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. |
Volume: |
24 |
Issue: |
7 |
Pages: |
670-82 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1583
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1583
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1583
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
596
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Anwar S |
Year: |
2015 |
Journal: |
Dev Growth Differ |
Title: |
Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development. |
Volume: |
57 |
Issue: |
8 |
Pages: |
570-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thien H |
Year: |
1996 |
Journal: |
Biochim Biophys Acta |
Title: |
Cloning and sequence analysis of the murine Gli3 cDNA. |
Volume: |
1307 |
Issue: |
3 |
Pages: |
267-9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754322 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is moderate staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus. |
Specimen Label: |
Gli3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754324 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is moderate staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus. |
Specimen Label: |
Gli3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Gli3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753724 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH. |
Specimen Label: |
Gli3 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271822 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Gli3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Gli3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754724 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Gli3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271020 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the premam zone. Staining is either absent or ubiquitous in the ventricular zone of the mam and supramam zones and the TT. |
Specimen Label: |
Gli3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266524 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences. |
Specimen Label: |
Gli3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690619 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 11.5 |
Image: |
Gli3 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus, prethalamus, dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH, the anterior and posterior IDs, the premam, mam and supramam zones and the TT. |
Specimen Label: |
Gli3 - E11.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Gli3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271124 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Gli3 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271220 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Gli3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271224 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Gli3 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691319 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 11.5 |
Image: |
Gli3 - E11.5 |
Note: |
There is very strong staining in the ventricular zone of the cerebral cortex and the ganglionic eminences. |
Specimen Label: |
Gli3 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271824 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones. |
Specimen Label: |
Gli3 - E16.5 |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753922 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is weak staining in the ventricular zone of the dorsal POA. Staining is either absent or ubiquitous in the ventricular zone of the ventral POA, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Gli3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753924 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is moderate staining in the VZ of the ARH nucleus and weak staining in the dorsal and ventral POAs, the PVH nucleus and the AVH. Staining is either absent or ubiquitous in the VZ of the DAH, the SCH, DMH and VMH nuclei and the PH. |
Specimen Label: |
Gli3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271024 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the premam zone. Staining is either absent or ubiquitous in the ventricular zone of the mam and supramam zones. |
Specimen Label: |
Gli3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266520 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences. |
Specimen Label: |
Gli3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266522 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences. |
Specimen Label: |
Gli3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754122 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is strong staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus. |
Specimen Label: |
Gli3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754124 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is strong staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus. |
Specimen Label: |
Gli3 - E16.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Gli3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
Specimen Label: |
Gli3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271222 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
Specimen Label: |
Gli3 - E14.5 |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754320 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is moderate, scattered staining in the ventricular zone of the dorsal thalamus and prethalamus. |
Specimen Label: |
Gli3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Specimen Label: |
Gli3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271820 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT. |
Specimen Label: |
Gli3 - E12.5 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690819 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 11.5 |
Image: |
Gli3 - E11.5 |
Note: |
Staining is strong in the VZ of premam zone & TT, moderate in dorsal thalamus & prethalamus, weak & scattered in dorsal & ventral POAs & PVH nucleus & either absent or ubiquitous in AVH, anterior & posterior IDs, VMH & ARH nuclei & mam & supramam zones. |
Specimen Label: |
Gli3 - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753920 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is moderate, scattered staining in the VZ of the dorsal and ventral POAs and the PVH nucleus and weak staining in the AVH. Staining is either absent or ubiquitous in the VZ of the anterior and posterior IDs and the VMH and ARH nuclei. |
Specimen Label: |
Gli3 - E12.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691119 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 11.5 |
Image: |
Gli3 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences. |
Specimen Label: |
Gli3 - E11.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is very strong staining in the ventricular zone of the cerebral cortex. |
Specimen Label: |
Gli3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271022 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is strong staining in the ventricular zone of the premam zone. Staining is either absent or ubiquitous in the ventricular zone of the mam and supramam zones and the TT. |
Specimen Label: |
Gli3 - E14.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
535
|
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7730799 |
Assay Type: |
Western blot |
Annotation Date: |
2024-09-30 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616417 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7730861 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Gli3 |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7730799 |
Assay Type: |
Western blot |
Annotation Date: |
2024-09-30 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616417 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7730861 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Gli3 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thien H |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene. |
Volume: |
10 |
Issue: |
3 |
Pages: |
205-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hui CC |
Year: |
2011 |
Journal: |
Annu Rev Cell Dev Biol |
Title: |
Gli proteins in development and disease. |
Volume: |
27 |
|
Pages: |
513-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen V |
Year: |
2005 |
Journal: |
Development |
Title: |
Cooperative requirement of the Gli proteins in neurogenesis. |
Volume: |
132 |
Issue: |
14 |
Pages: |
3267-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pohl TM |
Year: |
1990 |
Journal: |
Development |
Title: |
Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt). |
Volume: |
110 |
Issue: |
4 |
Pages: |
1153-7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2684476 |
Assay Type: |
Western blot |
Annotation Date: |
2022-03-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3594417 |
|
Stage: |
TS17 |
Assay Id: |
MGI:7256295 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
Gli3 delta701/delta701 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149477 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6149478 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
Gli3 +/P1-4 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149477 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6149479 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 delta699/delta699 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559166 |
Age: |
embryonic day 10.5 |
Image: |
2 |
|
Specimen Label: |
Gli3 +/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559166 |
Age: |
embryonic day 10.5 |
Image: |
2 |
|
Specimen Label: |
Gli3 delta68/delta68 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149477 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6149478 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
Gli3 P1-4/P1-4 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149477 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6149478 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
Gli3 +/+ |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6149477 |
Assay Type: |
Western blot |
Annotation Date: |
2018-04-05 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6149479 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 delta699/+ |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Renault MA |
Year: |
2009 |
Journal: |
Circ Res |
Title: |
The Hedgehog transcription factor Gli3 modulates angiogenesis. |
Volume: |
105 |
Issue: |
8 |
Pages: |
818-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Genestine M |
Year: |
2007 |
Journal: |
Genesis |
Title: |
High-resolution mapping of the Gli3 deletion in the mouse extra-toesH mutant. |
Volume: |
45 |
Issue: |
3 |
Pages: |
107-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Büscher D |
Year: |
1998 |
Journal: |
Mamm Genome |
Title: |
The XtJ allele generates a Gli3 fusion transcript. |
Volume: |
9 |
Issue: |
8 |
Pages: |
676-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaki PA |
Year: |
2005 |
Journal: |
Eur J Neurosci |
Title: |
Loss of Gli3 enhances the viability of embryonic telencephalic cells in vitro. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1547-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schimmang T |
Year: |
1992 |
Journal: |
Development |
Title: |
Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). |
Volume: |
116 |
Issue: |
3 |
Pages: |
799-804 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hager-Theodorides AL |
Year: |
2005 |
Journal: |
Blood |
Title: |
The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. |
Volume: |
106 |
Issue: |
4 |
Pages: |
1296-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schimmang T |
Year: |
1993 |
Journal: |
Prog Clin Biol Res |
Title: |
Gli3 expression is affected in the morphogenetic mouse mutants add and Xt. |
Volume: |
383A |
|
Pages: |
153-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang S |
Year: |
1997 |
Journal: |
Nat Genet |
Title: |
GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome. |
Volume: |
15 |
Issue: |
3 |
Pages: |
266-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin B |
Year: |
2007 |
Journal: |
ScientificWorldJournal |
Title: |
Involvement of the Gli3 (extra-toes) gene region in body weight in mice. |
Volume: |
7 |
|
Pages: |
83-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ulloa F |
Year: |
2007 |
Journal: |
Curr Biol |
Title: |
Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. |
Volume: |
17 |
Issue: |
6 |
Pages: |
545-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agata A |
Year: |
2023 |
Journal: |
Front Cell Dev Biol |
Title: |
A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice. |
Volume: |
11 |
|
Pages: |
1247361 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vortkamp A |
Year: |
1991 |
Journal: |
Nature |
Title: |
GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. |
Volume: |
352 |
Issue: |
6335 |
Pages: |
539-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naruse I |
Year: |
2010 |
Journal: |
Congenit Anom (Kyoto) |
Title: |
Birth defects caused by mutations in human GLI3 and mouse Gli3 genes. |
Volume: |
50 |
Issue: |
1 |
Pages: |
1-7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1320895 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-01-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1735519 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:1320904 |
Age: |
embryonic day 11.5 |
Image: |
1F |
Note: |
Expression of Gli3 was widespread. |
Specimen Label: |
1F |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1320895 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-01-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1735919 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:1320904 |
Age: |
embryonic day 11.5 |
Image: |
1F |
Note: |
Expression of Gli3 was widespread. |
Specimen Label: |
1F |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559170 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 +/+ P |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559170 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 Xt/+ P |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559170 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 +/+ A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559170 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 delta68/delta68 A |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559170 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 delta68/delta68 P |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559170 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 Xt/+ A |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559170 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 Xt/delta68 A |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5559156 |
Assay Type: |
Western blot |
Annotation Date: |
2014-04-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640517 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5559170 |
Age: |
embryonic day 10.5 |
Image: |
4 |
|
Specimen Label: |
Gli3 Xt/delta68 P |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maynard TM |
Year: |
2002 |
Journal: |
Mamm Genome |
Title: |
High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion. |
Volume: |
13 |
Issue: |
1 |
Pages: |
58-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vortkamp A |
Year: |
1992 |
Journal: |
Mamm Genome |
Title: |
Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt). |
Volume: |
3 |
Issue: |
8 |
Pages: |
461-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ruppert JM |
Year: |
1990 |
Journal: |
Mol Cell Biol |
Title: |
GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. |
Volume: |
10 |
Issue: |
10 |
Pages: |
5408-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Embalabala RJ |
Year: |
2022 |
Journal: |
Cells |
Title: |
GLI3 Is Required for OLIG2+ Progeny Production in Adult Dorsal Neural Stem Cells. |
Volume: |
11 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hager-Theodorides AL |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. |
Volume: |
183 |
Issue: |
5 |
Pages: |
3023-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohba S |
Year: |
2008 |
Journal: |
Dev Cell |
Title: |
Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. |
Volume: |
14 |
Issue: |
5 |
Pages: |
689-99 |
|
•
•
•
•
•
|